Cerebral angiography

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Cerebral angiography
Cerebral angiography, arteria vertebralis sinister injection.JPG
Cerebral angiogram showing a transverse projection of the vertebro basilar and posterior cerebral circulation.
ICD-9-CM 88.41
MeSH D002533
MedlinePlus 003799

Cerebral angiography is a form of angiography which provides images of blood vessels in and around the brain, thereby allowing detection of abnormalities such as arteriovenous malformations and aneurysms. [1] It was pioneered in 1927 by the Portuguese neurologist Egas Moniz at the University of Lisbon, who also helped develop thorotrast for use in the procedure. [2]

Contents

Typically a catheter is inserted into a large artery (such as the femoral artery) and threaded through the circulatory system to the carotid artery, where a contrast agent is injected. A series of radiographs are taken as the contrast agent spreads through the brain's arterial system, then a second series as it reaches the venous system.

For some applications[ citation needed ] cerebral angiography may yield better images than less invasive methods such as computed tomography angiography and magnetic resonance angiography. In addition, cerebral angiography allows certain treatments to be performed immediately, based on its findings. In recent decades, cerebral angiography has so assumed a therapeutic connotation thanks to the elaboration of endovascular therapeutic techniques. Embolization (a minimally invasive surgical technique) over time has played an increasingly significant role in the multimodal treatment of cerebral MAVs, facilitating subsequent microsurgical or radiosurgical treatment. [3] [4] Another type of treatment possible by angiography (if the images reveal an aneurysm) is the introduction of metal coils through the catheter already in place and maneuvered to the site of aneurysm; over time these coils encourage formation of connective tissue at the site, strengthening the vessel walls. [5] [6]

In some jurisdictions, cerebral angiography is required to confirm brain death.[ citation needed ]

Prior to the advent of modern neuroimaging techniques such as MRI and CT in the mid-1970s, cerebral angiographies were frequently employed as a tool to infer the existence and location of certain kinds of lesions and hematomas by looking for secondary vascular displacement caused by the mass effect related to these medical conditions. This use of angiography as an indirect assessment tool is nowadays obsolete as modern non-invasive diagnostic methods are available to image many kinds of primary intracranial abnormalities directly. [7] It is still widely used however for evaluating various types of vascular pathologies within the skull.

Uses

Cerebral angiography is used for diagnosis but may be followed by treatment procedures in the same setting. [8] Cerebral angiography is used to image various intracranial (within the head) or extracranial (outside the head) diseases. [8]

Intracranial diseases are: non-traumatic subarachnoid haemorrhage, non-traumatic intracerebral haemorrhage, intracranial aneurysm, stroke, cerebral vasospasm, cerebral arteriovenous malformation (for Spetzler-Martin grading and plan for intervention), dural arteriovenous fistula, embolisation of brain tumours such as meningioma, cavernous sinus haemangioma, for Wada test, and to obtain haemodynamics of cerebral blood flow such as cross flow, circulation time, and collateral flow. [8] [9]

Extracranial diseases are: Subclavian steal syndrome, rupture of the carotid artery, carotid artery stenosis, cervical spine trauma, epistaxis (nose bleeding) and plan for embolisation of juvenile nasopharyngeal angiofibroma before operation. [8] [9]

Although computed tomography angiography (CTA) and Magnetic resonance angiography (MRA) has been used widely in evaluation of intracranial disease, cerebral angiography provides higher resolution on the conditions of blood vessel lumens and vasculature. [10] Cerebral angiography is also the standard of detecting intracranial aneurysm and evaluating the feasibility of endovascular coiling. [11] Performing a cerebral angiogram by gaining access through the femoral artery or radial artery is feasible in order to treat cerebral aneurysms with a number of devices [12]

Certain conditions such as contrast allergy, renal insufficiency, and coagulation disorders are contraindicated in this procedure. [8]

Technique

Before the procedure, focused history and neurological examination is performed, available imaging, and blood parameters are reviewed. [9] When reviewing imaging, arch anatomy and variants are evaluated to select suitable catheters to assess the vessels. Complete blood count is reviewed to ensure adequate amount of haemoglobin in subject's body, and to rule out the presence of sepsis. Serum creatinine is assessed to rule out renal dysfunction. Meanwhile, prothrombin time is assessed to rule out coagulopathy. [8] Informed consent regarding the risks of the procedure is taken. [9] Anticoagulants are withheld if possible. [9] Fasting is required 6 hours before the procedure and insulin requirement is reduced by half for those diabetics who are fasting. [9] Bilateral groins (for femoral artery access) and left arm/forearm (for brachial artery/radial artery access) are prepared. Neurological status of the patient before sedation or anesthesia is recorded. [8]

