WDR83

WDR83
Identifiers
Aliases	WDR83 , MORG1, WD repeat domain 83
External IDs	OMIM: 616850 MGI: 1915086 HomoloGene: 12194 GeneCards: WDR83
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,675,832 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,081,306 bp
Gene ontology
Molecular function	• GO:0001948 protein binding ;
Cellular component	• cytoplasm ; • catalytic step 2 spliceosome ; • spliceosomal complex ; • endosome membrane ; • nucleus ;
Biological process	• mRNA splicing, via spliceosome ; • RNA splicing, via transesterification reactions ; • mRNA processing ; • MAPK cascade ; • RNA splicing ;
	Sources:Amigo / QuickGO
Orthologs
	84292
	67836
	ENSG00000123154
	ENSMUSG00000005150
	Q9BRX9
	Q9DAJ4
	NM_001099737 ; NM_032332
	NM_026399
	NP_001093207 ; NP_115708
	NP_080675
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 24, 2021

WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene. ^[5]

Function

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.

Related Research Articles

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Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene. ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene.

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WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.

WD repeat-containing protein 36 is a protein that in humans is encoded by the WDR36 gene.

Ribosome biogenesis protein WDR12 is a protein that in humans is encoded by the WDR12 gene on chromosome 2. It is ubiquitously expressed in many tissues and cell types. WDR12 participates in ribosome biogenesis and cell proliferation as a component of the PeBoW complex. This protein is associated with cardiovascular diseases such as coronary artery disease and myocardial infarction. The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease.

tRNA -methyltransferase subunit WDR4 is an enzyme that in humans is encoded by the WDR4 gene.

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.

WD repeat-containing protein 37 is a protein that in humans is encoded by the WDR37 gene.

WD repeat-containing protein 62 is a protein that in humans is encoded by the WDR62 gene.

WD repeat-containing protein 46 is a protein that in humans is encoded by the WDR46 gene.

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.

WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause a distinct form of Neurodegeneration with brain iron accumulation (NBIA).

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.

WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123154 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005150 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: WD repeat domain 83" . Retrieved 2017-06-15.

Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/s1355838202021088. PMC 1370266 . PMID 11991638.
Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ (2004). "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. Bibcode:2004PNAS..101.6981V. doi: 10.1073/pnas.0305894101 . PMC 406452 . PMID 15118098.
Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G (2006). "The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)". J. Biol. Chem. 281 (13): 8645–55. doi: 10.1074/jbc.M513751200 . PMID 16407229.
Haase D, Keiner S, Mawrin C, Wolf G (2009). "Reduced Morg1 expression in ischemic human brain". Neurosci. Lett. 455 (1): 46–50. doi:10.1016/j.neulet.2009.03.048. PMID 19429104. S2CID 27095825.
Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY (2012). "Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer". Cell Res. 22 (9): 1374–89. doi:10.1038/cr.2012.57. PMC 3434345 . PMID 22491477.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123154 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005150 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: WD repeat domain 83" . Retrieved 2017-06-15.

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WDR83

Contents

Function

Related Research Articles

References

Further reading