UACA

Not to be confused with Uaçá River.

UACA
Identifiers
Aliases	UACA , NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats
External IDs	OMIM: 612516 MGI: 1919815 HomoloGene: 74297 GeneCards: UACA
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q23 Start 70,654,554 bp [1] End 70,763,558 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 60,701,824 bp [2] End 60,787,652 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon pancreatic ductal cell sural nerve cardia renal medulla ventral tegmental area pylorus nipple trigeminal ganglion subthalamic nucleus Top expressed in otolith organ ankle utricle tibialis anterior muscle esophagus skeletal muscle tissue knee joint interventricular septum soleus muscle quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component extracellular region extracellular exosome cytoskeleton nucleus cytoplasm cytosol Biological process apoptotic signaling pathway regulation of NIK/NF-kappaB signaling biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55075 72565 Ensembl ENSG00000137831 ENSMUSG00000034485 UniProt Q9BZF9 Q8CGB3 RefSeq (mRNA) NM_001008224 NM_018003 NM_028283 NM_001357407 NM_001357408 RefSeq (protein) NP_001008225 NP_060473 NP_082559 NP_001344336 NP_001344337 Location (UCSC) Chr 15: 70.65 – 70.76 Mb Chr 9: 60.7 – 60.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000137831 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, Ohno S, Negi A, Nishimura Y (Feb 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochem. Biophys. Res. Commun. 280 (4): 1169–76. doi:10.1006/bbrc.2001.4189. PMID   11162650.
6. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi: 10.1093/dnares/7.4.271 . PMID   10997877.
7. "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ohkura T, Taniguchi S, Yamada K, et al. (2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochem. Biophys. Res. Commun. 321 (2): 432–40. doi:10.1016/j.bbrc.2004.06.162. PMID   15358194.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.