WDR83

WDR83
Identifiers
Aliases	WDR83 , MORG1, WD repeat domain 83
External IDs	OMIM: 616850; MGI: 1915086; HomoloGene: 12194; GeneCards: WDR83; OMA:WDR83 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,675,832 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,807,935 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; granulocyte; ; anterior cingulate cortex; ; apex of heart; ; gonad; ; hypothalamus; ; skin of leg;
	Top expressed in
	right kidney; ; ventricular zone; ; neural layer of retina; ; proximal tubule; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; lip; ; embryo; ; primary visual cortex; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; catalytic step 2 spliceosome ; spliceosomal complex ; endosome membrane ; nucleus ;
Biological process	mRNA splicing, via spliceosome ; RNA splicing, via transesterification reactions ; mRNA processing ; MAPK cascade ; RNA splicing ;
	Sources:Amigo / QuickGO
Orthologs
	84292
	67836
	ENSG00000123154
	ENSMUSG00000005150
	Q9BRX9
	Q9DAJ4
	NM_001099737 ; NM_032332
	NM_026399
	NP_001093207 ; NP_115708
	NP_080675
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 22, 2025

WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene. ^[5]

Function

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123154 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005150 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: WD repeat domain 83" . Retrieved 2017-06-15.

Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4) S1355838202021088: 426–39. doi:10.1017/s1355838202021088. PMC 1370266 . PMID 11991638.
Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004). "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. Bibcode:2004PNAS..101.6981V. doi: 10.1073/pnas.0305894101 . PMC 406452 . PMID 15118098.
Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (2006). "The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)". J. Biol. Chem. 281 (13): 8645–55. doi: 10.1074/jbc.M513751200 . PMID 16407229.
Haase D, Keiner S, Mawrin C, Wolf G (2009). "Reduced Morg1 expression in ischemic human brain". Neurosci. Lett. 455 (1): 46–50. doi:10.1016/j.neulet.2009.03.048. PMID 19429104. S2CID 27095825.
Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY (2012). "Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer". Cell Res. 22 (9): 1374–89. doi:10.1038/cr.2012.57. PMC 3434345 . PMID 22491477.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123154 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005150 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WD repeat domain 83" . Retrieved 2017-06-15.

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WDR83

Contents

Function

References

Further reading