| Doubles | |
|---|---|
| 2010 Comerica Bank Challenger | |
| Champions |  Carsten Ball Chris Guccione |
| Runners-up | Adam Feeney Greg Jones |
| Final score | 6–1, 6–3 |
Carsten Ball and Chris Guccione are the defending champions. They successfully defended their title, defeating Adam Feeney and Greg Jones in the final 6–1, 6–3.
Sanchai Ratiwatana / Sonchat Ratiwatana (semifinals) Carsten Ball / Chris Guccione (champions)
Treat Conrad Huey / 
Dominic Inglot (first round)
Pierre-Ludovic Duclos / 
Artem Sitak (quarterfinals)| First round | Quarterfinals | Semifinals | Finals | ||||||||||||||||||||||||
| 1 | Sa Ratiwatana So Ratiwatana | 6 | 6 | ||||||||||||||||||||||||
| WC |  M Fawcett  J Kepler | 3 | 3 | 1 | Sa Ratiwatana So Ratiwatana | 7 | 5 | [10] | |||||||||||||||||||
| WC | C Buchanan B Klahn | 6 | 6 | WC | C Buchanan B Klahn | 63 | 7 | [8] | |||||||||||||||||||
 K Beck  S Bubka | 4 | 2 | 1 | Sa Ratiwatana So Ratiwatana | 2 | 3 | |||||||||||||||||||||
| 4 | P-L Duclos A Sitak | 6 | 6 | A Feeney G Jones | 6 | 6 | |||||||||||||||||||||
| A Bogdanovic T Smyczek | 3 | 4 | 4 | P-L Duclos A Sitak | 4 | 5 | |||||||||||||||||||||
| A Feeney G Jones | 6 | 6 | A Feeney G Jones | 6 | 7 | ||||||||||||||||||||||
| R Klaasen I van der Merwe | 3 | 4 | A Feeney G Jones | 1 | 3 | ||||||||||||||||||||||
 I Bozoljac K Kim | 6 | 3 | [6] | 2 | C Ball C Guccione | 6 | 6 | ||||||||||||||||||||
| WC | D Britton D Young | 4 | 6 | [10] | WC | D Britton D Young | 4 | 7 | [11] | ||||||||||||||||||
| Q | JP Fruttero B Klein | 2 | 6 | [10] | Q | JP Fruttero B Klein | 6 | 5 | [9] | ||||||||||||||||||
| 3 | TC Huey D Inglot | 6 | 3 | [4] | WC | D Britton D Young | 2 | 4 | |||||||||||||||||||
| P Polansky M Raonic | 7 | 6 | 2 | C Ball C Guccione | 6 | 6 | |||||||||||||||||||||
 F Nielsen J Sirianni | 610 | 4 | P Polansky M Raonic | 64 | 2 | ||||||||||||||||||||||
| A Kuznetsov R Ram | 3 | 1 | 2 | C Ball C Guccione | 7 | 6 | |||||||||||||||||||||
| 2 | C Ball C Guccione | 6 | 6 | ||||||||||||||||||||||||
Scott Lipsky and David Martin won the doubles competition in January 2009 and were the defending champions, but chose not to participate.
Harsh Mankad and Frederik Nielsen defeated 6–4, 6–4 Carsten Ball and Travis Rettenmaier in the final.
Jordan Kerr and Rajeev Ram were the defending champions, but chose not to compete with each other.
Kerr chose to compete with Ross Hutchins, but they got out in the first round to Jonathan Erlich and Scott Lipsky.
Ram chose to compete with Jean-Julien Rojer. However, they lost in the first round to Marc Gicquel and Santiago Ventura.
Unseeded Carsten Ball and Chris Guccione won in the final 6–3, 6–4, against Santiago González and Travis Rettenmaier.
Nicholas Monroe and Michael Yani were the defending champions, but they chose to not participate together this year.
