| 2010 Comerica Bank Challenger | |
|---|---|
| Date | July 12 – July 18 |
| Edition | 23rd |
| Location | Aptos, United States |
| Champions | |
| Singles | |
 Marinko Matosevic | |
| Doubles | |
| Carsten Ball / Chris Guccione | |
The 2010 Comerica Bank Challenger was a professional tennis tournament played on hard court. This was the twenty-third edition of the tournament which is part of the 2010 ATP Challenger Tour. It took place in Aptos, United States between 12 July and 18 July 2010.
| Nationality | Player | Ranking* | Seeding |
|---|---|---|---|
 USA | Rajeev Ram | 98 | 1 |
 IND | Somdev Devvarman | 107 | 2 |
| USA | Donald Young | 111 | 3 |
| AUS | Carsten Ball | 131 | 4 |
 SRB | Ilija Bozoljac | 137 | 5 |
| USA | Kevin Kim | 147 | 6 |
 GBR | Alex Bogdanovic | 172 | 7 |
| USA | Tim Smyczek | 180 | 8 |
The following players received wildcards into the singles main draw:
Devin Britton Chase Buchanan Daniel Kosakowski Bradley Klahn The following players received a place as a special entrant:
The following players received entry from the qualifying draw:
Karol Beck Dayne Kelly Brydan Klein 
Artem Sitak Marinko Matosevic def. Donald Young, 6–4, 6–2
Carsten Ball / Chris Guccione def. Adam Feeney / Greg Jones, 6–1, 6–3
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