WDR45L

WDR45B
Identifiers
Aliases	WDR45B , WDR45L, WIPI-3, WIPI3, WD repeat domain 45B, NEDSBAS
External IDs	OMIM: 609226 MGI: 1914090 HomoloGene: 6028 GeneCards: WDR45B
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,648,553 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	121,245,271 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right uterine tube; ; bronchial epithelial cell; ; Region I of hippocampus proper; ; germinal epithelium; ; lactiferous duct; ; palpebral conjunctiva; ; trachea; ; mucosa of urinary bladder; ; urethra;
	Top expressed in
	neural tube; ; ovary; ; mesencephalon; ; placenta; ; ganglionic eminence; ; heart; ; synovial joint; ; proximal tubule; ; hippocampus proper; ; liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding ; phosphatidylinositol-3,5-bisphosphate binding ; protein binding ; TSC1-TSC2 complex binding ; lipid binding ;
Cellular component	cytosol ; extrinsic component of membrane ; phagophore assembly site membrane ; phagophore assembly site ; lysosome ;
Biological process	protein lipidation ; protein localization to phagophore assembly site ; autophagy of mitochondrion ; autophagy of nucleus ; autophagosome assembly ; cellular response to starvation ; autophagy ;
	Sources:Amigo / QuickGO
Orthologs
	56270
	66840
	ENSG00000141580
	ENSMUSG00000025173
	Q5MNZ6
	Q9CR39
	NM_019613
	NM_025793
	NP_062559
	NP_080069
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 21, 2024

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.^[5]

Structure and function

WIPI-3 is a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein–protein interactions, and a conserved motif for interaction with phospholipids.^[5]

Related Research Articles

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Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin openness and loading of MCM helicase.

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WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.

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Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene and encodes the protein NEDD1.

WD repeat-containing protein 72 is a protein that in humans is encoded by the WDR72 gene. WDR72 contains 7 WD40 repeats, which are predicted to form the blades of a 7 beta propeller structure.

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa, is a protein that in humans is encoded by the WIPI1 gene.

DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141580 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025173 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: WDR45-like".

WDR45L

Contents

Structure and function

See also

Related Research Articles

References

Further reading