VPS29

Last updated
VPS29
Protein VPS29 PDB 1w24.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VPS29 , DC15, PEP11, DC7, VPS29 retromer complex component, retromer complex component
External IDs OMIM: 606932 MGI: 1928344 HomoloGene: 9433 GeneCards: VPS29
Gene location (Human)
Ideogram human chromosome 12.svg
Chr. Chromosome 12 (human) [1]
Human chromosome 12 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 12q24.11Start110,491,083 bp [1]
End110,502,111 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282150
NM_001282151
NM_016226
NM_057180

NM_019780
NM_001347453
NM_001359226

RefSeq (protein)

NP_001269079
NP_001269080
NP_057310
NP_476528

NP_001334382
NP_062754
NP_001346155

Location (UCSC) Chr 12: 110.49 – 110.5 Mb Chr 5: 122.35 – 122.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex. [5]

Contents

Yeast homolog

The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae). [6]

Function

VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. [7] The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. [8] Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. [6]

Related Research Articles

Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).

SNX1 protein-coding gene in the species Homo sapiens

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

VPS35 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 35 is a protein that in humans is encoded by the VPS35 gene.

VPS4A protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.

VPS4B protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.

SNX2 protein-coding gene in the species Homo sapiens

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.

VPS26A protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.

VPS28 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.

CHMP4B protein-coding gene in the species Homo sapiens

Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.

VPS45 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.

VPS39 protein-coding gene in the species Homo sapiens

hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.

VPS36 protein-coding gene in the species Homo sapiens

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.

VTA1 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein VTA1 homolog is a protein that in humans is encoded by the VTA1 gene.

VPS11 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.

VPS18 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.

VPS13D protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 13D is a protein that in humans is encoded by the VPS13D gene.

VPS52 protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.

VPS33A protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 33A is a protein that in humans is encoded by the VPS33A gene.

VPS25 protein-coding gene in the species Homo sapiens

Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.

VPS26B protein-coding gene in the species Homo sapiens

Vacuolar protein sorting 26 homolog B is a protein in humans that is encoded by the VPS26B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000111237 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029462 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Edgar AJ, Polak JM (November 2000). "Human homologues of yeast vacuolar protein sorting 29 and 35". Biochem. Biophys. Res. Commun. 277 (3): 622–30. doi:10.1006/bbrc.2000.3727. PMID   11062004.
  6. 1 2 "Entrez Gene: VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae)".
  7. Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (December 2000). "Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes". Mol. Biol. Cell. 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC   15060 . PMID   11102511.
  8. Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC   2833274 . PMID   18472259.

Further reading