Zonadhesin

ZAN
Identifiers
Aliases	ZAN , zonadhesin (gene/pseudogene), zonadhesin
External IDs	OMIM: 602372 MGI: 106656 HomoloGene: 124417 GeneCards: ZAN
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,797,797 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,477,064 bp
RNA expression pattern
	Top expressed in
	right lobe of liver;
	Top expressed in
	entorhinal cortex; ; spermatid; ; left colon; ; embryo; ; seminiferous tubule; ; morula; ; blastocyst; ; jejunum; ; spermatocyte; ; stomach;
	More reference expression data
	n/a
Orthologs
	7455
	22635
	ENSG00000146839
	ENSMUSG00000079173
	Q9Y493
	O88799
NM_003386 ; NM_173055 ; NM_173056 ; NM_173057 ; NM_173058 ;
	NM_173059
	NM_011741
	NP_003377 ; NP_775082
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Zonadhesin is a protein that in humans is encoded by the ZAN gene. ^[5]

Function

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition.

An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015].

Related Research Articles

Dysbindin, short for dystrobrevin-binding protein 1, is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1. Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin. In addition, dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus. In humans, dysbindin is encoded by the DTNBP1 gene.

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Olfactory receptor 51G2 is a protein that in humans is encoded by the OR51G2 gene.

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.

Olfactory receptor 9A2 is a protein that in humans is encoded by the OR9A2 gene.

Olfactory receptor 4F15 is a protein that in humans is encoded by the OR4F15 gene.

Radial spoke head protein 4 homolog A, also known as radial spoke head-like protein 3, is a protein that in humans is encoded by the RSPH4A gene.

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Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.

LY6/PLAUR domain containing 5 is a protein that in humans is encoded by the LYPD5 gene.

FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene.

WD repeat containing planar cell polarity effector is a protein that in humans is encoded by the WDPCP gene.

Pecanex homolog 3 is a protein that in humans is encoded by the PCNX3 gene.

Transmembrane protein 57 is a protein that in humans is encoded by the TMEM57 gene.

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146839 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079173 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zonadhesin (gene/pseudogene)" . Retrieved 2018-06-28.

Gasper J, Swanson WJ (November 2006). "Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution". Am. J. Hum. Genet. 79 (5): 820–30. doi:10.1086/508473. PMC 1698559 . PMID 17033959.
Gnanasekar M, Suleman FG, Ramaswamy K, Caldwell JD (October 2009). "Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening". Int. J. Mol. Med. 24 (4): 421–6. doi: 10.3892/ijmm_00000248 . PMID 19724880.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832 . PMID 19913121.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146839 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079173 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zonadhesin (gene/pseudogene)" . Retrieved 2018-06-28.

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Zonadhesin

Contents

Function

Related Research Articles

References

Further reading