ZNF746

ZNF746
Identifiers
Aliases	ZNF746 , P.A.R.I.S, PARIS, zinc finger protein 746
External IDs	OMIM: 613914; MGI: 1916478; HomoloGene: 19783; GeneCards: ZNF746; OMA:ZNF746 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q36.1 Start 149,472,696 bp [1] End 149,497,817 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.3 Start 48,039,329 bp [2] End 48,063,527 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte mucosa of ileum spleen monocyte bone marrow cell left testis stromal cell of endometrium right testis sural nerve Top expressed in otic placode saccule otic vesicle granulocyte genital tubercle blood spermatocyte condyle Paneth cell fossa More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding ubiquitin protein ligase binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm intracellular anatomical structure nucleus Biological process negative regulation of transcription, DNA-templated positive regulation of neuron death negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 155061 69228 Ensembl ENSG00000181220 ENSMUSG00000057691 UniProt Q6NUN9 Q3U133 RefSeq (mRNA) NM_001163474 NM_152557 NM_001363517 NM_001394198 NM_001163475 NM_001347142 NM_001362062 RefSeq (protein) NP_001156946 NP_689770 NP_001350446 NP_001156947 NP_001334071 NP_001348991 Location (UCSC) Chr 7: 149.47 – 149.5 Mb Chr 6: 48.04 – 48.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 746 also known as Parkin-interacting substrate (PARIS) is a zinc finger protein that, in humans, is encoded by the ZNF746 gene and is involved in the neurodegeneration of Parkinson's disease. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000181220 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057691 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, et al. (March 2011). "PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease". Cell. 144 (5): 689–702. doi: 10.1016/j.cell.2011.02.010 . PMC   3063894 . PMID   21376232.
6. "Entrez Gene: ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]".