WBP1

WBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JMQ, 1K5R
Identifiers
Aliases	WBP1 , WBP-1, WW domain binding protein 1
External IDs	OMIM: 606961 MGI: 104710 HomoloGene: 8267 GeneCards: WBP1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,460,891 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,098,540 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; amygdala; ; nucleus accumbens; ; anterior pituitary; ; putamen; ; caudate nucleus; ; hippocampus proper; ; left lobe of thyroid gland; ; fundus;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; ganglionic eminence; ; neural tube; ; medial ganglionic eminence; ; maxillary prominence; ; olfactory epithelium; ; lens; ; otolith organ; ; saccule;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; WW domain binding ;
Cellular component	cellular component ;
Biological process	biological process ;
	Sources:Amigo / QuickGO
Orthologs
	23559
	22377
	ENSG00000239779
	ENSMUSG00000030035
	Q96G27
	P97764
	NM_012477
	NM_001083922 ; NM_001083923 ; NM_016757
	NP_036609
	NP_001077391 ; NP_001077392 ; NP_058037
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 21, 2024

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.^[5]^[6]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.^[6]

Related Research Articles

Dystroglycan is a protein that in humans is encoded by the DAG1 gene.

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.

Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.

Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene.

Endophilin-A2 is a protein that in humans is encoded by the SH3GL1 gene.

NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene.

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.

Formin-binding protein 4 is a protein that in humans is encoded by the FNBP4 gene.

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.

WW domain-binding protein 4 is a protein that in humans is encoded by the WBP4 gene.

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.

The WW domain is a modular protein domain that mediates specific interactions with protein ligands. This domain is found in a number of unrelated signaling and structural proteins and may be repeated up to four times in some proteins. Apart from binding preferentially to proteins that are proline-rich, with particular proline-motifs, [AP]-P-P-[AP]-Y, some WW domains bind to phosphoserine- and phosphothreonine-containing motifs.

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting protein 1 or Rap1-GTP-interacting adapter molecule (RIAM) is a protein that in humans is encoded by the APBB1IP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000239779 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030035 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi: 10.1073/pnas.92.17.7819 . PMC 41237 . PMID 7644498.
1 2 "Entrez Gene: WBP1 WW domain binding protein 1".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins". Oncogene. 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMC 4143251 . PMID 15064722.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394 . PMID 11042109.
Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi: 10.1074/jbc.272.27.17070 . PMID 9202023.
Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi: 10.1074/jbc.272.23.14611 . PMID 9169421.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000239779 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030035 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7644498-5] Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi: 10.1073/pnas.92.17.7819 . PMC 41237 . PMID 7644498.

[entrez-6] 1 2 "Entrez Gene: WBP1 WW domain binding protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

WBP1

Related Research Articles

References

Further reading