VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex. [5]
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex. [5]
The homologous protein (one that performs the same function) in yeast is Vacuolar protein sorting 29 homolog (S. cerevisiae). [6]
VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. [7] The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. [8] Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene. [6]
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
Vacuolar protein sorting-associated protein 35 is a protein that in humans is encoded by the VPS35 gene.
Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.
Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.
Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.
Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.
Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.
Charged multivesicular body protein 4b is a protein that in humans is encoded by the CHMP4B gene.
Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.
hVamp6/Vps39-like protein is a protein that in humans is encoded by the VPS39 gene.
Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.
Vacuolar protein sorting-associated protein VTA1 homolog is a protein that in humans is encoded by the VTA1 gene.
Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.
Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.
Vacuolar protein sorting-associated protein 13D is a protein that in humans is encoded by the VPS13D gene.
Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.
Vacuolar protein sorting-associated protein 33A is a protein that in humans is encoded by the VPS33A gene.
Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.
Vacuolar protein sorting 26 homolog B is a protein in humans that is encoded by the VPS26B gene.
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