Vasek Pospisil and Jack Sock were the defending champions, but lost in the third round to Jamie Murray and John Peers. Jean-Julien Rojer and Horia Tecău won the title by defeating Murray and Peers in the final by a score of 7–6(7–5), 6–4, 6–4.
Bob and Mike Bryan were the defending champions, but lost to Steve Johnson and Sam Querrey in the first round, making their earliest exit in Grand Slam since 2000 Wimbledon Championships, ending their record streak of winning at least one Grand Slam title every year for the previous 10 years.
Simone Bolelli and Fabio Fognini were the defending champions, but lost in the second round to Adrian Mannarino and Lucas Pouille.
Bob and Mike Bryan were the two-time defending champions, but lost in the semifinals to Pierre-Hugues Herbert and Nicolas Mahut.
Ivan Dodig and Marcelo Melo were the defending champions, but lost in the semifinals to Feliciano López and Marc López.
Bob and Mike Bryan were the defending champions, but lost in the quarterfinals to Florin Mergea and Horia Tecău.
Daniel Nestor and Édouard Roger-Vasselin were the defending champions, but chose not to compete together. Nestor played alongside Vasek Pospisil, but lost in the semifinals to Ivan Dodig and Marcelo Melo. Roger-Vasselin teamed up with Julien Benneteau, but lost in the first round to Milos Raonic and Nenad Zimonjić.
Raven Klaasen and Marcelo Melo were the defending champions, but decided not to participate together. Klaasen teamed up with Rajeev Ram, but they lost to Jo-Wilfried Tsonga and Nenad Zimonjić in the second round. Melo played alongside Łukasz Kubot, but they lost to Pablo Cuevas and Marcel Granollers in the second round.
Ivan Dodig and Marcelo Melo were the defending champions, but Dodig chose not to participate this year. Melo played alongside Vasek Pospisil, but lost to John Peers and Henri Kontinen in the semifinals.
Pierre-Hugues Herbert and Nicolas Mahut were the defending champions, but lost in the second round to Novak Djokovic and Viktor Troicki.
Pierre-Hugues Herbert and Nicolas Mahut were the defending champions, but withdrew before their second round match due to Herbert's leg injury.
Jean-Julien Rojer and Horia Tecău were the defending champions, but lost in the first round to Nick Kyrgios and Jack Sock.
Bob and Mike Bryan were the defending champions, but lost in the semifinals to Pierre-Hugues Herbert and Nicolas Mahut.
Ivan Dodig and Marcelo Melo were the defending champions, but chose not to participate together. Melo played alongside Łukasz Kubot, but lost in the second round to Fabrice Martin and Édouard Roger-Vasselin. Dodig teamed up with Rohan Bopanna, but lost in the final to Pierre-Hugues Herbert and Nicolas Mahut, 4–6, 6–3, [6–10].
Ivan Dodig and Marcelo Melo were the defending champions, but chose not to participate together. Dodig teamed up with Rohan Bopanna, but lost in the quarterfinals to Melo who partnered Łukasz Kubot. Kubot and Melo lost in the semifinals to Jamie Murray and Bruno Soares.
John Isner and Jack Sock were the defending champions but withdrew from their first round match.
Henri Kontinen and John Peers were the defending champions, but lost in the quarterfinals to Ivan Dodig and Marcel Granollers.
Łukasz Kubot and Marcelo Melo were the defending champions, but they were defeated in the second round by Jonathan Erlich and Marcin Matkowski.
Bob and Mike Bryan were the defending champions, but Bob was unable to compete due to an injury. Mike played alongside James Cerretani, but lost in the first round to Scott Clayton and Joe Salisbury.
Juan Sebastián Cabal and Robert Farah won their second consecutive Grand Slam men's doubles title, defeating Marcel Granollers and Horacio Zeballos in the final, 6–4, 7–5 to win the men's doubles tennis title at the 2019 US Open. Cabal and Farah retained the ATP no. 1 doubles ranking. Mike Bryan, Łukasz Kubot and Nicolas Mahut were also in contention for the top ranking at the start of the tournament.
John Isner 
