12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol. It is a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is a small molecule drug.
The China Theatre Plum Blossom Award, more commonly the Plum Blossom Award, is the highest theatrical award in China. It is awarded by the China Theatre Association.
Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium. The structure of phorbol was determined in 1967. Various esters of phorbol have important biological properties, the most notable of which is the capacity to act as tumor promoters through activation of protein kinase C. They mimic diacylglycerols, glycerol derivatives in which two hydroxyl groups have reacted with fatty acids to form esters. The most common and potent phorbol ester is 12-O-tetradecanoylphorbol-13-acetate (TPA), also called phorbol-12-myristate-13-acetate (PMA), which is used as a biomedical research tool in contexts such as models of carcinogenesis.
Phorbol esters are a class of chemical compounds found in a variety of plants, particularly in the families Euphorbiaceae and Thymelaeaceae. Chemically, they are ester derivatives of the tetracyclic diterpenoid phorbol.
C1 domain binds an important secondary messenger diacylglycerol (DAG), as well as the analogous phorbol esters. Phorbol esters can directly stimulate protein kinase C, PKC.
KO One is a 2005 Taiwanese drama starring Jiro Wang, Calvin Chen, Aaron Yan and Danson Tang. It was produced by Comic International Productions and Gala Television, it was first broadcast in Taiwan on cable TV Gala Television (GTV) Variety Show/CH 28 (八大綜合台) on November 26, 2005 to May 27, 2006.
Reaching for the Stars is a 2005 Taiwanese drama broadcast by CTS. This drama casts Taiwanese girl-group S.H.E, Anthony Guo, Chen Zhi Kai, and many others. The soundtrack was released in late 2005, the female leads S.H.E also contributed to the soundtrack. Reaching for the Stars aired its pilot episode during the final episode of The Prince Turned Into A Frog (王子變青蛙) series. The average rating of the pilot episode in Reaching for the Stars was about 1.17, while the final episode of The Prince Turned Into A Frog set a 2005 record for the highest average episode rating (6.93) and the highest episode rating (11.35). Reaching for the Stars only received mediocre television ratings. However, the lead actress Ella was nominated for Best Actress at the 41st Golden Bell Awards in 2006.
Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.
Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.
In enzymology, a phorbol-diester hydrolase (EC 3.1.1.51) is an enzyme that catalyzes the chemical reaction
Chimerin is a type of nerve tissue protein.
Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.
Tigilanol tiglate, sold under the brand name Stelfonta is a medication used to treat dogs with non-metastatic, skin-based (cutaneous) mast cell tumors (MCTs). The FDA is also approving Stelfonta to treat non-metastatic MCTs located under the dog's skin (subcutaneous), in particular areas of a dog's leg. Stelfonta is injected directly into the MCT. Stelfonta works by activating a protein that spreads throughout the treated tumor, which disintegrates tumor cells.
Xiao Yehua is a Chinese former track and field sprinter. Her personal best for the 100 metres was 11.23 seconds, set in 1992. She was a two-time Chinese champion over the 100 m.
Love Cuisine is a 2015 Taiwanese romance, comedy drama television series produced by Sanlih E-Television, starring Lego Lee, Allison Lin, Duncan Chow and Nita Lei as the main cast. Filming began on July 13, 2015 and will be filmed as it airs. First original broadcast began August 7, 2015 on SETTV channel airing every Friday nights at 10:00-11:30 pm.
Queen Dugu is a 2019 Chinese web series starring Joe Chen and Chen Xiao. It is based on the life of Dugu Jialuo and her husband Yang Jian, the founder of the Sui dynasty. It started airing online via iQiyi, Youku and Tencent on February 11, 2019.
Better Days is a 2019 Chinese drama film directed by Derek Tsang and written by Lam Wing Sum, Li Yuan and Xu Yimeng. Based on the Chinese young adult novel In His Youth, In Her Beauty by Jiu Yuexi, the film stars Zhou Dongyu and Jackson Yee, and follows a high school girl struggling with severe bullying and the pressure of upcoming college entrance exams, whose life becomes intertwined with that of a teenage street thug.
The Glory of Youth is the first Chinese Army Rocket Force television series based on Feng Jie's novel Graduated, Being A Soldier developed by The Chinese People's Liberation Army Rocket Force, Starring Li Yifeng, Chen Xingxu, Zhang Xinyu and Xiao Yang. It aired on Zhejiang TV, Jiangsu TV and Youku from 13 April to 11 May 2021. And a special edited version aired on Youku on May 20, 2021
You Are My Glory is a 2021 Chinese television series starring Yang Yang and Dilraba Dilmurat. Based on the novel of the same name written by Gu Man, it mainly tells the story of the popular actress Qiao Jingjing and her former high school classmate Yu Tu unexpectedly reunited in the mobile game Honor of Kings. It premiered on Tencent Video and WeTV on July 26, 2021 until August 30, 2021.
Love Scenery is a 2021 Chinese television series directed by Qin Zhen, adapted from the novel "A bright spear is easy to hide, but a secret love is hard to prevent" (明枪易躲，暗恋难防) by Qiao Yao. It starred Lin Yi and Xu Lu in the leading roles.
