Thiazovivin

Thiazovivin

Identifiers
IUPAC name N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
CAS Number	1226056-71-8
PubChem CID	46209426
ChemSpider	24597612
ChEMBL	ChEMBL3184878
CompTox Dashboard (EPA)	DTXSID00673091
ECHA InfoCard	100.236.307
Chemical and physical data
Formula	C15H13N5OS
Molar mass	311.36 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
InChI InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20) Key:DOBKQCZBPPCLEG-UHFFFAOYSA-N

Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells, which can then be used for a wide variety of applications. ^{[1] [2] [3] [4]}

See also

• Rho kinase inhibitor

References

1. Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, et al. (November 2009). "A chemical platform for improved induction of human iPSCs". Nature Methods. 6 (11): 805–8. doi:10.1038/nmeth.1393. PMC   3724527 . PMID   19838168.
2. Donai K, Inagaki A, So KH, Kuroda K, Sone H, Kobayashi M, et al. (March 2015). "Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions". Cytotechnology. 67 (2): 191–7. doi:10.1007/s10616-013-9686-8. PMC   4329295 . PMID   24682663.
3. Mohseni R, Shoae-Hassani A, Verdi J (May 2015). "Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs". Cell Biology International. 39 (5): 515–8. doi:10.1002/cbin.10411. PMID   25490878. S2CID   24813753.
4. Cheng L, Lei Q, Yin C, Wang HY, Jin K, Xiang M (2017). "Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol". Frontiers in Molecular Neuroscience. 10: 348. doi: 10.3389/fnmol.2017.00348 . PMC   5670152 . PMID   29163026.