Transient epileptic amnesia

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Transient epileptic amnesia (TEA) is a rare but probably underdiagnosed neurological condition which manifests as relatively brief and generally recurring episodes of amnesia caused by underlying temporal lobe epilepsy. [1] Though descriptions of the condition are based on fewer than 100 cases published in the medical literature, [2] and the largest single study to date included 50 people with TEA, [3] [4] TEA offers considerable theoretical significance as competing theories of human memory attempt to reconcile its implications. [5]

Contents

Symptoms

A person experiencing a TEA episode has very little short-term memory, so that there is profound difficulty remembering events in the past few minutes (anterograde amnesia), or of events in the hours before the onset of the attack, and even memories of important events in recent years may not be accessible during the amnestic event (retrograde amnesia). [6] Some people report short-lived retrograde amnesia so deep that they do not recognize their home or family members, though personal identity is preserved. [7] The amnestic attack has a sudden onset. Three-fourths of cases are reported upon awakening. In attacks that begin when an individual is fully alert, olfactory hallucinations or a "strange taste" [3] or nausea have been reported. Somewhat less than half the cases include olfactory or gustatory hallucinations, and slightly more than a third involve motor automatisms. A quarter of attacks involve a brief period of unresponsiveness. [4] Frequently, however, there is no warning.

During the attack the person's cognitive functions are not generally impaired; perception, communication, attention are normal for most of the duration of the event. [3] In half the cases reported, behavior includes repetitive questioning to attempt to orient experience as the brain fails to lay down new memories or recall a range of recent experiences. [4] The website of the UK-based organization The Impairment of Memory in Epilepsy (TIME) describes an attack this way: [8]

During an attack, the person is usually unable to remember things that have happened over the past days or weeks. Sometimes, the memory loss may affect events from much further back in the past. Also, the individual often finds it difficult to retain new information and may ask the same question, such as "What day is it?" or "What are we supposed to be doing today?" repetitively. There is, however, no loss of personal identity, and close friends or relatives are usually recognised. The physical appearance of the person is normally unchanged. Observers may, however, notice some pallor of the skin, a brief 'loss of contact' such as not seeming to be aware of the person witnessing the attack, or some automatic movements such as swallowing, lip-smacking or fidgeting of the hands. In most cases, however, the person responds appropriately to the situation they are in. They carry on conversations and can continue with activities such as getting dressed, walking, or even playing a game of golf. [8]

Attacks typically last 20 to 60 minutes. Some attacks may be less than five minutes in duration. Much longer attacks have been reported; in the 2007 study of 50 TEA cases, one lasted four days and one lasted two days. [4] Such unusual presentations "may be due to ongoing seizure activity (non-convulsive status epilepticus) or persistent post-ictal dysfunction of memory-related brain structures." [3]

As the amnesia resolves, the person may recall very little about it, although some memory may be retained of the fact of an episode. [3] Of greater consequence than this brief gap are three common persistent memory complaints among people who have experienced TEA: difficulty recalling knowledge recently gained (accelerated forgetting); difficulty recalling events in one's personal life over a period of decades (autobiographical amnesia); and difficulty with spatial memory, recalling routes or places and the navigational cues that are associated with them (topographical amnesia), discussed below.

Diagnosis

Transient amnesia can be the principal manifestation of epilepsy. This diagnosis, however, is "seldom suspected by clinicians and remains controversial". [4] TEA is "almost always misdiagnosed" according to a leading authority. [9] In the largest study to date (2007) "Epilepsy was the initial specialist diagnosis in only 12 of 50 cases." [4] Diagnosis is further complicated by the fact that only somewhat more than a third of cases present positive EEG readings after the attack. [10] However, as TEA tends to recur at a median rate of 12 times a year, [4] witnesses and clinicians may be able to recognize the condition retrospectively; the median delay to diagnosis of TEA in the 2007 study was 12 months. [4]

TEA is a form of focal seizure, which is "the most common variety of adult-onset epilepsy" as opposed to the stereotypical tonic-clonic or grand mal seizure in which affected persons suffer a loss of consciousness and convulse. [11] Diagnostic criteria for the disorder were adopted in the 2007 study of 50 case emphasized clinical features that distinguish TEA from transient global amnesia (TGA), with which TEA is often compared: [4]

