ACTR1B

Last updated
ACTR1B
Identifiers
Aliases ACTR1B , ARP1B, CTRN2, PC3, ARP1 actin-related protein 1 homolog B, centractin beta, ARP1 actin related protein 1 homolog B, actin related protein 1B
External IDs OMIM: 605144 MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B
Orthologs
SpeciesHumanMouse
Entrez

10120

226977

Ensembl

ENSG00000115073

ENSMUSG00000037351

UniProt

P42025

Q8R5C5

RefSeq (mRNA)

NM_005735

NM_146107

RefSeq (protein)

NP_005726

NP_666219

Location (UCSC) Chr 2: 97.66 – 97.66 Mb Chr 1: 36.74 – 36.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene. [5] [6] [7]

Contents

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex. [7]

Related Research Articles

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(See also: List of proteins in the human body)

<span class="mw-page-title-main">ACTR2</span> Mammalian protein found in Homo sapiens

(See also: List of proteins in the human body)

<span class="mw-page-title-main">Dynactin</span>

Dynactin is a 23 subunit protein complex that acts as a co-factor for the microtubule motor cytoplasmic dynein-1. It is built around a short filament of actin related protein-1 (Arp1).

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<span class="mw-page-title-main">ACTR1A</span> Protein-coding gene in the species Homo sapiens

Alpha-centractin (yeast) or ARP1 is a protein that in humans is encoded by the ACTR1A gene.

<span class="mw-page-title-main">ACTG2</span> Protein-coding gene in the species Homo sapiens

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.

<span class="mw-page-title-main">ARPC3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">BICD2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">CHRNA5</span> Protein-coding gene in the species Homo sapiens

Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

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<span class="mw-page-title-main">ARPC1A</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">DCTN3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Troponin C, skeletal muscle</span> Protein-coding gene in the species Homo sapiens

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.

<span class="mw-page-title-main">AP4M1</span> Protein-coding gene in the species Homo sapiens

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.

<span class="mw-page-title-main">ACTR3B</span> Gene of the species Homo sapiens

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115073 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037351 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC   301159 . PMID   7696711.
  6. ↑ Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID   10343100. S2CID   83665096.
  7. 1 2 "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".

Further reading



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