Sedation drug such as intravenous midazolam and painkiller such as fentanyl can be used if the subject is restless or painful. The subject is then lie down on supine position with arm at the sides. Uncooperative subjects may have their forehead tapped to reduce motion. The subject is advised to stay as still as possible especially when fluoroscopy images are taken. The subject is also advised to avoid swallowing when images of neck are taken. These measures are taken to reduce motion artifact in the images. [8]

Right common femoral artery (RFA) is the preferred site of access. If RFA access is not optimal, then brachial artery access is chosen. Either a micropuncture system or an 18G access needle can be used with or without ultrasound guidance. There are four types of catheters that can be used: angled vertebral catheter for usual cases, Judkins right coronary catheter (Terumo) for tourtous vessels, Simmons's catheter and Mani's head hunter catheter (Terumo) for extremely tortous vessels. A 5Fr sheath is also placed within and flushed with heparinised saline to prevent clotting around the sheath. [8] In terms of guidewire, Terumo hydrophilic Glidewire 0.035 inches can be used. [8]

To prevent embolism (either due to blood clot or air embolism, "double flush" and "wet connect" techniques are used. [8] In "double flush" technique, a saline syringe is used to aspirate blood from the catheter. Then, a second heparinised saline syringe is used to flush the catheter. [13] "Wet connect" is the technique that connects syringe to a sheath without air bubbles within. [8]

Digital subtraction angiography is the main technique of imaging the cerebral blood vessels. Catheter should be advanced over the guidewire. Rotating the catheter during advancement is also helpful. Roadmap (superimposing previous image on live fluoroscopic image) is used to advance catheters or guidewires before any vessel bifurcation can help to prevent vessel dissection. [8] After the catheter is in position, guidewire is removed slowly with heparinised saline dripping into the catheter at the same time to prevent air embolism. Prior to contrast injection, backflow of the catheter should be established to ensure there is no wedging, dissection, or intracatheter clotting. During the catheterisation of vertebral artery, extra care should be taken to prevent vessel dissection or vasospasm. Delayed or incomplete contrast washout may indicate vasospasm or dissection. [8]

Radiographic views

Cervical arch angiogram is taken if there is any suspicion of aortic arch narrowing, or any anatomical variants such as bovine arch (brachiocephalic trunk shares a common origin with left common carotid artery). If such abnormality is present, it results it difficulty in cannulation of the main branches of the aortic arch. [8] The catheter of choice to cannulate this area is pigtail catheter with multiple side holes. Contrast injection rate of 20 to 25ml/sec is given with total volume of 40 to 50 ml of contrast. The frame rate of fluoroscopy is 4 to 6 frames per second. [8] The image is taken in with the x-ray tube in left anterior oblique position. [8]

To image the vessels of the neck such as common carotid, internal and external carotid arteries, AP, lateral, and 45 degrees bilateral oblique positions are taken. Contrast injection rate is 3 to 4 ml/sec with total volume of 7 to 9 ml. The frame rate of fluoroscopy is 3 to 4 frames/sec. [8]

To image the anterior cerebral circulation such as internal and external carotid arteries and its branches, AP, Towne's and lateral views are taken. [8] The petrous part of the temporal bone should be superimposed at the mid or lower orbits when taking the AP/Towne's view. Contrast injection rate is 6 to 7 ml/sec with total volume of contrast at 10 ml. [8] [9] The frame rate of fluoroscopy is 2 to 4 frames/sec. [8] Neck extension can help to navigate into tortous cerival part of the internal carotid artery. [14] [15]

At the level of carotid bifurcation, AP and oblique images are taken. At the cavernous (C4) and ophthalmic segments (C6) of the internal carotid artery, Caldwell and lateral views are taken. [8] At the supraclinoid segment (C5-clinoid, C6-ophthalmic, and C7-bifurcation to posterior communicating artery (PCOM) segments), AP view is used to access the terminal branches such as anterior cerebral artery (ACA), middle cerebral artery (MCA) while oblique view (25 to 35 degrees) is used to access the ACA, anterior communicating artery (ACOM), and MCA bifurcations. [8] Lateral view is useful to visualise the PCOM while submentovertical view is useful to project ACOM above the nasal cavity, thus making it easier to access the anatomy of ACOM. Transorbital oblique view is useful to access the MCA anatomy. [8]