Monroe partnered up with Brian Battistone and they were eliminated by Carsten Ball and Travis Rettenmaier in the semifinal.
Yani played with Todd Widom. They withdrew before match against Pierre-Ludovic Duclos and Alex Kuznetsov in the quarterfinal, due to Widom's injury.
Ball and Rettenmaier became the new winners, after won in the final, against Adam Feeney and Nathan Healey 6–3, 6–4.
Noam Okun and Amir Weintraub were the defending champions, but they didn't start this year.
Carsten Ball and Chris Guccione won the tournament, after defeating Sanchai Ratiwatana and Sonchat Ratiwatana in the final 6–3, 6–2.
Paul Capdeville, the defending champion, defeated Kevin Anderson 7–6(7), 7–6(11) in the final.
Lester Cook and David Martin were the defending champions, but chose to not compete this year.
Rik de Voest and Izak van der Merwe won in the final 4–6, 6–4, [10–7], against Nicholas Monroe and Donald Young.
Bernard Tomic was the defending champion. He reached the semifinals, where he lost 3–6, 7–6(7–3), 6–7(5–7) to Chris Guccione.
Guccione withdrew before his match against Flavio Cipolla in the final. As a result, Cipolla won the tournament.
Marinko Matosevic, the defending champion, didn't participate this year.
Carsten Ball and Chris Guccione successfully defended their 2010 title, defeating John Paul Fruttero and Raven Klaasen in the final, 7–6(7–5), 6–4.
Carsten Ball was the defending champion but lost in the second round to Blake Strode.
Rik de Voest and Izak van der Merwe were the defending champions, but only van der Merwe decided to participate. He played alongside Treat Conrad Huey, but Carsten Ball and Chris Guccione eliminated them already in the first round. Ball and Guccione went on to win the title by defeating Nicholas Monroe and Jack Sock 7–6(7–3), 1–6, [10–5] in the final.
Somdev Devvarman was the defending champion, but he decided not to start this year.
Harel Levy defeated 6–4, 4–6, 6–2 Alex Kuznetsov in the final.
Rik de Voest and Izak van der Merwe were the defending champions but de Voest decided not to participate.
van der Merwe played alongside Michael Yani, losing in the semifinals.
Carsten Ball and Bobby Reynolds won the title, defeating Travis Parrott and Simon Stadler 7–6(9–7), 6–4 in the final.
Carsten Ball and Chris Guccione were the defending champions; however, Ball chose not to compete. Guccione competed with Frank Moser.
Rik de Voest and John Peers won the title, defeating Guccione and Moser 6–7(5–7), 6–1, [10–4] in the final.
Carsten Ball and Chris Guccione were the defending champions but Ball decided not to participate.
Guccione played alongside Samuel Groth.
Tennys Sandgren and Rhyne Williams won the title against Devin Britton and Austin Krajicek by defeating them 4–6, 6–4, [12–10] in the final.
Carsten Ball and Chris Guccione were the defending champions but Ball decided not to participate.
Guccione played alongside Rik de Voest and won the final against Jordan Kerr and Andreas Siljeström 6–1, 6–4.
Sanchai Ratiwatana and Sonchat Ratiwatana were the defending champions but decided not to participate.
Purav Raja and Divij Sharan defeated Chris Guccione and Matt Reid 6–4, 7–5 in the final, to win the title.
Carsten Ball and Chris Guccione won the first edition of the tournament 6–3, 3–6, [11–9] in the final against Jordan Kerr and John-Patrick Smith.
Sanchai Ratiwatana and Sonchat Ratiwatana were the defending champions, but they lost to Victor Baluda and Dino Marcan in the first round.
Baluda and Marcan defeated Samuel Groth and John-Patrick Smith 6–7(5–7), 6–4, [10–7] in the final to win the title.
Samuel Groth and Chris Guccione were the defending champions, but Guccione did not participate. Groth partnered with Ryan Harrison, but they withdrew in the semifinals.