ZC3HAV1

ZC3HAV1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X5Y, 4X52
Identifiers
Aliases	ZC3HAV1 , ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH-type containing, antiviral 1
External IDs	OMIM: 607312 MGI: 1926031 HomoloGene: 10585 GeneCards: ZC3HAV1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q34 Start 139,043,515 bp [1] End 139,132,122 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B1|6 17.72 cM Start 38,282,221 bp [2] End 38,331,538 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cancellous bone endothelial cell visceral pleura blood parietal pleura jejunal mucosa pancreatic ductal cell superficial temporal artery bronchial epithelial cell bone marrow Top expressed in Paneth cell blood cumulus cell spleen hair follicle bone marrow thymus seminal vesicula jejunum right lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding RNA binding cadherin binding NAD+ ADP-ribosyltransferase activity NAD+ binding protein ADP-ribosylase activity Cellular component cytoplasm nucleus cytosol Biological process positive regulation of interferon-alpha production immune system process response to virus positive regulation of mRNA catabolic process negative regulation of viral genome replication positive regulation of RIG-I signaling pathway defense response to virus positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of interferon-beta production protein poly-ADP-ribosylation protein ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56829 78781 Ensembl ENSG00000105939 ENSMUSG00000029826 UniProt Q7Z2W4 Q3UPF5 RefSeq (mRNA) NM_020119 NM_024625 NM_001363491 NM_028421 NM_028864 NM_001347122 RefSeq (protein) NP_064504 NP_078901 NP_001350420 NP_001334051 NP_082697 NP_083140 Location (UCSC) Chr 7: 139.04 – 139.13 Mb Chr 6: 38.28 – 38.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger CCCH-type antiviral protein 1 is a protein that in humans is encoded by the ZC3HAV1 gene. ^{[5] [6] [7]}

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and at least four isoform variants have been described. ^{[8] [7]}

Mechanism of zinc-finger antiviral protein (ZAP) recognition of specific target RNA, and the process by which ZAP coordinates downstream RNA degradation (right). ZAP-RNA complex protein ribbon diagram (left).

References

1. GRCh38: Ensembl release 89: ENSG00000105939 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029826 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gao G, Guo X, Goff SP (Sep 2002). "Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein". Science. 297 (5587): 1703–6. doi:10.1126/science.1074276. PMID   12215647. S2CID   42188205.
6. Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID   12851707.
7. "Entrez Gene: ZC3HAV1 zinc finger CCCH-type, antiviral 1".
8. Ficarelli, Mattia; Neil, Stuart J.D.; Swanson, Chad M. (29 September 2021). "Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System". Annual Review of Virology. 8 (1): 265–283. doi: 10.1146/annurev-virology-091919-104213 . ISSN   2327-056X. PMID   34129371.

Further reading

• Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC   311073 . PMID   11483580.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Bick MJ, Carroll JW, Gao G, et al. (2003). "Expression of the zinc-finger antiviral protein inhibits alphavirus replication". J. Virol. 77 (21): 11555–62. doi:10.1128/JVI.77.21.11555-11562.2003. PMC   229374 . PMID   14557641.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• MacDonald MR, Machlin ES, Albin OR, Levy DE (2007). "The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses". J. Virol. 81 (24): 13509–18. doi:10.1128/JVI.00402-07. PMC   2168828 . PMID   17928353.