ZFX

This article is about the protein. For the flying effects company, see ZFX Inc.

ZFX
Identifiers
Aliases	ZFX , ZNF926, zinc finger protein, X-linked, zinc finger protein X-linked
External IDs	OMIM: 314980; MGI: 99211; HomoloGene: 2561; GeneCards: ZFX; OMA:ZFX - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.11 Start 24,149,173 bp [1] End 24,216,255 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X C3|X 41.48 cM Start 93,118,237 bp [2] End 93,167,308 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve germinal epithelium epithelium of colon monocyte Skeletal muscle tissue of rectus abdominis testicle stromal cell of endometrium tibia Skeletal muscle tissue of biceps brachii Top expressed in medullary collecting duct renal corpuscle ciliary body vestibular sensory epithelium medial ganglionic eminence ureter Ileal epithelium iris primitive streak left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nucleolus Biological process multicellular organism development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription ovarian follicle development germ cell development spermatogenesis fertilization post-embryonic development multicellular organism growth oocyte development homeostasis of number of cells parental behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7543 22764 Ensembl ENSG00000005889 ENSMUSG00000079509 UniProt P17010 P17012 RefSeq (mRNA) NM_001178084 NM_001178085 NM_001178086 NM_001178095 NM_003410 NM_001330327 NM_001044386 NM_011768 NM_001358354 NM_001358355 NM_001358356 NM_001358357 RefSeq (protein) NP_001171555 NP_001171556 NP_001171557 NP_001171566 NP_001317256 NP_003401 NP_001037851 NP_035898 NP_001345283 NP_001345284 NP_001345285 NP_001345286 Location (UCSC) Chr X: 24.15 – 24.22 Mb Chr X: 93.12 – 93.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome. ^[5]

Function

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome (ZFY). It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

Clinical significance

See also: X-linked intellectual disability

The gene is associated with X-linked neurodevelopmental disorder. ^[6]

See also

• Kruppel-like factors

References

1. GRCh38: Ensembl release 89: ENSG00000005889 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079509 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ZFX zinc finger protein, X-linked".
6. Shepherdson, James L.; et al. (7 March 2024). "Variants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt". The American Journal of Human Genetics. 111 (3): 487–508. doi:10.1016/j.ajhg.2024.01.007. PMID   38325380.

Further reading

• North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY". Nucleic Acids Res. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC   328173 . PMID   2041734.
• Mardon G, Luoh SW, Simpson EM, et al. (1990). "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers". Mol. Cell. Biol. 10 (2): 681–8. doi:10.1128/mcb.10.2.681. PMC   360866 . PMID   2105457.
• Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. Bibcode:1990PNAS...87.1681P. doi: 10.1073/pnas.87.5.1681 . PMC   53546 . PMID   2308929.
• Müller G, Schempp W (1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Hum. Genet. 82 (1): 82–4. doi:10.1007/BF00288279. PMID   2497060. S2CID   27908892.
• Schneider-Gädicke A, Beer-Romero P, Brown LG, et al. (1989). "ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation". Cell. 57 (7): 1247–58. doi: 10.1016/0092-8674(89)90061-5 . PMID   2500252.
• Schneider-Gädicke A, Beer-Romero P, Brown LG, et al. (1990). "Putative transcription activator with alternative isoforms encoded by human ZFX gene". Nature. 342 (6250): 708–11. doi:10.1038/342708a0. PMID   2512506. S2CID   4334544.
• Taylor DM, Ray PF, Ao A, et al. (1998). "Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage". Mol. Reprod. Dev. 48 (4): 442–8. doi:10.1002/(SICI)1098-2795(199712)48:4<442::AID-MRD4>3.0.CO;2-Q. PMID   9364438. S2CID   33046919.
• Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals". Nature. 409 (6820): 614–8. Bibcode:2001Natur.409..614M. doi:10.1038/35054550. PMID   11214319. S2CID   4373847.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi: 10.1093/molbev/msh027 . PMID   14660691.
• Poloumienko A (2004). "Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY". Genome. 47 (1): 74–83. doi:10.1139/g03-099. PMID   15060604.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.