Zinc finger homeobox 2

ZFHX2
Identifiers
Aliases	ZFHX2 , ZFH-5, ZNF409, ZFH5, MARSIS, zinc finger homeobox 2
External IDs	OMIM: 617828 MGI: 2686934 HomoloGene: 52657 GeneCards: ZFHX2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,556,192 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,329,781 bp
RNA expression pattern
	Top expressed in
	sperm; ; sural nerve; ; right uterine tube; ; ganglionic eminence; ; anterior pituitary; ; Brodmann area 9; ; prefrontal cortex; ; Brodmann area 23; ; hippocampus proper; ; hypothalamus;
	Top expressed in
	superior frontal gyrus; ; urethra; ; cerebellar cortex; ; male urethra; ; neural tube; ; superior cervical ganglion; ; ganglionic eminence; ; enteric nervous system; ; trigeminal ganglion; ; mesencephalon;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding ; DNA binding ; zinc ion binding ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ;
Cellular component	nucleus ;
Biological process	adult behavior ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; negative regulation of transcription by RNA polymerase II ; positive regulation of transcription, DNA-templated ; regulation of sensory perception of pain ;
	Sources:Amigo / QuickGO
Orthologs
	85446
	239102
	ENSG00000136367
	ENSMUSG00000040721
	Q9C0A1
	Q2MHN3
	NM_033400
	NM_001039198
	NP_207646
	NP_001034287
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 23, 2023

Zinc finger homeobox 2 is a protein that in humans is encoded by the ZFHX2 gene.^[5] It has been implicated in pain insensitivity.^[6]

Related Research Articles

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Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.

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Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

Zinc finger protein 330 is a protein that in humans is encoded by the ZNF330 gene.

Zinc finger protein 22 is a protein that in humans is encoded by the ZNF22 gene.

Zinc finger and SCAN domain-containing protein 21 is a protein that in humans is encoded by the ZSCAN21 gene.

Zinc finger and BTB domain-containing protein 40 is a protein that in humans is encoded by the ZBTB40 gene.

Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene. The DBX1 gene is a transcription factor gene that is pivotal in interneuron differentiation in the ventral spinal cord.

Iroquois-class homeodomain protein IRX-6, also known as Iroquois homeobox protein 6, is a protein that in humans is encoded by the IRX6 gene.

ZEB2-AS1 is a long non-coding RNA, which is overlapping and antisense to the ZEB2 gene. It overlaps the 5′ splice site of an intron within the 5′UTR of the ZEB2 gene. This intron contains an internal ribosome entry site (IRES), which is necessary for ZEB2 expression. ZEB2-AS1 prevents the splicing of this intron, and therefore activates ZEB2 expression.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136367 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040721 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger homeobox 2".
↑ Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. (December 2017). "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" (PDF). Brain. 141 (2): 365–376. doi:10.1093/brain/awx326. PMC 5837393 . PMID 29253101.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136367 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040721 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger homeobox 2".

[HabibMatsuyama2017-6] Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. (December 2017). "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" (PDF). Brain. 141 (2): 365–376. doi:10.1093/brain/awx326. PMC 5837393 . PMID 29253101.

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