Neuroimaging during events

An individual in the midst of a prolonged TEA attack was given a PET scan which revealed "dramatic and circumscribed hypermetabolism in the left medial temporal lobe" and his "fluid-attenuated inversion-recovery MRI scan revealed high signal in the left hippocampus". [13] Surface EEG recording during an amnesic attack was performed in ten TEA cases. "All recordings showed seizure activity, which in 8/10 cases involved both temporal lobes and in the others remained unilateral (1 left and one right-sided)." [2] "Another patient was having an EEG when a TGA event occurred; the trace showed a one-minute burst of left temporal spikes, followed by normalization of the EEG. [4] MRI or CT scans have been reported in 62 TEA cases, with a very low incidence of clinically significant findings. Those focal brain lesions that have been detected have involved the medial temporal lobes. [2] Typically, MRI and CT findings are not remarkable. [6]

Other transient amnestic syndromes

TEA is, at first, a challenge to distinguish its salient features during the event from transient global amnesia and psychogenic amnesia, though other forms of transient amnesia can include reactions to various medications, closed head injury, and migraine. [6] [13] (Other sources of amnestic symptoms include herpes encephalitis, hypoxia, vascular or basal forebrain lesions, deep midline tumors, early dementia, and Korsakoff syndrome which is secondary to thiamine deficiency, most often the result of alcohol use disorder. [1] )

The anatomical and pathophysiological basis of TEA is presumed to be similar to transient global amnesia (TGA), that is, it is likely to be primarily hippocampal in origin, but with more variable involvement of limbic and adjacent temporal lobe neocortical structures. [7]

Typical presentation [7] [13] TEATGA
Age at onsetearly 60searly 60s
Gender67% male46% male
Precipitating factors70%:sleep/waking80%: stress, exercise, cold water
Historyepilepsymigraine
Procedural memoryintactintact
Recognizes family, homeusuallyyes
Duration1–60 minutes2–8 hours
EEGduring: abnormal
after: 40%+abnormal
during: normal
after: 7% develop epilepsy
Other occasional symptomsbrief unresponsivenessnausea, headache
Autonomic actionsYes (40%)no
Degree of amnesia of event44% have partial recallno recall
Personal identityintactintact
Persistent memory loss80%+:
ALF
autobiographical amnesia
topographical amnesia
30%+:
ALF
autobiographical amnesia
.
Hallucination42%: olfactory and gustatoryno
Treatmentanticonvulsant medicationnone
Recurrence12-13/yearrare

Epidemiology

TEA characteristically starts in late middle-age. A sample of validated individuals with TEA had a mean age of 62 and a range of 44 to 77 years of age for the first attack. [4] Research samples have been predominantly male by a ratio of two-to-one. [4] [6] The IQ of people diagnosed with TEA tends to be in the high average to superior range, perhaps due to selection bias. [4] [12]

Persistent memory effects

Memory difficulties are among the most common issues for people with epilepsy, [14] and "persistent memory impairment is reported by about 75% of patients with TEA." [13] Other studies suggest the rate exceeds 80%. [2] People who have had TEA attacks frequently report three kinds of persistent problems with memory:

Importantly, these types of memory difficulty are not detected by standard neuropsychological tests. [2] [3] [5] [15] [16]

Accelerated long-term forgetting (ALF)

Accelerated long-term forgetting (ALF) may be described as the abnormally rapid loss of recently learned material from memory. People who have experienced TEA often have difficulty in recalling information over days to weeks, even if this information was well learned initially. [1] [15] Even though accelerated memory loss is reported in 44% of TEA patients, it is undetected by standard tests of memory. [2] Typically these tests examine the ability to store information for up to 30 minutes but the problem of accelerated long-term forgetting in TEA patients is not generally noticeable at this point. It becomes apparent over the following days and weeks. [13] [16] A recent study indicated that acquisition of recently everyday events can be normal after 30 minutes delay but that within 24 hours patients recall significantly less information than age and IQ matched control participants. [17] Several non-mutually exclusive hypotheses have been advanced to explain why TEA patients experience accelerated forgetting. [2]

Seizures in TEA patients commonly occur upon waking suggesting a link between TEA and sleep. It is possible that abnormal electrical activity during sleep disrupts the process of memory consolidation which normally occurs when we sleep. On-going subclinical seizure activity has implications for theories of memory consolidation, discussed below.

