| Singles | |
|---|---|
| 2018 Los Cabos Open | |
| Champion |  Fabio Fognini |
| Runner-up |  Juan Martín del Potro |
| Final score | 6–4, 6–2 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Sam Querrey was the defending champion, [1] but lost in the second round to Egor Gerasimov.
Fabio Fognini won the title, defeating Juan Martín del Potro in the final, 6–4, 6–2.
The top four seeds received a bye into the second round.
Juan Martín del Potro (final) Fabio Fognini (champion)
Damir Džumhur (semifinals)
Adrian Mannarino (quarterfinals)
Sam Querrey (second round) Ryan Harrison (withdrew) Taylor Fritz (second round)
Feliciano López (second round)| Semifinals | Final | ||||||||||||
| 1 | Juan Martín del Potro | 6 | 78 | ||||||||||
| 3 | Damir Džumhur | 3 | 66 | ||||||||||
| 1 | Juan Martín del Potro | 4 | 2 | ||||||||||
| 2 | Fabio Fognini | 6 | 6 | ||||||||||
 Cameron Norrie | 4 | 2 | |||||||||||
| 2 | Fabio Fognini | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | JM del Potro | 7 | 6 | ||||||||||||||||||||||||
| Q | M Giron | 6 | 7 | Q | M Giron | 5 | 3 | ||||||||||||||||||||
 M Arévalo | 2 | 5 | 1 | JM del Potro | 6 | 6 | |||||||||||||||||||||
 B Tomic | 4 | 3 | PR |  E Gerasimov | 1 | 1 | |||||||||||||||||||||
| PR | E Gerasimov | 6 | 6 | PR | E Gerasimov | 7 | 5 | 78 | |||||||||||||||||||
| WC |  L Gómez | 2 | 3 | 5 | S Querrey | 5 | 7 | 66 | |||||||||||||||||||
| 5 | S Querrey | 6 | 6 | 1 | JM del Potro | 6 | 78 | ||||||||||||||||||||
| 3 | D Džumhur | 3 | 66 | ||||||||||||||||||||||||
| 3 | D Džumhur | 77 | 77 | ||||||||||||||||||||||||
| T Fabbiano | 5 | 6 | 7 | T Fabbiano | 60 | 65 | |||||||||||||||||||||
| Q |  T Garanganga | 7 | 2 | 5 | 3 | D Džumhur | 6 | 6 | |||||||||||||||||||
| WC | E Escobedo | 3 | 6 | 1 | M Mmoh | 2 | 3 | ||||||||||||||||||||
| M Mmoh | 6 | 4 | 6 | M Mmoh | 77 | 77 | |||||||||||||||||||||
 P Polansky | 6 | 3 | 6 | P Polansky | 61 | 62 | |||||||||||||||||||||
| LL |  DE Galán | 4 | 6 | 2 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | F López | 77 | 6 | ||||||||||||||||||||||||
| Q |  M Safwat | 63 | 4 | 8 | F López | 3 | 3 | ||||||||||||||||||||
| C Norrie | 6 | 6 | C Norrie | 6 | 6 | ||||||||||||||||||||||
| Q |  P Gunneswaran | 2 | 2 | C Norrie | 6 | 6 | |||||||||||||||||||||
 I Karlović | 4 | 3 | 4 | A Mannarino | 4 | 4 | |||||||||||||||||||||
 E Ymer | 6 | 6 | E Ymer | 0 | 2 | ||||||||||||||||||||||
| 4 | A Mannarino | 6 | 6 | ||||||||||||||||||||||||
| C Norrie | 4 | 2 | |||||||||||||||||||||||||
| 7 | T Fritz | 78 | 77 | 2 | F Fognini | 6 | 6 | ||||||||||||||||||||
| WC | T Kokkinakis | 66 | 65 | 7 | T Fritz | 63 | 1 | ||||||||||||||||||||
 G Elias | 4 | 3 | PR |  Y Nishioka | 77 | 6 | |||||||||||||||||||||
| PR | Y Nishioka | 6 | 6 | PR | Y Nishioka | 2 | 2 | ||||||||||||||||||||
 G Müller | 4 | 4 | 2 | F Fognini | 6 | 6 | |||||||||||||||||||||
| Q Halys | 6 | 6 | Q Halys | 6 | 4 | 0 | |||||||||||||||||||||
| 2 | F Fognini | 2 | 6 | 6 | |||||||||||||||||||||||
Daniel Elahi Galán (qualifying competition, lucky loser) Mohamed Safwat (qualified) Prajnesh Gunneswaran (qualified) Evan King (first round) Bradley Mousley (first round) Evan Song (qualifying competition) Aleksandar Vukic (qualifying competition) Austin Krajicek (first round)| First round | Qualifying competition | ||||||||||||
| 1 | Daniel Elahi Galán | 2 | 5 | ||||||||||
| Marcos Giron | 6 | 7 | |||||||||||
| Marcos Giron | 6 | 6 | |||||||||||
| 5 | Bradley Mousley | 4 | 3 | ||||||||||
| First round | Qualifying competition | ||||||||||||
| 2 | Mohamed Safwat | 6 | 6 | ||||||||||
| WC | Alan Magadán | 2 | 0 | ||||||||||
| 2 | Mohamed Safwat | 2 | 77 | 6 | |||||||||
| 7 | Aleksandar Vukic | 6 | 62 | 4 | |||||||||
| Jacob Grills | 6 | 2 | 3 | ||||||||||
| 7 | Aleksandar Vukic | 3 | 6 | 6 | |||||||||
| First round | Qualifying competition | ||||||||||||
| 3 | Prajnesh Gunneswaran | 6 | 6 | ||||||||||
| Miguel Ángel Reyes-Varela | 4 | 0 | |||||||||||
| 3 | Prajnesh Gunneswaran | 6 | 6 | ||||||||||
| 6 | Evan Song | 3 | 1 | ||||||||||
| Tigre Hank | 4 | 2 | |||||||||||
| 6 | Evan Song | 6 | 6 | ||||||||||
| First round | Qualifying competition | ||||||||||||
| 4 | Evan King | 62 | 6 | 65 | |||||||||
| Takanyi Garanganga | 77 | 4 | 77 | ||||||||||
| Takanyi Garanganga | 6 | 0 | 79 | ||||||||||
| WC | Luis Patiño | 2 | 6 | 67 | |||||||||
| WC | Luis Patiño | 6 | 6 | ||||||||||
| 8 | Austin Krajicek | 4 | 4 | ||||||||||
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