Names | |
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Preferred IUPAC name 4-Methyl-1-(propan-2-yl)cyclohex-3-en-1-ol | |
Identifiers | |
3D model (JSmol) | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.008.396 |
MeSH | terpinenol-4 |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C10H18O | |
Molar mass | 154.253 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Terpinen-4-ol is an isomer of terpineol with the chemical formula C10H18O. A primary constituent of tea tree oil, [1] it is obtained as an extract from the leaves, branches, and bark of Melaleuca alternifolia Cheel. [2] [3] [4] Despite considerable basic and preliminary clinical research of terpinen-4-ol and tea tree oil, its biological properties and potential for clinical uses have not been established as of 2019. [2] It may be a factor in the contact dermatitis of tea tree oil when used topically. [2] [3]
Terpinen-4-ol occurs in Juniperus communis and is thought to be the reason why this wood is highly resistant to rot. [ citation needed ]
Terpinen-4-ol can be synthesized from terpinolene (1) by photooxidation, reduction of the resulting hydroperoxide (2), and selective hydrogenation of the terminal double bond in 3.
Dermatitis is inflammation of the skin, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. The area of skin involved can vary from small to covering the entire body. Dermatitis is often called eczema, and the difference between those terms is not standardized.
Melaleuca is a genus of nearly 300 species of plants in the myrtle family, Myrtaceae, commonly known as paperbarks, honey-myrtles or tea-trees. They range in size from small shrubs that rarely grow to more than 16 m (52 ft) high, to trees up to 35 m (115 ft). Their flowers generally occur in groups, forming a "head" or "spike" resembling a brush used for cleaning bottles, containing up to 80 individual flowers.
An essential oil is a concentrated hydrophobic liquid containing volatile chemical compounds from plants. Essential oils are also known as volatile oils, ethereal oils, aetheroleum, or simply as the oil of the plant from which they were extracted, such as oil of clove. An essential oil is essential in the sense that it contains the essence of the plant's fragrance—the characteristic fragrance of the plant from which it is derived. The term "essential" used here does not mean indispensable or usable by the human body, as with the terms essential amino acid or essential fatty acid, which are so called because they are nutritionally required by a living organism.
Lavender oil is an essential oil obtained by distillation from the flower spikes of certain species of lavender. There are over 400 types of lavender worldwide with different scents and qualities. Two forms of lavender oil are distinguished, lavender flower oil, a colorless oil, insoluble in water, having a density of 0.885 g/mL; and lavender spike oil, a distillate from the herb Lavandula latifolia, having a density of 0.905 g/mL. Like all essential oils, it is not a pure compound; it is a complex mixture of phytochemicals, including linalool and linalyl acetate.
Seborrhoeic dermatitis is a long-term skin disorder. Symptoms include flaky, scaly, greasy, and occasionally itchy and inflamed skin. Areas of the skin rich in oil-producing glands are often affected including the scalp, face, and chest. It can result in social or self-esteem problems. In babies, when the scalp is primarily involved, it is called cradle cap. Seborrhoeic dermatitis of the scalp may be described in lay terms as dandruff due to the dry, flaky character of the skin. However, as dandruff may refer to any dryness or scaling of the scalp, not all dandruff is seborrhoeic dermatitis. Seborrhoeic dermatitis is sometimes inaccurately referred to as seborrhoea.
Vitex agnus-castus is a plant native of the Mediterranean region. It is one of the few temperate-zone species of Vitex, which is on the whole a genus of tropical and subtropical flowering plants. Theophrastus mentioned the shrub several times, as agnos (άγνος) in Enquiry into Plants. It has been long believed to be an anaphrodisiac – leading to its name as "chaste tree" – but its effectiveness for such action remains unproven.
Tea tree oil, also known as melaleuca oil, is an essential oil with a fresh, camphoraceous odor and a colour that ranges from pale yellow to nearly colourless and clear. It is derived from the leaves of the tea tree, Melaleuca alternifolia, native to southeast Queensland and the northeast coast of New South Wales, Australia. The oil comprises many constituent chemicals, and its composition changes if it is exposed to air and oxidizes. Commercial use of tea tree oil began in the 1920s, pioneered by the entrepreneur Arthur Penfold. As of 2017 the global tea tree oil market was valued at US$39 million.
Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Symptoms of contact dermatitis can include itchy or dry skin, a red rash, bumps, blisters, or swelling. These rashes are not contagious or life-threatening, but can be very uncomfortable.
