ZBTB1

ZBTB1
Identifiers
Aliases	ZBTB1 , ZNF909, zinc finger and BTB domain containing 1
External IDs	MGI: 2442326 HomoloGene: 8974 GeneCards: ZBTB1
Gene location (Human)
Chr.	Chromosome 14 (human) [1]
End	64,533,690 bp [1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse) [2]
End	76,396,950 bp [2]
Gene ontology
Molecular function	• DNA binding ; • protein homodimerization activity ; • metal ion binding ; • K63-linked polyubiquitin modification-dependent protein binding ; • protein binding ; • protein heterodimerization activity ; • nucleic acid binding ; • RNA polymerase II transcription factor activity, sequence-specific DNA binding ;
Cellular component	• nuclear body ; • nucleoplasm ; • Cell nucleus ; • nuclear membrane ;
Biological process	• positive regulation of T cell differentiation ; • chromatin remodeling ; • cell differentiation ; • positive regulation of pro-T cell differentiation ; • regulation of transcription, DNA-templated ; • positive regulation of natural killer cell differentiation ; • T cell differentiation in thymus ; • thymus development ; • immune system process ; • cellular response to UV ; • mRNA transcription from RNA polymerase II promoter ; • negative regulation of transcription from RNA polymerase II promoter ; • transcription, DNA-templated ; • positive regulation of T cell mediated immunity ; • translesion synthesis ; • B cell differentiation ; • innate immune response ; • protein homooligomerization ; • DNA repair ; • cellular response to DNA damage stimulus ;
	Sources:Amigo / QuickGO
Orthologs
	22890
	268564
	ENSG00000126804
	ENSMUSG00000033454
	Q9Y2K1
	Q91VL9
	NM_001123329 ; NM_014950
	NM_178744
	NP_001116801 ; NP_055765
	NP_848859
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 01, 2019

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.^[5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.^[6]

Related Research Articles

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene. Like BCL2, BCL3, BCL5, BCL7A, BCL9 and BCL10, it has clinical significance in lymphoma.

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.

Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene. The OSR1 and OSR2 transcription factors participate in the normal development of body parts such as the kidney.

Zinc finger protein 24 is a protein that in humans is encoded by the ZNF24 gene.

Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins, and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.

Zinc finger protein 295 is a protein that in humans is encoded by the ZNF295 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

Zinc finger and BTB domain-containing protein 20 is a protein that in humans is encoded by the ZBTB20 gene.

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.[supplied by OMIM]

Zinc finger and BTB domain-containing protein 40 is a protein that in humans is encoded by the ZBTB40 gene.

Zinc finger and BTB domain containing 11 is a protein that in humans is encoded by the ZBTB11 gene.

Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that directly binds to the double-stranded repeat sequence of telomeres. In humans it is encoded by the ZBTB48 gene.

Zinc finger and BTB domain containing 43 is a protein that in humans is encoded by the ZBTB43 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000126804 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033454 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Zinc finger and BTB domain containing 1".
↑ Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355  . PMID 22753936.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000126804 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033454 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Zinc finger and BTB domain containing 1".

[pmid22753936-6] Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355  . PMID 22753936.