ULBP1

ULBP1
Identifiers
Aliases	ULBP1 , RAET1I, N2DL-1, NKG2DL1, UL16 binding protein 1
External IDs	OMIM: 605697; MGI: 1925027; HomoloGene: 108274; GeneCards: ULBP1; OMA:ULBP1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.1 Start 149,963,943 bp [1] End 149,973,715 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A1 Start 7,390,362 bp [2] End 7,423,638 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium pancreatic ductal cell right lung cerebellar hemisphere right hemisphere of cerebellum upper lobe of left lung islet of Langerhans ventricular zone ganglionic eminence right testis Top expressed in thymus yolk sac granulocyte spermatocyte secondary oocyte placenta embryo epiblast primary oocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function natural killer cell lectin-like receptor binding protein binding Cellular component anchored component of membrane anchored component of plasma membrane endoplasmic reticulum membrane cytosol plasma membrane actin cytoskeleton extracellular space external side of plasma membrane Biological process natural killer cell activation natural killer cell mediated cytotoxicity regulation of immune response immune system process viral process T cell mediated cytotoxicity immune response susceptibility to natural killer cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80329 77777 Ensembl ENSG00000111981 ENSMUSG00000079685 UniProt Q9BZM6 n/a RefSeq (mRNA) NM_025218 NM_001317089 NM_029975 RefSeq (protein) NP_001304018 NP_079494 n/a Location (UCSC) Chr 6: 149.96 – 149.97 Mb Chr 10: 7.39 – 7.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6. ^{[5] [6]} ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus. ^{[5] [6]} The domain structure of ULBP1 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP1 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. ^{[5] [6]} It functions as a stress-induced ligand for NKG2D receptor. ^[5] ULBP1 is, for example, upregulated during HCMV infection. ^[7] Binding of HCMV-encoded UL16 glycoprotein to ULBP1 interferes with cell surface localization of ULBP1; this represents another mechanism by which HCMV-infected cells might escape the immune system. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000111981 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079685 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi: 10.1016/S1074-7613(01)00095-4 . PMID   11239445.
6. Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID   11827464.
7. Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein" . Journal of Immunology. 171 (2): 902–8. doi: 10.4049/jimmunol.171.2.902 . PMID   12847260.

Further reading

• Cerwenka A, Lanier LL (May 2003). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer". Tissue Antigens. 61 (5): 335–43. doi:10.1034/j.1399-0039.2003.00070.x. PMID   12753652.
• Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family". Immunogenetics. 53 (4): 279–87. doi:10.1007/s002510100325. PMID   11491531. S2CID   33695596.
• Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D (Jan 2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells". Journal of Immunology. 168 (2): 671–9. doi: 10.4049/jimmunol.168.2.671 . PMID   11777960.
• Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D (Jun 2003). "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity". The Journal of Experimental Medicine. 197 (11): 1427–39. doi:10.1084/jem.20022059. PMC   2193902 . PMID   12782710.
• Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi: 10.4049/jimmunol.171.2.902 . PMID   12847260.
• Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM (Apr 2004). "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D". The Journal of Experimental Medicine. 199 (7): 1005–10. doi:10.1084/jem.20032194. PMC   2211882 . PMID   15051759.
• Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (Jul 2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D". Journal of Immunology. 173 (2): 1078–84. doi: 10.4049/jimmunol.173.2.1078 . PMID   15240696.
• López-Soto A, Quiñones-Lombraña A, López-Arbesú R, López-Larrea C, González S (Oct 2006). "Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor". The Journal of Biological Chemistry. 281 (41): 30419–30. doi: 10.1074/jbc.M604868200 . PMID   16901903.