Thiazovivin

Last updated
Thiazovivin
Thiazovivin structure.png
Identifiers
  • N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.236.307 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C15H13N5OS
Molar mass 311.36 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
  • InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
  • Key:DOBKQCZBPPCLEG-UHFFFAOYSA-N

Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells, which can then be used for a wide variety of applications. [1] [2] [3] [4]

See also

Related Research Articles

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<span class="mw-page-title-main">Phosphoinositide 3-kinase</span> Class of enzymes

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

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<span class="mw-page-title-main">Low-affinity nerve growth factor receptor</span> Human protein-coding gene

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<span class="mw-page-title-main">Transforming protein RhoA</span> Protein and coding gene in humans

Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 and DIAPH1 are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.

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<span class="mw-page-title-main">SPRED2</span> Protein-coding gene in the species Homo sapiens

Sprouty-related, EVH1 domain-containing protein 2 is a protein that in humans is encoded by the SPRED2 gene.

<span class="mw-page-title-main">Rnd3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Rho-associated protein kinase</span>

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC family of serine-threonine specific protein kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.

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<span class="mw-page-title-main">Rho kinase inhibitor</span>

Rho-kinase inhibitors are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular benefits of statin therapy. Furthermore, ROCK inhibitors may have clinical applications for anti-erectile dysfunction, antihypertension, and tumor metastasis inhibition. More recently they have been studied for the treatment of glaucoma and as a therapeutic target for the treatment of cardiovascular diseases, including ischemic stroke. While statin therapy has been demonstrated to reduce the risk of major cardiovascular events, including ischemic stroke, the interplay between the ROCK pathway and statin therapy to treat and prevent strokes in older adults has not yet been proven.

References

  1. Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, et al. (November 2009). "A chemical platform for improved induction of human iPSCs". Nature Methods. 6 (11): 805–8. doi:10.1038/nmeth.1393. PMC   3724527 . PMID   19838168.
  2. Donai K, Inagaki A, So KH, Kuroda K, Sone H, Kobayashi M, et al. (March 2015). "Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions". Cytotechnology. 67 (2): 191–7. doi:10.1007/s10616-013-9686-8. PMC   4329295 . PMID   24682663.
  3. Mohseni R, Shoae-Hassani A, Verdi J (May 2015). "Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs". Cell Biology International. 39 (5): 515–8. doi:10.1002/cbin.10411. PMID   25490878. S2CID   24813753.
  4. Cheng L, Lei Q, Yin C, Wang HY, Jin K, Xiang M (2017). "Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol". Frontiers in Molecular Neuroscience. 10: 348. doi: 10.3389/fnmol.2017.00348 . PMC   5670152 . PMID   29163026.