WIPI1

WIPI1
Identifiers
Aliases	WIPI1 , ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
External IDs	OMIM: 609224; MGI: 1261864; HomoloGene: 117983; GeneCards: WIPI1; OMA:WIPI1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q24.2 Start 68,420,948 bp [1] End 68,457,513 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E1|11 72.18 cM Start 109,464,157 bp [2] End 109,502,793 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium sperm gastrocnemius muscle minor salivary glands muscle of thigh biceps brachii left ventricle skeletal muscle tissue sural nerve olfactory zone of nasal mucosa Top expressed in seminal vesicula interventricular septum saccule retinal pigment epithelium muscle of thigh right ventricle stroma of bone marrow submandibular gland otic vesicle granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding androgen receptor binding signaling receptor binding estrogen receptor binding protein binding lipid binding Cellular component cytoplasm phagophore assembly site membrane endosome Golgi apparatus membrane Golgi membrane trans-Golgi network autophagosome membrane endosome membrane cytoskeleton cytoplasmic vesicle clathrin-coated vesicle phagophore assembly site cytosol extrinsic component of membrane Biological process vesicle targeting, trans-Golgi to endosome autophagy IRE1-mediated unfolded protein response macroautophagy autophagy of mitochondrion protein lipidation protein localization to phagophore assembly site autophagy of nucleus autophagosome assembly cellular response to starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55062 52639 Ensembl ENSG00000070540 ENSMUSG00000041895 UniProt Q5MNZ9 Q8R3E3 RefSeq (mRNA) NM_017983 NM_001320772 NM_145940 RefSeq (protein) NP_001307701 NP_060453 NP_666052 Location (UCSC) Chr 17: 68.42 – 68.46 Mb Chr 11: 109.46 – 109.5 Mb PubMed search [3] [4]
Wikidata
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WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene. ^{[5] [6] [7]}

Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. ^{[5] [7]}

See also

• WIPI protein family

References

1. GRCh38: Ensembl release 89: ENSG00000070540 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041895 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: WD repeat domain".
6. Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC   420090 . PMID   15020712.
7. Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID   15602573. S2CID   22642893.

Further reading

• Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009). "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis". PLOS Genet. 5 (11): e1000730. doi: 10.1371/journal.pgen.1000730 . PMC   2777390 . PMID   19936222.
• Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. Bibcode:2010Natur.466...68B. doi:10.1038/nature09204. PMC   2901998 . PMID   20562859.
• Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007). "Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy". FEBS Lett. 581 (18): 3396–404. doi: 10.1016/j.febslet.2007.06.040 . PMID   17618624. S2CID   23430881.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.