Zinc finger protein 516

ZNF516
Identifiers
Aliases	ZNF516 , HsT287, zinc finger protein 516
External IDs	OMIM: 615114 MGI: 2443957 HomoloGene: 37122 GeneCards: ZNF516
Gene location (Human)
Chr.	Chromosome 18 (human)
End	76,495,242 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	83,023,439 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; canal of the cervix; ; right uterine tube; ; monocyte; ; left uterine tube; ; seminal vesicula; ; blood; ; myometrium; ; anterior pituitary; ; tibial nerve;
	Top expressed in
	hand; ; ascending aorta; ; aortic valve; ; islet of Langerhans; ; trigeminal ganglion; ; abdominal wall; ; otolith organ; ; pituitary gland; ; vas deferens; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity ; sequence-specific DNA binding ; DNA binding ; cis-regulatory region sequence-specific DNA binding ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	multicellular organism development ; positive regulation of transcription, DNA-templated ; response to cold ; adipose tissue development ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; signal transduction ; brown fat cell differentiation ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; positive regulation of cold-induced thermogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	9658
	329003
	ENSG00000101493
	ENSMUSG00000058881
	Q92618
	Q7TSH3
	NM_014643
	NM_001177464 ; NM_183033
	NP_055458
	NP_001170935 ; NP_898854
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2023

Zinc finger protein 516 is a protein that in humans is encoded by the ZNF516 gene.^[5]

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.

Related Research Articles

Zinc finger transcription factor Trps1 is a protein that in humans is encoded by the TRPS1 gene.

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.

Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene. KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases superfamily.

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.

Lysine-specific demethylase 2A (KDM2A) also known as F-box and leucine-rich repeat protein 11 (FBXL11) is an enzyme that in humans is encoded by the KDM2A gene. KDM2A is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.

Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene. KDM5C belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

PHD finger protein 3 is a protein that in humans is encoded by the PHF3 gene.

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

Zinc finger protein 655 is a protein that in humans is encoded by the ZNF655 gene.

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.

Zinc finger protein 24 is a protein that in humans is encoded by the ZNF24 gene.

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.

Zinc finger protein 473 is a protein that in humans is encoded by the ZNF473 gene.

Zinc finger and BTB domain-containing protein 40 is a protein that in humans is encoded by the ZBTB40 gene.

Zing finger protein 644 (ZNF644) also known as zinc finger motif enhancer-binding protein 2 (Zep-2) is a protein that in humans is encoded by the ZNF644 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101493 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058881 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger protein 516".

Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML (January 2013). "GWAS of dental caries patterns in the permanent dentition". Journal of Dental Research. 92 (1): 38–44. doi:10.1177/0022034512463579. PMC 3521449 . PMID 23064961.
Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (April 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
Lee MG, Wynder C, Cooch N, Shiekhattar R (September 2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794. S2CID 4396351.
Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (September 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609 . PMID 20834067.
O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, Cavalleri GL, Conlon PJ (2013). "A genome-wide association study of recipient genotype and medium-term kidney allograft function". Clinical Transplantation. 27 (3): 379–87. doi:10.1111/ctr.12093. PMID 23432519. S2CID 13087946.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101493 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058881 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger protein 516".

[1]

[2]

[3]

[4]

[5]

Zinc finger protein 516

Contents

Function

Related Research Articles

References

Further reading