WTAP (gene)

WTAP
Identifiers
Aliases	WTAP , Mum2, Wilms tumor 1 associated protein, WT1 associated protein
External IDs	OMIM: 605442 MGI: 1926395 HomoloGene: 68422 GeneCards: WTAP
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.3 Start 159,725,585 bp [1] End 159,756,319 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A1 Start 13,185,683 bp [2] End 13,213,056 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte vena cava amniotic fluid germinal epithelium pericardium parietal pleura caput epididymis ganglionic eminence bone marrow palpebral conjunctiva Top expressed in morula ciliary body medullary collecting duct retinal pigment epithelium condyle fossa renal corpuscle secondary oocyte semi-lunar valve primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nuclear membrane nucleus RNA N6-methyladenosine methyltransferase complex nuclear speck nucleoplasm cytoplasm Biological process RNA splicing cell cycle mRNA processing mRNA methylation regulation of alternative mRNA splicing, via spliceosome multicellular organism development RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9589 60532 Ensembl ENSG00000146457 ENSMUSG00000060475 UniProt Q15007 Q9ER69 RefSeq (mRNA) NM_001270531 NM_001270532 NM_001270533 NM_004906 NM_152857 NM_152858 NM_001113532 NM_001113533 NM_175394 NM_001379058 RefSeq (protein) NP_001257460 NP_001257461 NP_001257462 NP_004897 NP_690596 NP_690597 NP_001107004 NP_001107005 NP_780603 NP_001365987 Location (UCSC) Chr 6: 159.73 – 159.76 Mb Chr 17: 13.19 – 13.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene. ^{[5] [6] [7]}

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform. ^[7]

Interactions

WTAP has been shown to interact with WT1. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000146457 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060475 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi: 10.1093/dnares/2.1.37 . PMID   7788527.
6. Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet. 9 (15): 2231–9. doi: 10.1093/oxfordjournals.hmg.a018914 . PMID   11001926.
7. "Entrez Gene: WTAP Wilms tumor 1 associated protein".

Further reading

• Small TW, Bolender Z, Bueno C, et al. (2007). "Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells". Circ. Res. 99 (12): 1338–46. doi: 10.1161/01.RES.0000252289.79841.d3 . PMID   17095724.
• Horiuchi K, Umetani M, Minami T, et al. (2007). "Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA". Proc. Natl. Acad. Sci. U.S.A. 103 (46): 17278–83. doi: 10.1073/pnas.0608357103 . PMC   1634838 . PMID   17088532.
• Rong Y, Cheng L, Ning H, et al. (2007). "Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor". Cancer Res. 66 (16): 8049–57. doi: 10.1158/0008-5472.CAN-06-1172 . PMID   16912181.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Utsch B, Kaya A, Ozburun A, et al. (2004). "Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias". Scand. J. Urol. Nephrol. 37 (6): 498–501. doi:10.1080/00365590310014517. PMID   14675924. S2CID   34145137.
• Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi: 10.1074/jbc.M212632200 . PMID   12522145.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ortega A, Niksic M, Bachi A, et al. (2003). "Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing". J. Biol. Chem. 278 (5): 3040–7. doi: 10.1074/jbc.M210737200 . PMID   12444081.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.