Qualified teams
The winners and runners-up of each of the two groups in the group stage qualified for the knockout stage.
| Group | Winners | Runners-up |
|---|---|---|
| A |  Wydad AC |  ZESCO United |
| B |  Mamelodi Sundowns |  Zamalek |
The 2016 CAF Champions League knockout stage was played from 16 September to 23 October 2016. [1] A total of four teams competed in the knockout stage to decide the champions of the 2016 CAF Champions League. [2]
The winners and runners-up of each of the two groups in the group stage qualified for the knockout stage.
| Group | Winners | Runners-up |
|---|---|---|
| A | Wydad AC | ZESCO United |
| B | Mamelodi Sundowns | Zamalek |
In the knockout stage, the four teams played a single-elimination tournament. Each tie was played on a home-and-away two-legged basis. If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III. 26 & 27). [2]
The schedule of each round was as follows. [1]
| Round | First leg | Second leg |
|---|---|---|
| Semi-finals | 16–18 September 2016 | 23–25 September 2016 |
| Final | 14–16 October 2016 | 21–23 October 2016 |
The bracket of the knockout stage was determined as follows: [2]
| Semi-finals | Final | ||||||||||||
| 1 | ZESCO United | 2 | 0 | 2 | |||||||||
| 4 | Mamelodi Sundowns | 1 | 2 | 3 | |||||||||
| Mamelodi Sundowns | 3 | 0 | 3 | ||||||||||
| Zamalek | 0 | 1 | 1 | ||||||||||
| 3 | Zamalek | 4 | 2 | 6 | |||||||||
| 2 | Wydad AC | 0 | 5 | 5 | |||||||||
In the semi-finals, the group A winners played the group B runners-up, and the group B winners played the group A runners-up, with the group winners hosting the second leg.
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Zamalek | 6–5 | Wydad AC | 4–0 | 2–5 |
| ZESCO United | 2–3 | Mamelodi Sundowns | 2–1 | 0–2 |
| Zamalek | 4–0 | Wydad AC |
|---|---|---|
Shikabala  4'Hefny 18'Morsy 49'Fathi 73' (pen.) | Report |
| Wydad AC | 5–2 | Zamalek |
|---|---|---|
| Jebor 13', 45' Haddad 18'Ondama 56', 63' (pen.) | Report | Morsy 35' Ohawuchi 82' |
Zamalek won 6–5 on aggregate.
| ZESCO United | 2–1 | Mamelodi Sundowns |
|---|---|---|
| Mwanza 54', 56' | Report | Billiat 86' |
| Mamelodi Sundowns | 2–0 | ZESCO United |
|---|---|---|
| Laffor 5' Tau 64' | Report |
Mamelodi Sundowns won 3–2 on aggregate.
In the final, the two semi-final winners played each other, with the order of legs decided by an additional draw held after the group stage draw. [3]
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Mamelodi Sundowns | 3–1 | Zamalek | 3–0 | 0–1 |
| Zamalek | 1–0 | Mamelodi Sundowns |
|---|---|---|
| Ohawuchi 63' | Report |
Mamelodi Sundowns won 3–1 on aggregate.