Vesatolimod

Vesatolimod

Identifiers
IUPAC name 4-amino-2-butoxy-8-{[3-(pyrrolidin-1-ylmethyl)phenyl]methyl}-5,7-dihydropteridin-6-one
CAS Number	1228585-88-3
PubChem CID	46241268
DrugBank	DB12687
ChemSpider	27289075
UNII	O8M467C50G
KEGG	D11003
ChEMBL	ChEMBL2424780
CompTox Dashboard (EPA)	DTXSID40153741
Chemical and physical data
Formula	C22H30N6O2
Molar mass	410.522 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCOC1=NC(=C2C(=N1)N(CC(=O)N2)CC3=CC=CC(=C3)CN4CCCC4)N
InChI InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26) Key:VFOKSTCIRGDTBR-UHFFFAOYSA-N

Vesatolimod (GS-9620) is an antiviral drug developed by Gilead Sciences, which acts as a potent and selective agonist of Toll-like receptor 7 (TLR7), a receptor involved in the regulation of the immune system. It is used to stimulate the immune system, which can increase its ability to combat chronic viral infections. Vesatolimod is in clinical trials to determine whether it is safe and effective in patients with Hepatitis B and HIV/AIDS, ^{[1] [2]} and has also shown activity against other viral diseases such as norovirus and enterovirus 71. ^{[3] [4]}

See also

• Imiquimod
• Motolimod

References

1. Janssen HL, Brunetto MR, Kim YJ, Ferrari C, Massetto B, Nguyen AH, et al. (March 2018). "Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B". Journal of Hepatology. 68 (3): 431–440. doi:10.1016/j.jhep.2017.10.027. PMID   29104121.
2. Riddler SA, Para M, Benson CA, Mills A, Ramgopal M, DeJesus E, et al. (October 2020). "Vesatolimod, a toll-like receptor 7 agonist, induces immune activation in virally suppressed adults with HIV-1". Clinical Infectious Diseases. 72 (11): e815 –e824. doi: 10.1093/cid/ciaa1534 . PMID   33043969.
3. Enosi Tuipulotu D, Netzler NE, Lun JH, Mackenzie JM, White PA (May 2018). "TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation". Antimicrobial Agents and Chemotherapy. 62 (5). doi: 10.1128/AAC.02417-17 . PMC   5923118 . PMID   29530841.
4. Zhang Q, Zhao B, Chen X, Song N, Wu J, Li G, et al. (May 2018). "GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways". Antiviral Research. 153: 39–48. doi:10.1016/j.antiviral.2018.02.002. PMID   29425831. S2CID   4703478.