| 2010 Samarkand Challenger | |
|---|---|
| Date | August 9 – August 14 |
| Edition | 14th |
| Location | Samarkand, Uzbekistan |
| Champions | |
| Singles | |
 | |
| Doubles | |
 | |
The 2010 Samarkand Challenger was a professional tennis tournament played on outdoor red clay courts. It was the fourteenth edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Samarkand, Uzbekistan between 9 and 14 August 2010.
| Nationality | Player | Ranking* | Seeding |
|---|---|---|---|
 | Blaž Kavčič | 88 | 1 |
 | Óscar Hernández | 158 | 2 |
 | Andrey Kuznetsov | 167 | 3 |
 | Guillaume Rufin | 174 | 4 |
| Evgeny Kirillov | 205 | 5 |
| Andrej Martin | 288 | 6 |
| Marek Semjan | 297 | 7 |
| Andis Juška | 312 | 8 |
The following players received wildcards into the singles main draw:
The following players received a Special Exempt into the main draw:
The following players received entry from the qualifying draw:
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