UTP20

UTP20
Identifiers
Aliases	UTP20 , DRIM, 1A6/DRIM, small subunit processome component, UTP20 small subunit processome component
External IDs	OMIM: 612822; MGI: 1917933; HomoloGene: 38373; GeneCards: UTP20; OMA:UTP20 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q23.2 Start 101,280,105 bp [1] End 101,386,618 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 88,582,469 bp [2] End 88,662,666 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle tendon of biceps brachii minor salivary glands gonad Achilles tendon ventricular zone secondary oocyte optic nerve stromal cell of endometrium gastrocnemius muscle Top expressed in primitive streak endothelial cell of lymphatic vessel epiblast secondary oocyte primary oocyte tail of embryo mandibular prominence hair follicle maxillary prominence genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm preribosome, small subunit precursor small-subunit processome nucleolus nucleus 90S preribosome nucleoplasm plasma membrane Biological process endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) negative regulation of cell population proliferation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27340 70683 Ensembl ENSG00000120800 ENSMUSG00000004356 UniProt O75691 Q5XG71 RefSeq (mRNA) NM_014503 NM_175158 RefSeq (protein) NP_055318 NP_780367 Location (UCSC) Chr 12: 101.28 – 101.39 Mb Chr 10: 88.58 – 88.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Small subunit processome component 20 homolog is a protein that in humans is encoded by the UTP20 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000120800 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004356 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH (Aug 1998). "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis". Anticancer Res. 18 (3A): 1409–21. PMID   9673349.
6. Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC   539036 . PMID   15590835.
7. Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR (Jul 2003). "A panoramic view of yeast noncoding RNA processing". Cell. 113 (7): 919–33. doi: 10.1016/S0092-8674(03)00466-5 . PMID   12837249. S2CID   10190539.
8. "Entrez Gene: UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)".

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Goodison S, Viars C, Grazzini M, Urquidi V (2004). "The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines". BMC Genomics. 4 (1): 39. doi: 10.1186/1471-2164-4-39 . PMC   222913 . PMID   14503924.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Xing X, Du X, Lu Z, Ning T, Su X, Ke Y (2005). "Characterization of the promoter of 1A6/DRIM, a novel cancer-related gene and identification of its transcriptional activator". Gene. 344: 161–9. doi:10.1016/j.gene.2004.09.036. PMID   15656982.
• Yang L, Zhao J, Lü W, Li Y, Du X, Ning T, Lu G, Ke Y (2006). "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential". Biochem. Biophys. Res. Commun. 334 (3): 884–90. doi:10.1016/j.bbrc.2005.06.179. PMID   16053918.
• Liu J, Du X, Ke Y (2006). "Mapping nucleolar localization sequences of 1A6/DRIM". FEBS Lett. 580 (5): 1405–10. Bibcode:2006FEBSL.580.1405L. doi:10.1016/j.febslet.2006.01.064. PMID   16458307. S2CID   29337295.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Wang Y, Liu J, Zhao H, Lü W, Zhao J, Yang L, Li N, Du X, Ke Y (2007). "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing". Biochim. Biophys. Acta. 1773 (6): 863–8. doi:10.1016/j.bbamcr.2007.04.002. PMID   17498821.