Zinc finger and scan domain containing 4

ZSCAN4
Identifiers
Aliases	ZSCAN4 , ZNF494, zinc finger and SCAN domain containing 4
External IDs	OMIM: 613419; MGI: 3708485; HomoloGene: 138332; GeneCards: ZSCAN4; OMA:ZSCAN4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.43 Start 57,668,935 bp [1] End 57,679,152 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 A1 Start 11,131,842 bp [2] End 11,136,245 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta apex of heart olfactory zone of nasal mucosa right uterine tube skin of abdomen urinary bladder skin of leg minor salivary glands skin of hip body of stomach Top expressed in zygote secondary oocyte epiblast spleen lung More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component telomere chromosome nucleus Biological process telomere maintenance via telomere lengthening regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of mitotic recombination regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 201516 665902 Ensembl ENSG00000180532 ENSMUSG00000070828 UniProt Q8NAM6 Q3URS2 RefSeq (mRNA) NM_152677 NM_001384833 NM_001110316 RefSeq (protein) NP_689890 NP_001103786 Location (UCSC) Chr 19: 57.67 – 57.68 Mb Chr 7: 11.13 – 11.14 Mb PubMed search [3] [4]
Wikidata
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Zinc finger and SCAN domain containing 4 is a protein that in humans is encoded by the ZSCAN4 gene. ^[5]

Function

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000180532 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070828 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger and SCAN domain containing 4" . Retrieved 2017-06-05.
6. Ko, Minoru S. H.; Wersto, Robert P.; Indig, Fred E.; Yang, Hsih-Te; Hoang, Hien G.; Carole A. Stagg; Lee, Sung-Lim; Thomas, Marshall; Nishiyama, Akira (April 2010). "Zscan4 regulates telomere elongation and genomic stability in ES cells". Nature. 464 (7290): 858–863. Bibcode:2010Natur.464..858Z. doi:10.1038/nature08882. ISSN   1476-4687. PMC   2851843 . PMID   20336070.

Further reading

• Lee K, Gollahon LS (2014). "Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status". Cancer Biol. Ther. 15 (8): 1094–105. doi:10.4161/cbt.29220. PMC   4119077 . PMID   24840609.
• Lee K, Gollahon LS (2015). "ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity". Biochem. Biophys. Res. Commun. 466 (4): 644–9. Bibcode:2015BBRC..466..644L. doi:10.1016/j.bbrc.2015.09.107. PMID   26403970.
• Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS (2017). "Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos". In Vitro Cell. Dev. Biol. Anim. 53 (2): 179–190. doi:10.1007/s11626-016-0097-y. PMC   5311086 . PMID   27699651.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.