The anatomy of external carotid artery is access via AP and lateral views. [8]

To image the posterior circulation, such as vertebral and basilar arteries, AP, Towne's view, lateral projections near the back of the head and upper part of the neck is taken. In this case, petrous bone should be projected at the bottom or below the orbits to visualise the basilar artery and its branches in AP/Towne's view. The rate of injection is 3 to 5 ml/sec, for a total of 8ml. The fluoroscope will be catching images at a rate of 2 to 4 frames per second. [8] Posterior cerebral artery (PCA) can be seen in AP view. [8] The left vertebral artery is easier to cannulate than the right vertebral because of the straightforward anatomy of the left vertebral artery. [16]

Any activation of primary collateral system (ACOM and PCOM arteries) or secondary collateral system (pial-pial and leptomeningeal-dural) in case of occlusion of internal carotid artery should also be documented. [8] [17] Leptomeningeal collaterals or pial collaterals are the small arterial connections that join the terminal branches of ACAs, MCAs, and PCAs on the surface of the brain. [18]

Post-procedural care

Manual compression or percutaneous closure device can be used to stop the bleeding from common femoral artery. Groin haematoma should be monitored during intensive care unit (ICU) monitoring. The puncture should be immobilised (to prevent movement) for 24 hours post puncture. [8] Neurological examination should be performed and new neurological deficit should be documented. Significant neurological changes should be evaluated with MRI scan or a repeat cerebral angiography to rule out acute stroke or vessel dissection. Painkiller should be administered if there is any puncture site pain. [8]

Complications

The most common complication is groin haematoma which occurs in 4% of those affected. Neurologic complications such as transient ischemic attack in 2.5% of the cases. There is also the risk of stroke with permanent neurological defect in 0.1% of the cases and may lead to death in 0.06%. [8] Rarely, 0.3 to 1% of the cases experience cortical blindness from 3 minutes to 12 hours after the procedure. It is a condition where those affected experienced loss of vision with normal pupillary light reflex, and normal extraocular muscles movement. The condition can sometimes be accompanied by headaches, mental state changes, and memory losses. [19]

Some risk factors of complications are if the subject is having subarachnoid haemorrhage, atherosclerotic cerebrovascular disease, frequent transient ischemic attacks, age more than 55 years, and poorly controlled diabetes. Besides, longer procedures, increased in number of catheter exchanges, and the use of larger size of catheters also increases the risk of complications. [8]

History

In 1896, E. Haschek and O.T. Lindenthal in Vienna, Austria, reported angiography of blood vessels by taking a series of X-rays after injecting a mixture of petroleum, quicklime, and mercuric sulfide into the hand of a cadaver. [1]

Cerebral angiography was first described by Egas Moniz, a Portuguese physician and politician, in 1927. He performed this procedure on six patients. Two developed Horner's syndrome due to leaking of contrast material around the carotid artery, one developed temporary aphasia, and another died due to thromboembolism to the anterior circulation of the brain. [20]

Prior to the 1970s the typical technique involved a needle puncture directly into the carotid artery, [21] [22] as depicted in the 1973 horror film The Exorcist , [23] which was replaced by the current method of threading a catheter from a distant artery due to common complications caused by trauma to the artery at the puncture site in the neck (particularly hematomas of the neck, with possible compromission of the airway). [24] [25]

Related Research Articles

<span class="mw-page-title-main">Arteriovenous malformation</span> Vascular anomaly

An arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the capillary system. Usually congenital, this vascular anomaly is widely known because of its occurrence in the central nervous system, but can appear anywhere in the body. The symptoms of AVMs can range from none at all to intense pain or bleeding, and they can lead to other serious medical problems.

<span class="mw-page-title-main">Cerebral arteriovenous malformation</span> Medical condition

A cerebral arteriovenous malformation is an abnormal connection between the arteries and veins in the brain—specifically, an arteriovenous malformation in the cerebrum.

