| Doubles | |
|---|---|
| 2021 Monterrey Open | |
| Champions |  Caroline Dolehide Asia Muhammad |
| Runners-up |  Heather Watson  Zheng Saisai |
| Score | 6–2, 6–3 |
| Draw | 16 |
| Seeds | 4 |
Kateryna Bondarenko and Sharon Fichman were the defending champions [1] but chose not to participate.
Caroline Dolehide and Asia Muhammad won the title, defeating Heather Watson and Zheng Saisai in the final, 6–2, 6–3. [2]
Desirae Krawczyk / 
Giuliana Olmos (quarterfinals) Caroline Dolehide / Asia Muhammad (champions)
Arantxa Rus / 
Tamara Zidanšek (first round)
Lara Arruabarrena / 
Ellen Perez (semifinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | D Krawczyk G Olmos | 6 | 6 | ||||||||||||||||||||||||
M Sanchez  F Stollár | 3 | 2 | 1 | D Krawczyk G Olmos | 6 | 3 | [5] | ||||||||||||||||||||
 V Gracheva K Juvan | 6 | 1 | [7] | H Watson S Zheng | 1 | 6 | [10] | ||||||||||||||||||||
| H Watson S Zheng | 2 | 6 | [10] | H Watson S Zheng | w/o | ||||||||||||||||||||||
| 3 | A Rus T Zidanšek | 2 | 2 | A Blinkova  N Podoroska | |||||||||||||||||||||||
 G Minnen I Neel | 6 | 6 | G Minnen I Neel | 7 | 4r | ||||||||||||||||||||||
D Jakupović  A Raina | 1 | 4 | A Blinkova N Podoroska | 5 | 1 | ||||||||||||||||||||||
| A Blinkova N Podoroska | 6 | 6 | H Watson S Zheng | 2 | 3 | ||||||||||||||||||||||
 P Kania-Choduń K Piter | 7 | 7 | 2 | C Dolehide A Muhammad | 6 | 6 | |||||||||||||||||||||
 N Hibino M Kato | 5 | 5 | P Kania-Choduń K Piter | 64 | 4 | ||||||||||||||||||||||
| WC |  C Osorio R Zarazúa | 2 | 6 | [5] | 4 | L Arruabarrena E Perez | 77 | 6 | |||||||||||||||||||
| 4 | L Arruabarrena E Perez | 6 | 3 | [10] | 4 | L Arruabarrena E Perez | 1 | 6 | [10] | ||||||||||||||||||
 M Buzărnescu  A-L Friedsam | 4 | 7 | [7] | 2 | C Dolehide A Muhammad | 6 | 3 | [12] | |||||||||||||||||||
 V Kužmová AK Schmiedlová | 6 | 5 | [10] | V Kužmová AK Schmiedlová | 77 | 4 | [6] | ||||||||||||||||||||
| WC | F Contreras M Zacarías | 1 | 63 | 2 | C Dolehide A Muhammad | 62 | 6 | [10] | |||||||||||||||||||
| 2 | C Dolehide A Muhammad | 6 | 77 | ||||||||||||||||||||||||
Anastasia Pavlyuchenkova won the title, defeating Caroline Wozniacki in the final, 1–6, 6–2, 6–3.
Samantha Crawford and Madison Keys were the defending champions, having won the event in 2012, but both players chose not to defend their title. Jan Abaza and Allie Will won the title, defeating Naomi Broady and Irina Falconi in the final, 7–5, 3–6, [10–3].
Sharon Fichman and Maryna Zanevska were the defending champions, but both players chose not to participate.
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Jessica Moore and Ellen Perez were the defending champions, but chose to participate with different partners. Moore partnered alongside Monique Adamczak but lost in the first round to Viktorija Golubic and Ingrid Neel. Perez partnered alongside Arina Rodionova but lost in the first round to Naiktha Bains and Naomi Broady.
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Hsieh Su-wei and Barbora Strýcová were the defending champions, but Strýcová retired from professional tennis in May 2021. Hsieh played alongside Elise Mertens, but lost in the second round to Sharon Fichman and Giuliana Olmos.
This was the first edition of the event.
Caroline Dolehide and Maria Sanchez were the defending champions but chose not to participate.
Catherine Harrison and Sabrina Santamaria defeated Han Xinyun and Yana Sizikova in the final, 1–6, 7–5, [10–6] to win the doubles tennis title at the 2022 Monterrey Open.
Xu Yifan and Yang Zhaoxuan defeated Asia Muhammad and Ena Shibahara in the final, 7–5, 7–6(7–4) to win the women's doubles tennis title at the 2022 Indian Wells Masters. They became the first all-Chinese team to win a WTA 1000-level title.
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Shelby Rogers was the defending champion but chose not to participate.
Asia Muhammad and Taylor Townsend were the reigning champions from 2020, when the event was last held, but chose to compete in Adelaide instead.