Ubiquitin conjugating enzyme e2 q2

UBE2Q2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZUO
Identifiers
Aliases	UBE2Q2 , ubiquitin conjugating enzyme E2 Q2
External IDs	OMIM: 612501 MGI: 2388672 HomoloGene: 45455 GeneCards: UBE2Q2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	75,901,078 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	55,114,813 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibia; ; palpebral conjunctiva; ; Achilles tendon; ; parietal pleura; ; visceral pleura; ; synovial membrane; ; synovial joint; ; germinal epithelium; ; saphenous vein;
	Top expressed in
	superior cervical ganglion; ; spermatid; ; seminal vesicula; ; interventricular septum; ; parotid gland; ; spermatocyte; ; hand; ; visual cortex; ; cerebellar cortex; ; habenula;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; ATP binding ; ubiquitin-protein transferase activity ; ubiquitin conjugating enzyme activity ;
Cellular component	cytoplasm ; cytosol ;
Biological process	protein K48-linked ubiquitination ; protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	92912
	109161
	ENSG00000140367
	ENSMUSG00000032307
	Q8WVN8
	Q8K2Z8
	NM_001145335 ; NM_001284382 ; NM_173469
	NM_180600 ; NM_001346657 ; NM_001346658
	NP_001138807 ; NP_001271311 ; NP_775740
	NP_001333586 ; NP_001333587 ; NP_850931
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 16, 2023

Ubiquitin conjugating enzyme E2 Q2 is a protein that in humans is encoded by the UBE2Q2 gene. ^[5]

Related Research Articles

Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.

SUMO-conjugating enzyme UBC9 is an enzyme that in humans is encoded by the UBE2I gene. It is also sometimes referred to as "ubiquitin conjugating enzyme E2I" or "ubiquitin carrier protein 9", even though these names do not accurately describe its function.

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.

Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

Ubiquitin conjugating enzyme E2 Z (UBE2Z), also known as UBA6-specific E2 enzyme 1 (USE1), is an enzyme that in humans is encoded by the UBE2Z gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. UBE2Z is an E2 ubiquitin conjugating enzyme and participates in the second step of protein ubiquitination during proteolysis. A genome-wide association study (GWAS) revealed the UBE2Z gene to be associated with chronic kidney disease. The UBE2Z gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140367 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032307 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Ubiquitin conjugating enzyme E2 Q2" . Retrieved 2018-01-18.

Seghatoleslam A, Zambrano A, Millon R, Ganguli G, Argentini M, Cromer A, Abecassis J, Wasylyk B (2006). "Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours". Biochem. Biophys. Res. Commun. 339 (1): 422–9. doi:10.1016/j.bbrc.2005.11.026. PMID 16300736.
Banerjee S, Brooks WS, Crawford DF (2007). "Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents". Oncogene. 26 (45): 6509–17. doi: 10.1038/sj.onc.1210471 . PMID 17471241.
Maeda H, Miyajima N, Kano S, Tsukiyama T, Okumura F, Fukuda S, Hatakeyama S (2009). "Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer". Mol. Cancer Res. 7 (9): 1553–62. doi: 10.1158/1541-7786.MCR-08-0543 . PMID 19723876.
Nikseresht M, Seghatoleslam A, Monabati A, Talei A, Ghalati FB, Owji AA (2010). "Overexpression of the novel human gene, UBE2Q2, in breast cancer". Cancer Genet. Cytogenet. 197 (2): 101–6. doi:10.1016/j.cancergencyto.2009.11.020. PMID 20193842.
Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS (2010). "New loci associated with kidney function and chronic kidney disease". Nat. Genet. 42 (5): 376–84. doi:10.1038/ng.568. PMC 2997674 . PMID 20383146.
Seghatoleslam A, Monabati A, Bozorg-Ghalati F, Nikseresht M, Bordbar MR, Rahvar M, Owji AA (2012). "Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia". Arch Iran Med. 15 (6): 352–5. PMID 22642244.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140367 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032307 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin conjugating enzyme E2 Q2" . Retrieved 2018-01-18.

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Ubiquitin conjugating enzyme e2 q2

Related Research Articles

References

Further reading