<span class="mw-page-title-main">Intracranial aneurysm</span> Cerebrovascular disorder

An intracranial aneurysm, also known as a cerebral aneurysm, is a cerebrovascular disorder in which weakness in the wall of a cerebral artery or vein causes a localized dilation or ballooning of the blood vessel.

<span class="mw-page-title-main">Aneurysm</span> Bulge in the wall of a blood vessel

An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak spot on a blood vessel wall. Aneurysms may be a result of a hereditary condition or an acquired disease. Aneurysms can also be a nidus for clot formation (thrombosis) and embolization. As an aneurysm increases in size, the risk of rupture, which leads to uncontrolled bleeding, increases. Although they may occur in any blood vessel, particularly lethal examples include aneurysms of the Circle of Willis in the brain, aortic aneurysms affecting the thoracic aorta, and abdominal aortic aneurysms. Aneurysms can arise in the heart itself following a heart attack, including both ventricular and atrial septal aneurysms. There are congenital atrial septal aneurysms, a rare heart defect.

<span class="mw-page-title-main">Angiography</span> Medical imaging technique

Angiography or arteriography is a medical imaging technique used to visualize the inside, or lumen, of blood vessels and organs of the body, with particular interest in the arteries, veins, and the heart chambers. Modern angiography is performed by injecting a radio-opaque contrast agent into the blood vessel and imaging using X-ray based techniques such as fluoroscopy.

<span class="mw-page-title-main">Interventional radiology</span> Medical subspecialty

Interventional radiology (IR) is a medical specialty that performs various minimally-invasive procedures using medical imaging guidance, such as x-ray fluoroscopy, computed tomography, magnetic resonance imaging, or ultrasound. IR performs both diagnostic and therapeutic procedures through very small incisions or body orifices. Diagnostic IR procedures are those intended to help make a diagnosis or guide further medical treatment, and include image-guided biopsy of a tumor or injection of an imaging contrast agent into a hollow structure, such as a blood vessel or a duct. By contrast, therapeutic IR procedures provide direct treatment—they include catheter-based medicine delivery, medical device placement, and angioplasty of narrowed structures.

<span class="mw-page-title-main">Vascular surgery</span> Medical specialty, operative procedures for the treatment of vascular disorders

Vascular surgery is a surgical subspecialty in which vascular diseases involving the arteries, veins, or lymphatic vessels, are managed by medical therapy, minimally-invasive catheter procedures and surgical reconstruction. The specialty evolved from general and cardiovascular surgery where it refined the management of just the vessels, no longer treating the heart or other organs. Modern vascular surgery includes open surgery techniques, endovascular techniques and medical management of vascular diseases - unlike the parent specialities. The vascular surgeon is trained in the diagnosis and management of diseases affecting all parts of the vascular system excluding the coronaries and intracranial vasculature. Vascular surgeons also are called to assist other physicians to carry out surgery near vessels, or to salvage vascular injuries that include hemorrhage control, dissection, occlusion or simply for safe exposure of vascular structures.

<span class="mw-page-title-main">Subarachnoid hemorrhage</span> Bleeding into the subarachnoid space

Subarachnoid hemorrhage (SAH) is bleeding into the subarachnoid space—the area between the arachnoid membrane and the pia mater surrounding the brain. Symptoms may include a severe headache of rapid onset, vomiting, decreased level of consciousness, fever, weakness, numbness, and sometimes seizures. Neck stiffness or neck pain are also relatively common. In about a quarter of people a small bleed with resolving symptoms occurs within a month of a larger bleed.

<span class="mw-page-title-main">Intracranial hemorrhage</span> Hemorrhage, or bleeding, within the skull

Intracranial hemorrhage (ICH), also known as intracranial bleed, is bleeding within the skull. Subtypes are intracerebral bleeds, subarachnoid bleeds, epidural bleeds, and subdural bleeds.

<span class="mw-page-title-main">Embolization</span> Passage and lodging of an embolus within the bloodstream

Embolization refers to the passage and lodging of an embolus within the bloodstream. It may be of natural origin (pathological), in which sense it is also called embolism, for example a pulmonary embolism; or it may be artificially induced (therapeutic), as a hemostatic treatment for bleeding or as a treatment for some types of cancer by deliberately blocking blood vessels to starve the tumor cells.

