VASH1

VASH1
Identifiers
Aliases	VASH1 , KIAA1036, vasohibin 1, TTCP 1
External IDs	OMIM: 609011; MGI: 2442543; HomoloGene: 8941; GeneCards: VASH1; OMA:VASH1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	76,783,015 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	86,738,865 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; C1 segment; ; right auricle; ; apex of heart; ; right coronary artery; ; right adrenal gland; ; amygdala; ; sural nerve; ; left adrenal cortex; ; right hemisphere of cerebellum;
	Top expressed in
	ganglionic eminence; ; olfactory bulb; ; mesencephalon; ; neural tube; ; rhombencephalon; ; ventricular zone; ; cerebellum; ; lens; ; cerebellar cortex; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; actin binding ; metallocarboxypeptidase activity ; carboxypeptidase activity ; peptidase activity ; hydrolase activity ;
Cellular component	cytoplasm ; extracellular region ; apical part of cell ; endoplasmic reticulum ; extracellular space ;
Biological process	negative regulation of angiogenesis ; regulation of cellular senescence ; cell cycle ; negative regulation of lymphangiogenesis ; response to wounding ; regulation of angiogenesis ; negative regulation of blood vessel endothelial cell migration ; angiogenesis ; negative regulation of endothelial cell migration ; negative regulation of endothelial cell proliferation ; placenta blood vessel development ; labyrinthine layer blood vessel development ; proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	22846
	238328
	ENSG00000071246
	ENSMUSG00000021256
	Q7L8A9
	Q8C1W1
	NM_014909
	NM_177354
	NP_055724
	NP_796328
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 16, 2024

Vasohibin-1 is a protein that in humans is encoded by the VASH1 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000071246 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021256 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: VASH1 vasohibin 1".

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Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi: 10.1093/dnares/6.3.197 . PMID 10470851.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi: 10.1038/nature01348 . PMID 12508121.
Watanabe K, Hasegawa Y, Yamashita H, et al. (2004). "Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis". J. Clin. Invest. 114 (7): 898–907. doi:10.1172/JCI21152. PMC 518662 . PMID 15467828.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Shimizu K, Watanabe K, Yamashita H, et al. (2005). "Gene regulation of a novel angiogenesis inhibitor, vasohibin, in endothelial cells". Biochem. Biophys. Res. Commun. 327 (3): 700–6. doi:10.1016/j.bbrc.2004.12.073. PMID 15649403.
Sonoda H, Ohta H, Watanabe K, et al. (2006). "Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin". Biochem. Biophys. Res. Commun. 342 (2): 640–6. doi:10.1016/j.bbrc.2006.01.185. PMID 16488400.
Yamashita H, Abe M, Watanabe K, et al. (2006). "Vasohibin prevents arterial neointimal formation through angiogenesis inhibition". Biochem. Biophys. Res. Commun. 345 (3): 919–25. doi:10.1016/j.bbrc.2006.04.176. PMID 16707096.
Takeda E, Suzuki Y, Yamada T, et al. (2017). "Knockout of vasohibin-1 gene in mice results in healthy longevity with reduced expression of insulin receptor, insulin receptor substrate 1, and insulin receptor substrate 2 in their white adipose tissue". Journal of Aging Research. 2017: 9851380. doi: 10.1155/2017/9851380 . PMC 5358453 . PMID 28367331.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000071246 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021256 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: VASH1 vasohibin 1".

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VASH1

Related Research Articles

References

Further reading