UNC45A

UNC45A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DBA
Identifiers
Aliases	UNC45A , GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A, OOHE
External IDs	OMIM: 611219; MGI: 2142246; HomoloGene: 32423; GeneCards: UNC45A; OMA:UNC45A - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.1 Start 90,930,180 bp [1] End 90,954,093 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D2 Start 79,975,040 bp [2] End 79,997,741 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries muscle layer of sigmoid colon Descending thoracic aorta ascending aorta right hemisphere of cerebellum body of uterus skin of leg gastric mucosa stromal cell of endometrium Top expressed in external carotid artery mucous cell of stomach internal carotid artery olfactory epithelium lip Rostral migratory stream molar neural layer of retina tunica media of zone of aorta paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Hsp90 protein binding protein binding cadherin binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Golgi apparatus cytosol nuclear speck Biological process multicellular organism development cell differentiation muscle organ development chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55898 101869 Ensembl ENSG00000140553 ENSMUSG00000030533 UniProt Q9H3U1 Q99KD5 RefSeq (mRNA) NM_001039675 NM_017979 NM_018671 NM_001323619 NM_001323620 NM_001323621 NM_133952 RefSeq (protein) NP_001034764 NP_001310548 NP_001310549 NP_001310550 NP_061141 NP_598713 Location (UCSC) Chr 15: 90.93 – 90.95 Mb Chr 7: 79.98 – 80 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000140553 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030533 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci. 115 (Pt 21): 4013–23. doi:10.1242/jcs.00108. PMID   12356907. S2CID   44196958.
6. "Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

Further reading

• Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. doi:10.2353/ajpath.2007.070325. PMC   2043524 . PMID   17872978.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.
• Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB.26.5.1722-1730.2006. PMC   1430258 . PMID   16478993.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.