It is possible that a pre-existing condition affecting the temporal lobe may both cause attacks of TEA and interfere with the handling of memories. "Alternatively, episodes of TEA might themselves give rise to structural damage within the hippocampus or related structures, which could disrupt long term consolidation." [16] One study found "subtle hippocampal volume loss" in patients with TEA, but the atrophy did not correspond to measures of either ALF or autobiographical memory loss, suggesting "a more diffuse physiological basis rather than being a consequence of structural damage." [14]

Antiepileptic drugs sometimes affect memory. However, this is unlikely to be the cause of ALF in TEA, as patients tend to report memory problems before they start taking the antiepileptic drugs and can experience improvement in their memory after taking them. [2]

Research has reported that low mood and poor self-esteem are associated with memory problems. These are important factors when investigating patients with epilepsy in general. However, in TEA they do not appear to play an important role in accelerated forgetting. [4] [15]

Remote memory loss

70% [4] of people with TEA notice a patchy but persistent loss of memories of events from their past personal experiences [5] [18] and this autobiographical amnesia has been reported in all cases in which accelerated forgetting was also present. [2] This memory loss can occur in people whose ability to acquire new memories is intact. [2] Studying this 'autobiographical amnesia' [4] or 'focal retrograde amnesia' [19] or 'delayed onset amnesia' [16] has been challenging because people do not always realize they have forgotten events or periods of time until they have difficulty in retrieving memories of specific significant events, and find they cannot form a coherent recollection. At first they might think they have forgotten some isolated events due to normal forgetting, and not realize they have forgotten larger blocks of past time:

In our experience, patients most often present complaining of islands of memory loss that become apparent when discussing holidays or family events. We now ask patients with suspected TEA if they have gaps in their autobiographical memory, and especially about recall of holidays and other salient personal events. This is not, we would argue, because of the unique status of such events, but rather because it reflects the patchy nature of the remote memory deficit and the vulnerability of singular events. It is unlikely that a single week missing from everyday life would be noticed, owing to the repetitive nature of most day to day activities. In contrast, the loss of memory for last year's holiday brings the retrograde memory loss into sharp relief. [16]

These memory deficits have been shown to extend across the entire lifespan and there are significant impairments across a wide range of different types of contextual information including event, place, perceptual and thought/emotion details. [20] When asked to produce personal memories relating to a particular word (for example, "boat"), a 68-year-old epileptic patient failed to retrieve any episodes from his twenties or thirties. His performance on standard tests of anterograde memory was normal." [21]

Autobiographical amnesia may be caused by repeated seizures in the temporal lobe resulting in the progressive "erasure" of memories. [2] Alternatively, autobiographical memory loss may result from subtle changes in the temporal lobe which gives rise to temporal lobe epilepsy and to memory problems. The mechanism and etiology of this phenomenon remain controversial, especially as it is impossible to rule out prior subclinical epileptic activity which could be responsible for a failure to consolidate those seemingly forgotten memories. [19] A recent imaging study that aimed to provide insight into the neural basis of these autobiographical memory deficits revealed that patients had significantly reduced activation in the right medial temporal lobes (and more specifically the right posterior parahippocampal cortex) and effective connectivity analysis indicated that there was reduced connectivity between this right parahippocampal region and the right middle temporal gyrus, which has been linked to semantic memory. [22]

As well as these autobiographical memory deficits, patients have problems with personal semantic information (e.g., names of friends, jobs etc.), particularly for mid-life events. [20] Knowledge for public semantic information such as famous faces, famous events, or new word acquisition appears to be broadly intact. However, for semantic information that has an episodic component, such as knowledge of whether people are dead or alive, patients with TEA often show significant deficits. [20]

Topographical amnesia

Reported in 36% of cases, [2] topographical amnesia refers to the inability of a person to recall the spatial cues necessary to navigate previously familiar terrain, or in some cases, in new places. [21] People with such a symptom find themselves getting lost or confused about directions in circumstances where they would formerly been easily able to find their way. This symptom is problematic for the generally accepted hippocampal loci of TEA memory dysfunctions; such spatial information is generally thought to reside in other neuroanatomical structures. [23]

Treatment

TEA responds well to low doses of medicine used to treat epilepsy, (such as carbamazepine, lamotrigine or sodium valproate) [24] resulting in a cessation of seizure activity in 45 of 47 patients. [4] Medicated patients with continuing seizures experienced them less frequently. [2] The recovery of lost memory, however, is not reported, though there are suggestions that the rate of decay of memory might be reduced with these medications. [2] [3]

