Zinc picolinate

Last updated
Zinc picolinate
Zinc picolinate.svg
CSD CIF ZNPICH01.jpg
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.132.913 OOjs UI icon edit-ltr-progressive.svg
PubChem CID
UNII
  • InChI=1S/2C6H5NO2.Zn/c2*8-6(9)5-3-1-2-4-7-5;/h2*1-4H,(H,8,9);/q;;+2/p-2
    Key: NHVUUBRKFZWXRN-UHFFFAOYSA-L
  • C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Zn+2]
Properties
C12H12N2O6Zn
Molar mass 345.62 g·mol−1
Hazards
GHS labelling:
GHS-pictogram-exclam.svg GHS-pictogram-pollu.svg
Warning
H302, H315, H319, H335, H410
P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Zinc picolinate (or ZnPic) is the zinc coordination complex derived from picolinic acid and zinc(II). It has the formula Zn(NC5H4CO2)2(H2O)2. The complex adopts an octahedral molecular geometry, containing two bidentate picolinate ligands (conjugate base of picolinic acid) and two aquo ligands. Additionally, two water of crystallization are present, thus the compound crystallizes with the formula Zn(NC5H4CO2)2(H2O)2·2H2O. [1] It is a colorless solid.

Contents

Other zinc(II) complexes of picolinic acid have been described. [2] Isostructural with the zinc complex are M(NC5H4CO2)2(H2O)2·2H2O (M = Co and Ni). [3]

Dietary supplement

Zinc picolinate has been used as a dietary zinc supplement. [4] [5] [6]

References

  1. ↑ Lumme, Paavo; Lundgren, Georg; Mark, Wanda; Lundström, Hans; Borch, Gunner; Craig, J. Cymerman (1969). "The Crystal Structure of Zinc Picolinate Tetrahydrate, Zn(C6H4O2N)2(H2O)4". Acta Chemica Scandinavica. 23: 3011–3022. doi:10.3891/acta.chem.scand.23-3011.
  2. ↑ Vargová, Zuzana; Zeleòák, Vladimı́r; Cı́Saøová, Ivana; Györyová, Katarı́na (2004). "Correlation of Thermal and Spectral Properties of Zinc(II) Complexes of Pyridinecarboxylic Acids with Their Crystal Sructures". Thermochimica Acta. 423 (1–2): 149–157. doi:10.1016/j.tca.2004.03.016.
  3. ↑ Tella, Adedibu C.; Oladipo, Adetola C.; Adeyemi, Olalere G.; Oluwafemi, Oluwatobi S.; Oguntoye, Stephen O.; Alimi, Lukman O.; Ajayi, Joseph T.; Degni, Sylvestre K. (2017). "Solid State Synthesis, Spectroscopic and X-Ray Studies of Metal Complexes of 2-Picolinic Acid and Vapochromic Behavior of [Co(Pic)2(H2O)2]·2H2O". Solid State Sciences. 68: 1–9. doi:10.1016/j.solidstatesciences.2017.03.017.
  4. ↑ Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ (June 1994). "Zinc: Health Effects and Research Priorities for the 1990s". Environmental Health Perspectives. 102 (Suppl 2): 5–46. doi:10.1289/ehp.941025. PMC   1567081 . PMID   7925188.
  5. ↑ Sakai F, Yoshida S, Endo S, Tomita H (2002). "Double-Blind, Placebo-Controlled Trial of Zinc Picolinate for Taste Disorders". Acta Oto-Laryngologica. Supplementum. 122 (546): 129–33. doi:10.1080/00016480260046517. PMID   12132610. S2CID   23717414.
  6. ↑ Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC (June 1987). "Comparative Absorption of Zinc Picolinate, Zinc Citrate and Zinc Gluconate in Humans". Agents and Actions. 21 (1–2): 223–8. doi:10.1007/BF01974946. PMID   3630857. S2CID   23567370.
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