Thumbi Ndung'u

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Thumbi Ndung’u is a Kenyan-born HIV/AIDS researcher. He is the deputy director (Science) and a Max Planck Research Group Leader at the Africa Health Research Institute (AHRI) in Durban, South Africa. He is Professor of Infectious Diseases in the Division of Immunity and Infection, University College London.  He is Professor and Victor Daitz Chair in HIV/TB Research and Scientific Director of the HIV Pathogenesis Programme (HPP) at the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. He holds the South African Research Chair in Systems Biology of HIV/AIDS. He is an Adjunct Professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health. He is the Programme Director of the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE), a research and capacity building initiative funded by the African Academy of Sciences and the Wellcome Trust.

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Ndung’u attended Gathugu Primary School in Kiambu, Kenya and Nyeri High School, Nyeri, Kenya. He graduated with a Bachelor of Veterinary Medicine degree from the University of Nairobi, Kenya, and obtained a PhD in Biological Sciences in Public Health from Harvard University, United States. As a graduate student, he worked with Max Essex at Harvar. He was also a Postdoctoral Fellow in Virology at Harvard Medical School. He is a member of the Academy of Science of South Africa (ASSAf) and a fellow of the African Academy of Sciences (AAS). He has been a member of the External Advisory Board of the HIV Vaccine Trials Network (HVTN), a member of the Scientific Advisory Committee of the Cape Town HVTN Immunology Laboratory (CHIL), a member of the Scientific Advisory Panel of the Poliomyelitis Research Foundation and a member of the advisory board of the Global Health and Vaccination Research Programme (GLOBVAC), The Research Council of Norway. He was co-chair of the Young and Early Career Investigators Committee (YECIC) of the Global HIV Vaccine Enterprise from 2008 to 2010 that worked on the Enterprise's five-year strategic plan.

Ndung’u was the first scientist to clone infectious HIV subtype C and has received numerous awards for his scientific and scholarly contributions. The awards include:

His research interests are host-pathogen interactions, particularly immune mechanisms of HIV and TB control. He has co-authored more than 200 manuscripts in peer-reviewed journals. He has made seminal contributions on our understanding of how virus-host interactions lead to immune-mediated mechanisms of HIV control, which has implications for immune-based prophylactic and therapeutic strategies against the virus. He has received grant funding from the South African National Research Foundation, the South African Medical Research Council, the Bill and Melinda Gates Foundation, the National Institutes of Health, the Howard Hughes Medical Institute, the European Union, the African Academy of Sciences and the Wellcome Trust among others. He is leading a multidisciplinary team of researchers working in the fields of HIV and TB immunopathogenesis, vaccine development and immune-based HIV functional cure strategies. He has special interest in capacity building for biomedical research in Africa.

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<i>Simian immunodeficiency virus</i> Species of retrovirus

Simian immunodeficiency virus (SIV) is a species of retrovirus that cause persistent infections in at least 45 species of African non-human primates. Based on analysis of strains found in four species of monkeys from Bioko Island, which was isolated from the mainland by rising sea levels about 11,000 years ago, it has been concluded that SIV has been present in monkeys and apes for at least 32,000 years, and probably much longer.

<i>Feline immunodeficiency virus</i> Species of virus

Feline immunodeficiency virus (FIV) is a Lentivirus that affects cats worldwide, with 2.5% to 4.4% of felines being infected. FIV differs taxonomically from two other feline retroviruses, feline leukemia virus (FeLV) and feline foamy virus (FFV), and is more closely related to human immunodeficiency virus (HIV). Within FIV, five subtypes have been identified based on nucleotide sequence differences coding for the viral envelope (env) or polymerase (pol). FIV is the only non-primate lentivirus to cause an AIDS-like syndrome, but FIV is not typically fatal for cats, as they can live relatively healthily as carriers and transmitters of the disease for many years. A vaccine is available, although its efficacy remains uncertain. Cats will test positive for FIV antibodies after vaccination.

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CXCR6

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