Implications for theories of memory

These forms of memory deficit raise issues about the nature of memories in the neuroanatomy and how conflicting observations can be reconciled with either the standard or the multiple trace models. It has been noted that "People with temporal lobe epilepsy provide a natural laboratory for the study of human memory." [15] [25] TEA, as a form of temporal lobe epilepsy, is of particular interest as one must consider both the loss of long-encoded memories (as long as 40 years [14] or one's whole life [23] ) and the simultaneous failure of recently encoded but not immediately short-term memories. The issue of topographical amnesia, which would seem to involve parts of the brain not usually associated with other TEA symptoms, was referred to earlier. These are often considered different kinds of memories with distinct neuroanatomical loci, so that a model to explain both conditions with one etiology is elusive. [14] [15]

The major issues are summarized on the TIME website: [26]

The cluster of memory problems occurring in patients with TEA – episodes of transient amnesia, accelerated forgetting and autobiographical amnesia – challenges both standard and multiple trace models of memory. The features of the amnesic episodes, the high frequency of olfactory hallucinations during attacks and findings from electroencephalography suggest that a medial temporal lobe focus is responsible for the seizures. On the 'standard model' of memory consolidation, which proposes that the medial temporal lobes play a time-limited role in memory processing, accelerated forgetting, occurring over days-1 week (TIME data), is a plausible result of structural or functional pathology in the medial temporal lobes. The associated autobiographical memory impairment is, however, a more puzzling consequence of medial temporal lobe pathology on this theory. It could be that epileptiform activity originating in the medial temporal lobe has the potential to disrupt the distributed neocortical traces required to maintain detailed autobiographical memories. Multiple trace theory, on the other hand predicts that disturbances of anterograde and retrograde episodic memory will go hand in hand. However it is not evident, in this theory, that partial damage to the hippocampus – of the kind that might plausibly cause of the phenomena of TEA – should lead to selective erasure of previously salient autobiographical memories. Thus neither of the leading current models of retrograde memory readily accounts for our observations. [26]

There is support in the pattern of these deficits for "dissociation between the mechanisms subserving anterograde memory and those required to evoke remote episodic memories, and strengthens the evidence for a dissociation between knowledge of public and of personal events." The stability of some memories suggests further that 'focal retrograde amnesia' as it has been termed [7] [16] [19] may be "due to erasure of representations rather than to a defective retrieval mechanism. Whether epileptic activity per se is responsible for this phenomenon requires further investigation." [5] One issue raised by this hypothesis includes whether the reported amnesia in fact predates the TEA attack, and is possibly due to prior subclinical epileptic activity; it also highlights a variety of methodological concerns about studies of amnesia based largely on single case studies and cases with varying etiologies. [1]

ALF and focal retrograde amnesia after TEA offer clues as to the nature of memory consolidation.

According to the standard view of memory consolidation, extensive retrograde amnesia is likely to be the result of damage to cortical memory representations or, more plausibly, the links between individual sensory elements that constitute an autobiographical episode. Recent studies of patients with medial temporal pathology have suggested that the hippocampal formation has a life long role in the storage of autobiographical memories. It is plausible therefore that medial temporal damage, whether occurring as a result of recurrent seizures and/or underlying subtle vascular damage, could result in both accelerated forgetting and retrograde amnesia. Further work investigating the relationships between seizure frequency, EEG activity, structural changes in the temporal lobes, and the severity of accelerated forgetting and autobiographical memory loss, is required to clarify these issues. [16]

This view of consolidation has been disputed, as it seems to suggest consolidation occurs over long spans of time, not just minutes or days, and "requires physiological changes lasting years or decades." [1] Such long-term consolidation processes would seem to require multiple stages of consolidation, which remain hypothetical. [27]

A central concern in theories of memory consolidation is the role of sleep. "(O)ne set of observations suggests that consolidation may occur over any time interval, whereas another body of data suggests that these processes require sleep…. Clearly, both cannot be true. Resolving the inherent conflict between these perspectives strikes at the very heart of how biological mechanisms process memories after their initial encoding." [28] TEA is related to sleep in nearly three-quarters of cases, and persistent memory problems could be the result of nocturnal, subclinical attacks disrupting on-going consolidation processes. Furthermore, as noted, abnormal EEG readings in people with TEA occur primarily in sleep EEG. However, the "reason for the close relationship of TEA with sleep is unclear. It may be that the transition from sleep to waking acts as a trigger to a seizure focus in the medial temporal lobe. Alternatively, amnesia upon waking may reflect persistent post-ictal dysfunction of medial temporal lobe structures following a seizure during sleep." [2]

