X8 protein domain

X8
Identifiers
Symbol	X8
Pfam	PF07983
InterPro	IPR012946
SCOP2	1occ / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the X8 domain, is thought to play a role in targeting the plasmodesmata by providing it with structural support. The domain is able to do this since it contains signal sequences for a glycosylphosphatidylinositol (GPI) linkage to the extracellular face of the plasma membrane. This domain is involved in carbohydrate binding. ^[1]

Structure

The X8 domain ^[2] contains 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is also found in an Olive pollen allergen ^[3] as well as at the C terminus of family 17 glycosyl hydrolases. ^[4]

References

1. Simpson C, Thomas C, Findlay K, Bayer E, Maule AJ (2009). "An Arabidopsis GPI-anchor plasmodesmal neck protein with callose binding activity and potential to regulate cell-to-cell trafficking". Plant Cell. 21 (2): 581–94. Bibcode:2009PlanC..21..581S. doi:10.1105/tpc.108.060145. PMC   2660613 . PMID   19223515.
2. Henrissat B, Davies GJ (December 2000). "Glycoside hydrolases and glycosyltransferases. Families, modules, and implications for genomics". Plant Physiol. 124 (4): 1515–9. doi:10.1104/pp.124.4.1515. PMC   1539306 . PMID   11115868.
3. Barral P, Batanero E, Palomares O, Quiralte J, Villalba M, RodrÃguez R (March 2004). "A major allergen from pollen defines a novel family of plant proteins and shows intra- and interspecies [correction of interspecie] cross-reactivity". J. Immunol. 172 (6): 3644–51. doi: 10.4049/jimmunol.172.6.3644 . PMID   15004167.
4. Henrissat B, Coutinho PM, Davies GJ (September 2001). "A census of carbohydrate-active enzymes in the genome of Arabidopsis thaliana". Plant Molecular Biology. 47 (1–2): 55–72. PMID   11554480.

This article incorporates text from the public domain Pfam and InterPro: IPR012946