Thrombospondin-2

Last updated
THBS2
Protein THBS2 PDB 1yo8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases THBS2 , TSP2, thrombospondin 2
External IDs OMIM: 188061 MGI: 98738 HomoloGene: 2438 GeneCards: THBS2
Gene location (Human)
Ideogram human chromosome 6.svg
Chr. Chromosome 6 (human) [1]
Human chromosome 6 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 6q27Start169,215,780 bp [1]
End169,254,044 bp [1]
RNA expression pattern
PBB GE THBS2 203083 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003247

NM_011581

RefSeq (protein)

NP_003238
NP_001368868
NP_001368869
NP_001368870
NP_001368871

Contents

NP_035711

Location (UCSC) Chr 6: 169.22 – 169.25 Mb Chr 17: 14.67 – 14.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. [5] [6]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [6]

Interactions

THBS2 has been shown to interact with MMP2. [7]

Related Research Articles

ADAMTS5

A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene.

Thrombospondin

Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger.

Decorin

Decorin is a protein that in humans is encoded by the DCN gene.

Osteonectin

Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene.

Thrombospondin 1

Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.

MMP2

72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.

ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.

Testicular receptor 4

Testicular receptor 4 also known as NR2C2 is a protein that in humans is encoded by the NR2C2 gene.

Lumican

Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12.

MMP19

Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the MMP19 gene.

MAP2K5

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.

ADAM19

ADAM19 , is a human gene.

Thrombospondin 3

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.

Thrombospondin 4

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.

SPARCL1

SPARC-like protein 1, also known as hevin, is a secreted protein with high structural similarity to SPARC. It interacts with the extracellular matrix to create intermediate states of cell adhesion. Due to its dynamic extracellular roles, being implicated in cancer metastasis and inflammation, it is considered a matricellular protein. In humans hevin is encoded by the SPARCL1 gene.

ADAMTS8

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.

ADAM23

Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene. It is a member of the ADAM family of extracellular matrix metalloproteinases.

ADAMTS3

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene. The protein encoded by this gene is the major procollagen II N-propeptidase.

ADAMTS12

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.

ADAMTS17

ADAM metallopeptidase with thrombospondin type 1 motif, 17 is a protein that in humans is encoded by the ADAMTS17 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186340 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023885 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics. 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC   2427305 . PMID   18455130.
  6. 1 2 "Entrez Gene: THBS2 thrombospondin 2".
  7. Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi: 10.1074/jbc.M003834200 . PMID   10900205.

Further reading