| Doubles | |
|---|---|
| 2018 U.S. Men's Clay Court Championships | |
| Champions |  Max Mirnyi  Philipp Oswald |
| Runners-up |  Andre Begemann  Antonio Šančić |
| Final score | 6–7(2–7), 6–4, [11–9] |
Julio Peralta and Horacio Zeballos were the defending champions, but lost in the first round to Max Mirnyi and Philipp Oswald.
Mirnyi and Oswald went on to win the title, defeating Andre Begemann and Antonio Šančić in the final, 6–7(2–7), 6–4, [11–9].
Bob Bryan / Mike Bryan (semifinals) Ryan Harrison / 
Ben McLachlan (first round)
Julio Peralta / 
Horacio Zeballos (first round)
Santiago González / Donald Young (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | B Bryan M Bryan | 6 | 6 | ||||||||||||||||||||||||
| PR | T Daniel Y Nishioka | 1 | 1 | 1 | B Bryan M Bryan | 4 | 6 | [10] | |||||||||||||||||||
 K Skupski N Skupski | 6 | 77 | K Skupski N Skupski | 6 | 3 | [6] | |||||||||||||||||||||
 F Martin  P Raja | 1 | 60 | 1 | B Bryan M Bryan | 4 | 6 | [6] | ||||||||||||||||||||
| 3 | J Peralta H Zeballos | 3 | 60 | M Mirnyi P Oswald | 6 | 2 | [10] | ||||||||||||||||||||
| M Mirnyi P Oswald | 6 | 77 | M Mirnyi P Oswald | 64 | 77 | [11] | |||||||||||||||||||||
| J Sock J Withrow | 6 | 4 | [6] | S Lipsky T Sandgren | 77 | 61 | [9] | ||||||||||||||||||||
| S Lipsky T Sandgren | 2 | 6 | [10] | M Mirnyi P Oswald | 62 | 6 | [11] | ||||||||||||||||||||
| A Begemann A Šančić | 6 | 6 | A Begemann A Šančić | 77 | 4 | [9] | |||||||||||||||||||||
N Monroe  J-P Smith | 3 | 4 | A Begemann A Šančić | 77 | 6 | ||||||||||||||||||||||
| G Durán A Molteni | 3 | 6 | [1] | 4 | S González D Young | 64 | 2 | ||||||||||||||||||||
| 4 | S González D Young | 6 | 4 | [10] | A Begemann A Šančić | 6 | 3 | [10] | |||||||||||||||||||
| WC | I Karlović  D Nestor | 78 | 6 | WC | D Brown F Tiafoe | 3 | 6 | [7] | |||||||||||||||||||
| N Kyrgios M Reid | 66 | 4 | WC | I Karlović D Nestor | 65 | 3 | |||||||||||||||||||||
| WC | D Brown F Tiafoe | 6 | 77 | WC | D Brown F Tiafoe | 77 | 6 | ||||||||||||||||||||
| 2 | R Harrison B McLachlan | 2 | 64 | ||||||||||||||||||||||||
Julio Leonardo Peralta Martínez is a professional tennis player from Chile. Peralta has found success in the late stage of his career, reaching no. 29 in the ATP rankings in doubles. He captured six doubles titles at ATP World Tour and one singles challenger title. He went on hiatus from 2005 to 2007, from 2009 to 2011, from 2012 to 2014 and from 2018 to 2022.
Juan Sebastián Cabal and Robert Farah were the defending champions, but chose to compete in Acapulco instead.
Aliaksandr Bury and Denis Istomin were the defending champions, but Bury chose to compete in Kitzbühel instead. Istomin played alongside Dominic Inglot, but lost in the quarterfinals to Purav Raja and Divij Sharan.
Guillermo Durán and Horacio Zeballos were the defending champions but chose to participate with different partners. Durán played alongside Andrés Molteni while Zeballos played with Julio Peralta. Durán lost in the first round to Andrea Arnaboldi and Ramkumar Ramanathan.
Julio Peralta and Horacio Zeballos were the defending champions and successfully defended their title, defeating Sergio Galdós and Fernando Romboli 7–6(7–5), 7–6(7–1) in the final.
Pablo Carreño Busta and Guillermo Durán were the defending champions, but Carreño Busta decided not to participate this year. Durán played alongside Andrés Molteni, but lost in the quarterfinals to Víctor Estrella Burgos and Renzo Olivo.
Julio Peralta and Horacio Zeballos were the defending champions, but lost in the quarterfinals to Facundo Bagnis and Guillermo Durán.
Bob and Mike Bryan were the defending champions, but lost in the semifinals to Julio Peralta and Horacio Zeballos.
Henri Kontinen and John Peers were the defending champions, but chose not to participate this year.
Pierre-Hugues Herbert and Nicolas Mahut were the defending champions, but lost in the second round to Jay Clarke and Marcus Willis.
Julio Peralta and Horacio Zeballos were the defending champions, but chose to compete in Hamburg instead.
Marcin Matkowski and Aisam-ul-Haq Qureshi were the defending champions, but lost in the quarterfinals to Raven Klaasen and Michael Venus.
Juan Sebastián Cabal and Robert Farah were the two-time defending champions, but lost in the final to Andrés Molteni and Horacio Zeballos, 3–6, 7–5, [3–10].
Julian Knowle and Philipp Petzschner were the defending champions, but Knowle chose not to participate this year. Petzschner played alongside Jürgen Melzer, but lost in the semifinals to Julio Peralta and Horacio Zeballos.
Pablo Cuevas and Guillermo Durán were the defending champions, but chose not to participate this year.
Roman Jebavý and Matwé Middelkoop were the defending champions, but lost in the final to Matteo Berrettini and Fabio Fognini, 6–7(6–8), 6–7(4–7).
Max Mirnyi and Philipp Oswald were the defending champions, but lost in the final to Austin Krajicek and Rajeev Ram, 6–7(4–7), 4–6.
Julio Peralta and Horacio Zeballos were the defending champions, but Peralta chose not to participate this year. Zeballos played alongside Federico Delbonis, but lost to Sander Gillé and Joran Vliegen in the final, 7–6(7–5), 5–7, [5–10].
Julio Peralta and Horacio Zeballos were the defending champions, but Peralta chose not to participate this year. Zeballos played alongside Leonardo Mayer, but lost in the first round to Pablo Cuevas and Nicolás Jarry.
Defending champions Nikola Mektić and Mate Pavić defeated John Isner and Diego Schwartzman in the final, 6–2, 6–7(6–8), [12–10] to win the men's doubles tennis title at the 2022 Italian Open. The pair saved a championship point en route to their tenth career title as a team.