WFDC1

WFDC1
Identifiers
Aliases	WFDC1 , PS20, WAP four-disulfide core domain 1
External IDs	OMIM: 605322 MGI: 1915116 HomoloGene: 10920 GeneCards: WFDC1
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q24.1 Start 84,294,846 bp [1] End 84,329,844 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 120,393,104 bp [2] End 120,414,961 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein right coronary artery seminal vesicula retinal pigment epithelium nipple popliteal artery urethra cardia mucosa of urinary bladder left coronary artery Top expressed in temporal muscle triceps brachii muscle skeletal muscle tissue sternocleidomastoid muscle digastric muscle soleus muscle quadriceps femoris muscle mirror aorta thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity molecular function Cellular component extracellular region extracellular space Biological process negative regulation of wound healing negative regulation of peptidase activity response to estradiol negative regulation of inflammatory response negative regulation of cell growth regulation of cell growth negative regulation of endopeptidase activity negative regulation of epithelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58189 67866 Ensembl ENSG00000103175 ENSMUSG00000023336 UniProt Q9HC57 Q9ESH5 RefSeq (mRNA) NM_001282466 NM_001282467 NM_021197 NM_023395 RefSeq (protein) NP_001269395 NP_001269396 NP_067020 NP_075884 Location (UCSC) Chr 16: 84.29 – 84.33 Mb Chr 8: 120.39 – 120.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WAP four-disulfide core domain protein 1 is a protein that in humans is encoded by the WFDC1 gene. ^{[5] [6]}

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000103175 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023336 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, Rowley DR (Sep 2000). "The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers". Mamm Genome. 11 (9): 767–73. doi:10.1007/s003350010135. PMID   10967136. S2CID   2474630.
6. "Entrez Gene: WFDC1 WAP four-disulfide core domain 1".

Further reading

• Alvarez R, Reading J, King DF, et al. (2008). "WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection". J. Virol. 82 (1): 471–86. doi:10.1128/JVI.00939-07. PMC   2224370 . PMID   17942534.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Watson JE, Kamkar S, James K, et al. (2004). "Molecular analysis of WFDC1/ps20 gene in prostate cancer". Prostate. 61 (2): 192–9. doi:10.1002/pros.20100. PMID   15305342. S2CID   24557545.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• McAlhany SJ, Ressler SJ, Larsen M, et al. (2003). "Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model". Cancer Res. 63 (18): 5859–65. PMID   14522910.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Saffroy R, Riou P, Soler G, et al. (2002). "Analysis of alterations of WFDC1, a new putative tumour suppressor gene, in hepatocellular carcinoma". Eur. J. Hum. Genet. 10 (4): 239–44. doi: 10.1038/sj.ejhg.5200795 . PMID   12032731.