ZNF184

Last updated
ZNF184
Identifiers
Aliases ZNF184 , kr-ZNF3, zinc finger protein 184
External IDs OMIM: 602277 MGI: 1922244 HomoloGene: 113602 GeneCards: ZNF184
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007149
NM_001318891
NM_001318892
NM_001318893
NM_001347832

Contents

NM_183014
NM_001360886

RefSeq (protein)

NP_001305820
NP_001305821
NP_001305822
NP_001334761
NP_009080

NP_898835
NP_001347815

Location (UCSC) Chr 6: 27.45 – 27.47 Mb Chr 13: 22.13 – 22.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 184, also known as ZNF184, is a protein that in humans is encoded by the ZNF184 gene [5] on chromosome 6. It was first identified by Goldwurm et al. in 1996. [6]

The National Center for Biotechnology Information (NCBI) Gene database entry [5] for ZNF184 identifies conserved domains KRAB_A (Krüppel associated box) near the N-terminus and Zn-finger (Zinc finger) at the C-terminus of the translated protein. The former is associated with transcription repression [7] and the latter with DNA binding (see Zinc finger).

Domains and Structure

The figure below is a reformatted and annotated conceptual translation display of ZNF184's Consensus CDS. [8] CCDS displays exons in alternating black and blue font, with red indicating a residue coded across a splice boundary.

ZNF184 has 19 zinc finger motifs at the end of its final and longest exon. The figure shows regularity among the fingers in this protein, including the 2 columns of green-highlighted Cysteine residues and the 2 columns of blue-highlighted His residues which are the reason this type of zinc finger is called C2H2. Light grey highlighted columns (one with all F; one with mostly L, and F substitutions) are highly conserved hydrophobic residues within the zinc finger motif. The other light grey highlighted column (mostly K, with a similar R substitution) is an example of fairly strong conservation in the coil sections connecting adjacent fingers.

Near the N-terminus is a KRAB_A domain followed by a KRAB_B domain. KRAB_A has a shorter α-Helix followed by a longer α-Helix. The KRAB_A motif in a zinc finger protein is known to bind with a KAP-1 protein (aka TRIM28) to accomplish a transcription repressor function, however a gene so regulated by ZNF184 has yet to be identified. The length-11 finger helices are indicated, as well as the overlapping 7-residue section in each finger which binds targeted DNA (if the finger is functioning).

Reformatted Protein ZNF184 tandem 19.png
Reformatted Protein

Related Research Articles

Krüppel associated box Protein domain

The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors. The KRAB domain typically consists of about 75 amino acid residues, while the minimal repression module is approximately 45 amino acid residues. It is predicted to function through protein-protein interactions via two amphipathic helices. The most prominent interacting protein is called TRIM28 initially visualized as SMP1, cloned as KAP1 and TIF1-beta. Substitutions for the conserved residues abolish repression.

ZNF281 Protein-coding gene in the species Homo sapiens

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.

ZNF146 Protein-coding gene in the species Homo sapiens

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene.

ZNF43 Protein-coding gene in the species Homo sapiens

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.

ZNF10 Protein-coding gene in the species Homo sapiens

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.

ZNF274 Protein-coding gene in the species Homo sapiens

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.

ZNF649 Protein-coding gene in the species Homo sapiens

Zinc finger protein 649 is a protein that in humans is encoded by the ZNF649 gene on Human Chromozone 19 containing 5 exons.

ZKSCAN1

Zinc finger protein with KRAB and SCAN domains 1 is a protein that in humans is encoded by the ZKSCAN1 gene.

ZNF267

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

ZNF19 Protein-coding gene in the species Homo sapiens

Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.

ZNF41 Protein-coding gene in the species Homo sapiens

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.

ZNF268

Zinc finger protein 268 is a protein that in humans is encoded by the ZNF268 gene.

ZNF331 Protein-coding gene in the species Homo sapiens

Zinc finger protein 331 is a protein that in humans is encoded by the ZNF331 gene.

ZNF83 Protein-coding gene in the species Homo sapiens

Zinc finger protein 83 is a protein that in humans is encoded by the ZNF83 gene.

ZNF8 Protein-coding gene in the species Homo sapiens

Zinc finger protein 8 is a protein that in humans is encoded by the ZNF8 gene.

ZNF23

Zinc finger protein 23 is a protein that in humans is encoded by the ZNF23 gene.

ZNF133

Zinc finger protein 133 is a protein that in humans is encoded by the ZNF133 gene.

ZNF160 Protein-coding gene in the species Homo sapiens

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.

Zinc finger protein 208 Protein-coding gene in the species Homo sapiens

Zinc finger protein 208 is a protein that in humans is encoded by the ZNF208 gene.

ZNF548 Protein-coding gene in the species Homo sapiens

Zinc Finger Protein 548 (ZNF548) is a human protein encoded by the ZNF548 gene which is located on chromosome 19. It is found in the nucleus and is hypothesized to play a role in the regulation of transcription by RNA Polymerase II. It belongs to the Krüppel C2H2-type zinc-finger protein family as it contains many zinc-finger repeats.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000096654 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006720 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: zinc finger protein 184".
  6. Goldwurm S, Menzies ML, Banyer JL, Powell LW, Jazwinska EC (1997-03-15). "Identification of a novel Krueppel-related zinc finger gene (ZNF184) mapping to 6p21.3". Genomics. 40 (3): 486–9. doi:10.1006/geno.1996.4583. PMID   9073517.
  7. Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher III FJ (2000-03-30). "Biochemical Analysis of the Kruppel-associated Box (KRAB) Transcriptional Repression Domain". Journal of Biological Chemistry. 275 (24): 18000–10. doi: 10.1074/jbc.M001499200 . PMID   10748030.
  8. "Consensus CDS: zinc finger protein 184".

Further reading