Related Research Articles

<span class="mw-page-title-main">Henry Molaison</span> American memory disorder patient

Henry Gustav Molaison, known widely as H.M., was an American who had a bilateral medial temporal lobectomy to surgically resect the anterior two thirds of his hippocampi, parahippocampal cortices, entorhinal cortices, piriform cortices, and amygdalae in an attempt to cure his epilepsy. Although the surgery was partially successful in controlling his epilepsy, a severe side effect was that he became unable to form new memories.

<span class="mw-page-title-main">Temporal lobe</span> One of the four lobes of the mammalian brain

The temporal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The temporal lobe is located beneath the lateral fissure on both cerebral hemispheres of the mammalian brain.

In neurology, anterograde amnesia is the inability to create new memories after an event that caused amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact. This is in contrast to retrograde amnesia, where memories created prior to the event are lost while new memories can still be created. Both can occur together in the same patient. To a large degree, anterograde amnesia remains a mysterious ailment because the precise mechanism of storing memories is not yet well understood, although it is known that the regions of the brain involved are certain sites in the temporal cortex, especially in the hippocampus and nearby subcortical regions.

In neurology, retrograde amnesia (RA) is the inability to access memories or information from before an injury or disease occurred. RA differs from a similar condition called anterograde amnesia (AA), which is the inability to form new memories following injury or disease onset. Although an individual can have both RA and AA at the same time, RA can also occur on its own; this 'pure' form of RA can be further divided into three types: focal, isolated, and pure RA. RA negatively affects an individual's episodic, autobiographical, and declarative memory, but they can still form new memories because RA leaves procedural memory intact. Depending on its severity, RA can result in either temporally graded or more permanent memory loss. However, memory loss usually follows Ribot's law, which states that individuals are more likely to lose recent memories than older memories. Diagnosing RA generally requires using an Autobiographical Memory Interview (AMI) and observing brain structure through magnetic resonance imaging (MRI), a computed tomography scan (CT), or electroencephalography (EEG).

<span class="mw-page-title-main">Aura (symptom)</span> Symptom of epilepsy and migraine

An aura is a perceptual disturbance experienced by some with epilepsy or migraine. An epileptic aura is a seizure.

<span class="mw-page-title-main">Temporal lobe epilepsy</span> Chronic focal seizure disorder

In the field of neurology, temporal lobe epilepsy is an enduring brain disorder that causes unprovoked seizures from the temporal lobe. Temporal lobe epilepsy is the most common type of focal onset epilepsy among adults. Seizure symptoms and behavior distinguish seizures arising from the medial temporal lobe from seizures arising from the lateral (neocortical) temporal lobe. Memory and psychiatric comorbidities may occur. Diagnosis relies on electroencephalographic (EEG) and neuroimaging studies. Anticonvulsant medications, epilepsy surgery and dietary treatments may improve seizure control.

<span class="mw-page-title-main">Transient global amnesia</span> Temporary disruption of short-term memory

Transient global amnesia (TGA) is a neurological disorder whose key defining characteristic is a temporary but almost total disruption of short-term memory with a range of problems accessing older memories. A person in a state of TGA exhibits no other signs of impaired cognitive functioning but recalls only the last few moments of consciousness, as well as possibly a few deeply encoded facts of the individual's past, such as their childhood, family, or home perhaps.

Frontal lobe epilepsy (FLE) is a neurological disorder that is characterized by brief, recurring seizures arising in the frontal lobes of the brain, that often occur during sleep. It is the second most common type of epilepsy after temporal lobe epilepsy (TLE), and is related to the temporal form in that both forms are characterized by partial (focal) seizures.

Dissociative amnesia or psychogenic amnesia is a dissociative disorder "characterized by retrospectively reported memory gaps. These gaps involve an inability to recall personal information, usually of a traumatic or stressful nature." In a change from the DSM-IV to the DSM-5, dissociative fugue is now subsumed under dissociative amnesia.

<span class="mw-page-title-main">Electrocorticography</span>

Electrocorticography (ECoG), a type of intracranial electroencephalography (iEEG), is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity from the cerebral cortex. In contrast, conventional electroencephalography (EEG) electrodes monitor this activity from outside the skull. ECoG may be performed either in the operating room during surgery or outside of surgery. Because a craniotomy is required to implant the electrode grid, ECoG is an invasive procedure.