<span class="mw-page-title-main">Digital subtraction angiography</span> Method for delineating blood vessels using contrast medium

Digital subtraction angiography (DSA) is a fluoroscopy technique used in interventional radiology to clearly visualize blood vessels in a bony or dense soft tissue environment. Images are produced using contrast medium by subtracting a "pre-contrast image" or mask from subsequent images, once the contrast medium has been introduced into a structure. Hence the term "digital subtraction angiography. Subtraction angiography was first described in 1935 and in English sources in 1962 as a manual technique. Digital technology made DSA practical starting in the 1970s.

<span class="mw-page-title-main">Dural arteriovenous fistula</span> Medical condition

A dural arteriovenous fistula (DAVF) or malformation is an abnormal direct connection (fistula) between a meningeal artery and a meningeal vein or dural venous sinus.

<span class="mw-page-title-main">Vertebral artery dissection</span> Tear of the inner lining of the vertebral artery

Vertebral artery dissection (VAD) is a flap-like tear of the inner lining of the vertebral artery, which is located in the neck and supplies blood to the brain. After the tear, blood enters the arterial wall and forms a blood clot, thickening the artery wall and often impeding blood flow. The symptoms of vertebral artery dissection include head and neck pain and intermittent or permanent stroke symptoms such as difficulty speaking, impaired coordination, and visual loss. It is usually diagnosed with a contrast-enhanced CT or MRI scan.

<span class="mw-page-title-main">Carotid stenting</span>

Carotid artery stenting is an endovascular procedure where a stent is deployed within the lumen of the carotid artery to treat narrowing of the carotid artery and decrease the risk of stroke. It is used to treat narrowing of the carotid artery in high-risk patients, when carotid endarterectomy is considered too risky.

<span class="mw-page-title-main">Computed tomography angiography</span> Medical investigation technique

Computed tomography angiography is a computed tomography technique used for angiography—the visualization of arteries and veins—throughout the human body. Using contrast injected into the blood vessels, images are created to look for blockages, aneurysms, dissections, and stenosis. CTA can be used to visualize the vessels of the heart, the aorta and other large blood vessels, the lungs, the kidneys, the head and neck, and the arms and legs. CTA can also be used to localise arterial or venous bleed of the gastrointestinal system.

<span class="mw-page-title-main">Leptomeningeal collateral circulation</span>

The leptomeningeal collateral circulation is a network of small blood vessels in the brain that connects branches of the middle, anterior and posterior cerebral arteries, with variation in its precise anatomy between individuals. During a stroke, leptomeningeal collateral vessels allow limited blood flow when other, larger blood vessels provide inadequate blood supply to a part of the brain.

<span class="mw-page-title-main">Endovascular coiling</span>

Endovascular coiling is an endovascular treatment for intracranial aneurysms and bleeding throughout the body. The procedure reduces blood circulation to the aneurysm through the use of microsurgical detachable platinum wires, with the clinician inserting one or more into the aneurysm until it is determined that blood flow is no longer occurring within the space. It is one of two main treatments for cerebral aneurysms, the other being surgical clipping. Clipping is an alternative to stenting for bleeding.

Interventional neuroradiology (INR) also known as neurointerventional surgery (NIS), endovascular therapy (EVT), endovascular neurosurgery, and interventional neurology is a medical subspecialty of neurosurgery, neuroradiology, intervention radiology and neurology specializing in minimally invasive image-based technologies and procedures used in diagnosis and treatment of diseases of the head, neck, and spine.

<span class="mw-page-title-main">Flow diverter</span>

A flow diverter is an endovascular prosthesis used to treat intracranial aneurysms. It is placed in the aneurysm's parent artery, covering the neck, in order to divert blood flow and determine a progressive thrombosis of the sac. Flow diverting stents consist of structural Cobalt-chrome or Nitinol alloy wires and often a set of radiopaque wires woven together in a flexible braid.

Alexander Coon is an American neurosurgeon who is the Director of Endovascular and Cerebrovascular Neurosurgery at the Carondelet Neurological Institute of St. Joseph's and St. Mary's Hospitals in Tucson, Arizona. He was previously the Director of Endovascular Neurosurgery at the Johns Hopkins Hospital and an assistant professor of neurosurgery, Neurology, and Radiology at the Johns Hopkins Hospital. He is known for his work in cerebrovascular and endovascular neurosurgery and his research in neuroendovascular devices and clinical outcomes in the treatment of cerebral aneurysms, subarachnoid hemorrhage, and AVMs.

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