ZNF746

ZNF746
Identifiers
Aliases	ZNF746 , P.A.R.I.S, PARIS, zinc finger protein 746
External IDs	OMIM: 613914 MGI: 1916478 HomoloGene: 19783 GeneCards: ZNF746
Gene location (Human)
Chr.	Chromosome 7 (human)
End	149,497,817 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	48,063,527 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; monocyte; ; bone marrow cells; ; stromal cell of endometrium; ; sural nerve; ; secondary oocyte; ; pancreatic ductal cell; ; gastric mucosa; ; placenta;
	Top expressed in
	otic placode; ; saccule; ; blood; ; spermatocyte; ; condyle; ; Paneth cell; ; fossa; ; pyloric antrum; ; foot; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; protein binding ; ubiquitin protein ligase binding ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; intracellular anatomical structure ; nucleus ;
Biological process	negative regulation of transcription, DNA-templated ; positive regulation of neuron death ; negative regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	155061
	69228
	ENSG00000181220
	ENSMUSG00000057691
	Q6NUN9
	Q3U133
	NM_001163474 ; NM_152557 ; NM_001363517 ; NM_001394198
	NM_001163475 ; NM_001347142 ; NM_001362062
	NP_001156946 ; NP_689770 ; NP_001350446
	NP_001156947 ; NP_001334071 ; NP_001348991
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Zinc finger protein 746 also known as Parkin-interacting substrate (PARIS) is a zinc finger protein that, in humans, is encoded by the ZNF746 gene and is involved in the neurodegeneration of Parkinson's disease.^[5]^[6]

Related Research Articles

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Zinc finger protein 330 is a protein that in humans is encoded by the ZNF330 gene.

Zinc finger protein 7 is a protein that in humans is encoded by the ZNF7 gene.

Zinc finger protein 22 is a protein that in humans is encoded by the ZNF22 gene.

Zinc finger protein 23 is a protein that in humans is encoded by the ZNF23 gene.

Zing finger protein 644 (ZNF644) also known as zinc finger motif enhancer-binding protein 2 (Zep-2) is a protein that in humans is encoded by the ZNF644 gene.

Zinc finger protein 266 is a protein that in humans is encoded by the ZNF266 gene.

Zinc finger protein 208 is a protein that in humans is encoded by the ZNF208 gene.

Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.

Zinc finger protein 93 is a protein that in humans is encoded by the ZNF93 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000181220 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057691 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, et al. (March 2011). "PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease". Cell. 144 (5): 689–702. doi: 10.1016/j.cell.2011.02.010 . PMC 3063894 . PMID 21376232.
↑ "Entrez Gene: ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000181220 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057691 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10718198-5] Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O, et al. (March 2011). "PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease". Cell. 144 (5): 689–702. doi: 10.1016/j.cell.2011.02.010 . PMC 3063894 . PMID 21376232.

[entrez-6] "Entrez Gene: ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]".

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