WIPI1

WIPI1
Identifiers
Aliases	WIPI1 , ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1
External IDs	OMIM: 609224 MGI: 1261864 HomoloGene: 117983 GeneCards: WIPI1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	68,457,513 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	109,502,793 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; sperm; ; gastrocnemius muscle; ; minor salivary gland; ; biceps brachii; ; left ventricle; ; skeletal muscle tissue; ; sural nerve; ; placenta; ; rectum;
	Top expressed in
	seminal vesicula; ; interventricular septum; ; saccule; ; retinal pigment epithelium; ; right ventricle; ; submandibular gland; ; calvaria; ; skeletal muscle tissue; ; ankle; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding ; phosphatidylinositol-3,5-bisphosphate binding ; androgen receptor binding ; signaling receptor binding ; estrogen receptor binding ; protein binding ; lipid binding ;
Cellular component	cytoplasm ; phagophore assembly site membrane ; endosome ; Golgi apparatus ; membrane ; Golgi membrane ; trans-Golgi network ; autophagosome membrane ; endosome membrane ; cytoskeleton ; cytoplasmic vesicle ; clathrin-coated vesicle ; phagophore assembly site ; cytosol ; extrinsic component of membrane ;
Biological process	vesicle targeting, trans-Golgi to endosome ; autophagy ; IRE1-mediated unfolded protein response ; macroautophagy ; autophagy of mitochondrion ; protein lipidation ; protein localization to phagophore assembly site ; autophagy of nucleus ; autophagosome assembly ; cellular response to starvation ;
	Sources:Amigo / QuickGO
Orthologs
	55062
	52639
	ENSG00000070540
	ENSMUSG00000041895
	Q5MNZ9
	Q8R3E3
	NM_017983 ; NM_001320772
	NM_145940
	NP_001307701 ; NP_060453
	NP_666052
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 28, 2023

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.^[5]^[6]^[7]

Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.^[5]^[7]

Related Research Articles

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.

Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane and is released just before or after autophagosome completion.

Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene.

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.

WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.

WD repeat domain 57 , also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.

WD repeat-containing protein 68 is a protein that in humans is encoded by the DCAF7 gene.

Ribosome biogenesis protein WDR12 is a protein that in humans is encoded by the WDR12 gene on chromosome 2. It is ubiquitously expressed in many tissues and cell types. WDR12 participates in ribosome biogenesis and cell proliferation as a component of the PeBoW complex. This protein is associated with cardiovascular diseases such as coronary artery disease and myocardial infarction. The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease.

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.

WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause a distinct form of Neurodegeneration with brain iron accumulation (NBIA) called Beta-propeller protein-associated neurodegeneration (BPAN).

Bromodomain and WD repeat-containing protein 3 is a protein that in humans is encoded by the BRWD3 gene.

Guanine nucleotide-binding protein subunit beta-like protein 1 is a protein that in humans is encoded by the GNB1L gene.

WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.

WD repeat-containing protein 72 is a protein that in humans is encoded by the WDR72 gene. WDR72 contains 7 WD40 repeats, which are predicted to form the blades of a 7 beta propeller structure.

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.

The WIPI protein family is an evolutionarily conserved family of proteins. WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy, and contain a conserved motif for interaction with phospholipids.

Tetratricopeptide repeat domain 28 is a protein that in humans is encoded by the TTC28 gene.

WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070540 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041895 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: WD repeat domain".
↑ Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090 . PMID 15020712.
1 2 Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.

WIPI1

Contents

Structure and function

See also

Related Research Articles

References

Further reading