ZHX1

Last updated

ZHX1
Protein ZHX1 PDB 2ecb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZHX1 , zinc fingers and homeoboxes 1
External IDs OMIM: 604764; MGI: 109271; HomoloGene: 5225; GeneCards: ZHX1; OMA:ZHX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017926
NM_007222

NM_001042438
NM_009572

RefSeq (protein)

NP_001017926
NP_009153

NP_001035903
NP_033598

Location (UCSC) Chr 8: 123.25 – 123.28 Mb Chr 15: 57.91 – 57.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene. [5] [6]

Contents

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein. [6]

Interactions

ZHX1 has been shown to interact with NFYA. [5] [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165156 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022361 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Yamada K, Printz RL, Osawa H, Granner DK (August 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochemical and Biophysical Research Communications. 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID   10441475. S2CID   35415109.
  6. 1 2 "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1".
  7. Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Letters. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID   10571058. S2CID   28576187.

Further reading