UFSP1

UFSP1
Identifiers
Aliases	UFSP1 , UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive)
External IDs	OMIM: 611481 MGI: 1917490 HomoloGene: 80245 GeneCards: UFSP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,889,715 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,293,927 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastrocnemius muscle; ; skeletal muscle tissue; ; right lobe of liver; ; left coronary artery; ; right coronary artery; ; body of pancreas; ; islet of Langerhans; ; fundus; ; left uterine tube;
	Top expressed in
	bone marrow; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; proximal tubule; ; thoracic diaphragm; ; hypothalamus; ; thymus; ; duodenum; ; lip; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	UFM1 hydrolase activity ; cysteine-type peptidase activity ; molecular function ;
Cellular component	extracellular exosome ;
Biological process	proteolysis ; biological process ;
	Sources:Amigo / QuickGO
Orthologs
	402682
	70240
	ENSG00000176125
	ENSMUSG00000051502
	Q6NVU6
	Q9CZP0
	NM_001015072
	NM_027356
	NP_001015072
	NP_081632
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.^[5]

Function

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000176125 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051502 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: UFM1 specific peptidase 1 (inactive)" . Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000176125 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051502 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: UFM1 specific peptidase 1 (inactive)" . Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain .

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