Zinc pyrithione is a coordination complex of zinc. It has fungistatic and bacteriostatic properties and is used in the treatment of seborrhoeic dermatitis and dandruff.
An insect repellent is a substance applied to the skin, clothing, or other surfaces to discourage insects from landing or climbing on that surface. Insect repellents help prevent and control the outbreak of insect-borne diseases such as malaria, Lyme disease, dengue fever, bubonic plague, river blindness, and West Nile fever. Pest animals commonly serving as vectors for disease include insects such as flea, fly, and mosquito; and ticks (arachnids).
Cetyl alcohol, also known as hexadecan-1-ol and palmityl alcohol, is a C-16 fatty alcohol with the formula CH3(CH2)15OH. At room temperature, cetyl alcohol takes the form of a waxy white solid or flakes. The name cetyl derives from the whale oil (cetacea oil, from Latin: cetus, lit. 'whale', from Ancient Greek: κῆτος, romanized: kētos, lit. 'huge fish') from which it was first isolated.
Natural skin care uses topical creams and lotions made of ingredients available in nature. Much of the recent literature reviews plant-derived ingredients, which may include herbs, roots, flowers and essential oils, but natural substances in skin care products include animal-derived products such as beeswax, and minerals. These substances may be combined with various carrier agents, preservatives, surfactants, humectants and emulsifiers.
Melaleuca alternifolia, commonly known as tea tree, is a species of tree or tall shrub in the myrtle family, Myrtaceae. Endemic to Australia, it occurs in southeast Queensland and the north coast and adjacent ranges of New South Wales where it grows along streams and on swampy flats, and is often the dominant species where it occurs.
Tetrazepam is a benzodiazepine derivative with anticonvulsant, anxiolytic, muscle relaxant and slightly hypnotic properties. It was formerly used mainly in Austria, France, Belgium, Germany and Spain to treat muscle spasm, anxiety disorders such as panic attacks, or more rarely to treat depression, premenstrual syndrome or agoraphobia. Tetrazepam has relatively little sedative effect at low doses while still producing useful muscle relaxation and anxiety relief. The Co-ordination Group for Mutual Recognition and Decentralised Procedures-Human endorsed the Pharmacovigilance Risk Assessment Committee (PRAC) recommendation to suspend the marketing authorisations of tetrazepam-containing medicines across the European Union (EU) in April 2013. The European Commission has confirmed the suspension of the marketing authorisations for Tetrazepam in Europe because of cutaneous toxicity, effective from the 1 August 2013.
Melaleuca linariifolia is a plant in the myrtle family Myrtaceae, and is endemic to eastern Australia. It is commonly known as snow-in-summer, narrow-leaved paperbark, flax-leaved paperbark and in the language of the Gadigal people as budjur. A hardy plant, it flowers prolifically in late spring or summer, making it a popular garden shrub or small tree in temperate places. Melaleuca trichostachya is a similar species but its leaves are arranged differently and the fruits have projecting valves.
Melaleuca dissitiflora, commonly known as creek tea–tree, is a plant in the myrtle family, Myrtaceae and is native to Australia. It occurs in the drier parts of Queensland, the Northern Territory, South Australia and Western Australia. It grows in places like sandy creek beds and rocky gorges but it may have potential as a more productive source of "tea tree" oil than the usual Melaleuca alternifolia. It is closely related and very similar to Melaleuca linophylla with its papery bark, narrow leaves and loose spikes of creamy-white flowers but its flowers are larger, the stamens are longer and there are more stamens per bundle than in that species.
Aromatherapy is a practice based on the use of aromatic materials, including essential oils and other aroma compounds, with claims for improving psychological well-being. It is offered as a complementary therapy or as a form of alternative medicine. Fragrances used in aromatherapy are not approved as prescription drugs in the United States.
Melaleuca stipitata is a plant in the myrtle family, Myrtaceae and is endemic to a small area in the Northern Territory of Australia. It is a rare species, only discovered in 1991 and is unusual in that it is the only known example of Melaleuca having stalked flowers. Its leaves have an essential oil with a pleasant, lemon scent possibly suitable for commercial production.
Viridiflorol is a chemical compound, classified as a sesquiterpenoid, that has been isolated from the essential oils of a variety of plants including Melaleuca quinquenervia, Melaleuca alternifolia, and Allophylus edulis.
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