ZMIZ1

ZMIZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AIZ
Identifiers
Aliases	ZMIZ1 , MIZ, RAI17, TRAFIP10, ZIMP10, hZIMP10, zinc finger MIZ-type containing 1, NEDDFSA
External IDs	OMIM: 607159; MGI: 3040693; HomoloGene: 10667; GeneCards: ZMIZ1; OMA:ZMIZ1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.3 Start 79,068,966 bp [1] End 79,316,519 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A3 Start 25,459,609 bp [2] End 25,667,167 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve tibia seminal vesicula inferior olivary nucleus ganglionic eminence endothelial cell synovial joint urethra vulva hair follicle Top expressed in Rostral migratory stream gastrula genital tubercle stroma of bone marrow epithelium of stomach molar tail of embryo cumulus cell ventricular zone olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding Cellular component cytoplasm nucleus nuclear speck intracellular membrane-bounded organelle nucleoplasm Biological process vasculogenesis heart morphogenesis developmental growth in utero embryonic development regulation of transcription, DNA-templated transcription, DNA-templated vitellogenesis artery morphogenesis positive regulation of fibroblast proliferation positive regulation of T cell differentiation positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57178 328365 Ensembl ENSG00000108175 ENSMUSG00000007817 UniProt Q9ULJ6 Q6P1E1 RefSeq (mRNA) NM_020338 NM_001033402 NM_183208 NM_001310666 RefSeq (protein) NP_065071 NP_001297595 NP_899031 Location (UCSC) Chr 10: 79.07 – 79.32 Mb Chr 14: 25.46 – 25.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger MIZ domain-containing protein 1 is a protein that in humans is encoded by the ZMIZ1 gene. ^[5]

Interactions

ZMIZ1 has been shown to interact with Androgen receptor. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000108175 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007817 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ZMIZ1 zinc finger, MIZ-type containing 1".
6. Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, Lim B, Sun Z (Nov 2003). "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci". EMBO J. 22 (22): 6101–6114. doi:10.1093/emboj/cdg585. PMC   275443 . PMID   14609956.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID   8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–345. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, Lim B, Sun Z (2004). "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci". EMBO J. 22 (22): 6101–6114. doi:10.1093/emboj/cdg585. PMC   275443 . PMID   14609956.
• Li X, Thyssen G, Beliakoff J, Sun Z (2006). "The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity". J. Biol. Chem. 281 (33): 23748–23756. doi: 10.1074/jbc.M508365200 . PMID   16777850.
• Cappuzzello C, Melchionna R, Mangoni A, Tripodi G, Ferrari P, Torielli L, Arcelli D, Helmer-Citterich M, Bianchi G, Capogrossi MC, Napolitano M (2007). "Role of rat alpha adducin in angiogenesis: null effect of the F316Y polymorphism". Cardiovasc. Res. 75 (3): 608–617. doi: 10.1016/j.cardiores.2007.04.020 . PMID   17512505.
• Lee J, Beliakoff J, Sun Z (2007). "The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor". Nucleic Acids Res. 35 (13): 4523–4534. doi:10.1093/nar/gkm476. PMC   1935018 . PMID   17584785.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9ULJ6 (Zinc finger MIZ domain-containing protein 1) at the PDBe-KB .