AGPAT1

Last updated

AGPAT1
Identifiers
Aliases AGPAT1 , 1-G15, LPAAT-alpha, LPAATA, 1-acylglycerol-3-phosphate O-acyltransferase 1
External IDs OMIM: 603099; MGI: 1932075; HomoloGene: 55973; GeneCards: AGPAT1; OMA:AGPAT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006411
NM_032741
NM_001371437
NM_001371438
NM_001371439

Contents

NM_001163379
NM_018862

RefSeq (protein)

NP_006402
NP_116130
NP_001358366
NP_001358367
NP_001358368

NP_001156851
NP_061350

Location (UCSC) Chr 6: 32.17 – 32.18 Mb Chr 17: 34.82 – 34.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme encoded by the AGPAT1 gene in humans. [5] [6] [7]

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). Both LPA and PA are phospholipids involved in signal transduction and in lipid biosynthesis within cells. The enzyme is localized in the endoplasmic reticulum. The gene is situated in the class III region of the human major histocompatibility complex (MHC). Alternative splicing of this gene results in two transcript variants, both of which encode the same protein. [7]

References

  1. 1 2 3 ENSG00000235758, ENSG00000228892, ENSG00000204310, ENSG00000226467, ENSG00000227642, ENSG00000206324 GRCh38: Ensembl release 89: ENSG00000236873, ENSG00000235758, ENSG00000228892, ENSG00000204310, ENSG00000226467, ENSG00000227642, ENSG00000206324 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034254 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Aguado B, Campbell RD (Mar 1998). "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex". J Biol Chem. 273 (7): 4096–105. doi: 10.1074/jbc.273.7.4096 . PMID   9461603.
  6. Stamps AC, Elmore MA, Hill ME, Kelly K, Makda AA, Finnen MJ (Sep 1997). "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases". Biochem J. 326. ( Pt 2) (2): 455–61. doi:10.1042/bj3260455. PMC   1218691 . PMID   9291118.
  7. 1 2 "Entrez Gene: AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)".

Further reading