ZNF444

ZNF444
Identifiers
Aliases	ZNF444 , EZF-2, EZF2, ZSCAN17, zinc finger protein 444
External IDs	OMIM: 607874 MGI: 1923365 HomoloGene: 10139 GeneCards: ZNF444
Gene location (Human)
Chr.	Chromosome 19 (human)
End	56,160,893 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	6,196,810 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; vena cava; ; right uterine tube; ; right lobe of liver; ; cerebellar vermis; ; body of pancreas; ; thoracic diaphragm; ; cingulate gyrus; ; pancreatic ductal cell; ; fundus;
	Top expressed in
	yolk sac; ; spermatocyte; ; superior frontal gyrus; ; proximal tubule; ; neural tube; ; thymus; ; spermatid; ; ganglionic eminence; ; lip; ; mirror;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding ; metal ion binding ; DNA-binding transcription factor activity ; DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; positive regulation of transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	55311
	72667
	ENSG00000167685
	ENSMUSG00000044876
	Q8N0Y2
	n/a
	NM_001253792 ; NM_018337
	NM_001146024 ; NM_028316
	NP_001240721 ; NP_060807 ; NP_001240721.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2023

Zinc finger protein 444 is a protein that in humans is encoded by the ZNF444 gene. ^[5]

Function

This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low-density lipoprotein (Ac-LDL) (Adachi H, Tsujimoto M (2002). "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2". J Biol Chem. 277 (27): 24014–21. doi: 10.1074/jbc.M201854200 . PMID 11978792.). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.

Related Research Articles

Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene.

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.

Tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), is a protein that in humans, mice and rats is encoded by the ZFP36 gene. It is a member of the TIS11 family, along with butyrate response factors 1 and 2.

Endothelial protein C receptor (EPCR) also known as activated protein C receptor is a protein that in humans is encoded by the PROCR gene. PROCR has also recently been designated CD201.

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.

Myc-associated zinc finger protein is a protein that in humans is encoded by the MAZ gene.

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene. Schizophrenia susceptibility has been associated with a mutation in this protein.

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.[supplied by OMIM]

Stabilin-2 is a protein that in humans is encoded by the STAB2 gene.

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

Zinc finger protein 398 is a protein that in humans is encoded by the ZNF398 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167685 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044876 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger protein 444" . Retrieved 2017-04-14.

ZNF444

Contents

Function

Related Research Articles

References

Further reading