UBA5

UBA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GUC, 3H8V, 5HKH
Identifiers
Aliases	UBA5 , THIFP1, UBE1DC1, ubiquitin like modifier activating enzyme 5, SCAR24, EIEE44, DEE44
External IDs	OMIM: 610552 MGI: 1913913 HomoloGene: 11738 GeneCards: UBA5
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q22.1 Start 132,654,446 bp [1] End 132,679,794 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F1 Start 103,923,798 bp [2] End 103,940,333 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas Right adrenal gland Left adrenal gland parotid gland anterior pituitary Achilles tendon minor salivary gland secondary oocyte right uterine tube left lobe of thyroid gland Top expressed in lacrimal gland parotid gland seminal vesicula fossa islet of Langerhans supraoptic nucleus facial motor nucleus substantia nigra median eminence condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ubiquitin-like modifier activating enzyme activity ATP binding metal ion binding UFM1 activating enzyme activity Cellular component cytoplasm intracellular membrane-bounded organelle nucleus cytosol Golgi apparatus Biological process regulation of intracellular estrogen receptor signaling pathway protein K69-linked ufmylation response to endoplasmic reticulum stress protein ufmylation neuromuscular process protein modification by small protein conjugation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79876 66663 Ensembl ENSG00000081307 ENSMUSG00000032557 UniProt Q9GZZ9 Q8VE47 RefSeq (mRNA) NM_024818 NM_198329 NM_001320210 NM_001321238 NM_001321239 NM_025692 RefSeq (protein) NP_001307139 NP_001308167 NP_001308168 NP_079094 NP_938143 NP_079968 Location (UCSC) Chr 3: 132.65 – 132.68 Mb Chr 9: 103.92 – 103.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene. ^{[5] [6] [7]}

This gene encodes a member of the E1-like activating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000081307 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032557 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J. 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC   404325 . PMID   15071506.
7. "Entrez Gene: UBE1DC1 ubiquitin-activating enzyme E1-domain containing 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Dou T, Gu S, Liu J, et al. (2006). "Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1". Mol. Biol. Rep. 32 (4): 265–71. doi:10.1007/s11033-005-4822-y. PMID   16328888. S2CID   24569517.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9GZZ9 (Human Ubiquitin-like modifier-activating enzyme 5 (UBE1DC1)) at the PDBe-KB .