4-Nitrobenzoic acid

Last updated
4-Nitrobenzoic acid
4-Nitrobenzoic acid.svg
Names
Preferred IUPAC name
4-Nitrobenzoic acid
Other names
p-Nitrobenzoic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.000.479 OOjs UI icon edit-ltr-progressive.svg
PubChem CID
UNII
  • InChI=1S/C7H5NO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4H,(H,9,10) Yes check.svgY
    Key: OTLNPYWUJOZPPA-UHFFFAOYSA-N Yes check.svgY
  • InChI=1/C7H5NO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4H,(H,9,10)
    Key: OTLNPYWUJOZPPA-UHFFFAOYAB
  • O=[N+]([O-])c1ccc(C(=O)O)cc1
Properties
C7H5NO4
Molar mass 167.1189 g/mol [1]
AppearanceLight yellow crystalline powder [2]
Density 1.58 [2]
Melting point 237 °C (459 °F; 510 K) [2]
Boiling point Sublimes [2]
<0.1 g/100 mL at 26 °C [3]
Acidity (pKa)3.41 (in water), [4] 9.1 (in DMSO) [5]
−78.81·10−6 cm3/mol
Related compounds
Related compounds
Benzoic acid
Nitrobenzene
Anthranilic acid
3,5-Dinitrobenzoic acid, 3-Nitrobenzoic acid, 2-Nitrobenzoic acid
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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4-Nitrobenzoic acid is an organic compound with the formula C6H4(NO2)CO2H. It is a pale yellow solid. It is a precursor to 4-nitrobenzoyl chloride, the precursor to the anesthetic procaine and folic acid. It is also a precursor to 4-aminobenzoic acid. [6]

Contents

Production

4-Nitrobenzoic acid is prepared by oxidation of 4-nitrotoluene using oxygen or dichromate as oxidants. [7]

4-Nitrobenzoesaure.svg

Alternatively, it has been prepared by nitration of polystyrene followed by oxidation of the alkyl substituent. This method proceeds with improved para/ortho selectivity owing to the steric protection of the ortho positions by the polymer backbone.

Safety

This compound has a rat LD50 of 1960 mg/kg. [8]

References

  1. "4-nitrobenzoic acid - PubChem Public Chemical Database" . Retrieved 11 April 2010.
  2. 1 2 3 4 "Safety data for p-nitrobenzoic acid". Archived from the original on 27 May 2008. Retrieved 11 April 2010.
  3. "p-Nitrobenzoic acid". Archived from the original on 7 May 2010. Retrieved 11 April 2010.
  4. "Dissociation Constants Of Organic Acids And Bases" . Retrieved 11 April 2010.
  5. "Bordwell pKa Table (Acidity in DMSO)" . Retrieved 11 April 2010.
  6. Takao Maki; Kazuo Takeda (2002). "Benzoic Acid and Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_555. ISBN   3527306730..
  7. O. Kamm; A. O. Matthews (1922). "p-Nitrobenzoic Acid". Org. Synth. 2: 53. doi:10.15227/orgsyn.002.0053.
  8. "Material Safety Data Sheet - P-nitrobenzoic acid MSDS". Archived from the original on 7 August 2011. Retrieved 11 April 2010.