AFTPH

AFTPH
Identifiers
Aliases	AFTPH , Nbla10388, aftiphilin
External IDs	MGI: 1923012 HomoloGene: 9764 GeneCards: AFTPH
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p14 Start 64,524,305 bp [1] End 64,593,005 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 A3.1 Start 20,635,084 bp [2] End 20,691,589 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla sperm cardia cerebellar vermis pylorus parotid gland nipple superior surface of tongue thoracic diaphragm trachea Top expressed in spermatocyte submandibular gland lacrimal gland dorsomedial hypothalamic nucleus habenula olfactory epithelium left colon thymus cerebellar cortex spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding Cellular component AP-1 adaptor complex cytosol Golgi apparatus intracellular membrane-bounded organelle nucleus cytoplasm trans-Golgi network membrane Biological process protein transport intracellular transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54812 216549 Ensembl ENSG00000119844 ENSMUSG00000049659 UniProt Q6ULP2 Q80WT5 RefSeq (mRNA) NM_001002243 NM_017657 NM_203437 NM_001252503 NM_001290545 NM_181411 RefSeq (protein) NP_001002243 NP_060127 NP_982261 NP_001362898 NP_001362899 NP_001362900 NP_001362901 NP_001362902 NP_001239432 NP_001277474 NP_852076 Location (UCSC) Chr 2: 64.52 – 64.59 Mb Chr 11: 20.64 – 20.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clathrin-binding box of Aftiphilin
Identifiers
Symbol	Clathrin_bdg
Pfam	PF15045
InterPro	IPR029205
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Aftiphilin is a protein that in humans is encoded by the AFTPH gene. ^{[5] [6] [7]} It forms a stable complex with p200 and synergin gamma. ^{[6] [7]} It contains a clathrin box with two known clathrin-binding sequence motifs, is involved in vesicle trafficking ^[8] and is found in many eukaryotes.

References

1. GRCh38: Ensembl release 89: ENSG00000119844 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049659 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi: 10.1074/jbc.M311873200 . PMID   14665628.
6. Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC   1087257 . PMID   15758025.
7. Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID   15811338. S2CID   23970781.
8. Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (December 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC   2592662 . PMID   18815278.

External links

• Human AFTPH genome location and AFTPH gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.