Epilepsy surgery involves a neurosurgical procedure where an area of the brain involved in seizures is either resected, ablated, disconnected or stimulated. The goal is to eliminate seizures or significantly reduce seizure burden. Approximately 60% of all people with epilepsy have focal epilepsy syndromes. In 15% to 20% of these patients, the condition is not adequately controlled with anticonvulsive drugs. Such patients are potential candidates for surgical epilepsy treatment.

Ribot's law of retrograde amnesia was hypothesized in 1881 by Théodule Ribot. It states that there is a time gradient in retrograde amnesia, so that recent memories are more likely to be lost than the more remote memories. Not all patients with retrograde amnesia report the symptoms of Ribot's law.

Kent Cochrane, also known as Patient K.C., was a widely studied Canadian memory disorder patient who has been used as a case study in over 20 neuropsychology papers over the span of 25 years. In 1981, Cochrane was involved in a motorcycle accident that left him with severe anterograde amnesia, as well as temporally graded retrograde amnesia. Like other amnesic patients, Cochrane had his semantic memory intact, but lacked episodic memory with respect to his entire past. As a case study, Cochrane has been linked to the breakdown of the single-memory single-locus hypothesis regarding amnesia, which states that an individual memory is localized to a single location in the brain.

Amnesia is a deficit in memory caused by brain damage or brain diseases, but it can also be temporarily caused by the use of various sedatives and hypnotic drugs. The memory can be either wholly or partially lost due to the extent of damage that was caused.

<span class="mw-page-title-main">Epilepsy in children</span>

Epilepsy is a neurological condition of recurrent episodes of unprovoked epileptic seizures. A seizure is an abnormal neuronal brain activity that can cause intellectual, emotional, and social consequences. Epilepsy affects children and adults of all ages and races, it is one of the most common neurological disorders of the nervous system. As well as, this condition is more common among children than adults affecting about 6 out of 1000 US children that are between the age of 0 to 5 years old. The epileptic seizures can be of different types depending on the part of the brain that was affected, seizures are classified in 2 main types partial seizure or genralized seizure.

People with epilepsy may be classified into different syndromes based on specific clinical features. These features include the age at which seizures begin, the seizure types, and EEG findings, among others. Identifying an epilepsy syndrome is useful as it helps determine the underlying causes as well as deciding what anti-seizure medication should be tried. Epilepsy syndromes are more commonly diagnosed in infants and children. Some examples of epilepsy syndromes include benign rolandic epilepsy, childhood absence epilepsy and juvenile myoclonic epilepsy. Severe syndromes with diffuse brain dysfunction caused, at least partly, by some aspect of epilepsy, are also referred to as epileptic encephalopathies. These are associated with frequent seizures that are resistant to treatment and severe cognitive dysfunction, for instance Lennox-Gastaut syndrome and West syndrome.

Drug-resistant epilepsy (DRE), also known as refractory epilepsy, intractable epilepsy, or pharmacoresistant epilepsy, is diagnosed following a failure of adequate trials of two tolerated and appropriately chosen and used antiepileptic drugs (AEDs) to achieve sustained seizure freedom. The probability that the next medication will achieve seizure freedom drops with every failed AED. For example, after two failed AEDs, the probability that the third will achieve seizure freedom is around 4%. Drug-resistant epilepsy is commonly diagnosed after several years of uncontrolled seizures, however, in most cases, it is evident much earlier. Approximately 30% of people with epilepsy have a drug-resistant form.

<span class="mw-page-title-main">Occipital epilepsy</span> Medical condition

Occipital epilepsy is a neurological disorder that arises from excessive neural activity in the occipital lobe of the brain that may or may not be symptomatic. Occipital lobe epilepsy is fairly rare, and may sometimes be misdiagnosed as migraine when symptomatic. Epileptic seizures are the result of synchronized neural activity that is excessive, and may stem from a failure of inhibitory neurons to regulate properly.

Musicogenic epilepsy is a form of reflex epilepsy with seizures elicited by special stimuli.

Semantic amnesia is a type of amnesia that affects semantic memory and is primarily manifested through difficulties with language use and acquisition, recall of facts and general knowledge. A patient with semantic amnesia would have damage to the temporal lobe.

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