AKAP8

AKAP8
Identifiers
Aliases	AKAP8 , AKAP 95, AKAP-8, AKAP-95, AKAP95, A-kinase anchoring protein 8
External IDs	OMIM: 604692 MGI: 1928488 HomoloGene: 4278 GeneCards: AKAP8
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.12 Start 15,353,385 bp [1] End 15,379,815 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 32,522,646 bp [2] End 32,540,212 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube Achilles tendon gastrocnemius muscle gastric mucosa left uterine tube spleen transverse colon subcutaneous adipose tissue skin of abdomen Top expressed in otic placode cerebellar cortex cumulus cell saccule superior frontal gyrus primitive streak thymus medullary collecting duct lymph node abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding zinc ion binding double-stranded DNA binding protein kinase A regulatory subunit binding histone deacetylase binding DEAD/H-box RNA helicase binding protein binding NF-kappaB binding RNA binding Cellular component Golgi apparatus female pronucleus membrane condensed chromosome nucleus mitochondrion nucleoplasm nucleolus nuclear matrix cytoplasm Biological process positive regulation of histone deacetylation mitotic chromosome condensation signal transduction cell cycle G2/M phase transition regulation of transcription, DNA-templated immune system process cellular response to lipopolysaccharide cellular response to prostaglandin E stimulus transcription, DNA-templated protein transport negative regulation of tumor necrosis factor production innate immune response mitotic cell cycle transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10270 56399 Ensembl ENSG00000105127 ENSMUSG00000024045 UniProt O43823 Q9DBR0 RefSeq (mRNA) NM_005858 NM_019774 NM_001357760 RefSeq (protein) NP_005849 NP_062748 NP_001344689 Location (UCSC) Chr 19: 15.35 – 15.38 Mb Chr 17: 32.52 – 32.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene. ^{[5] [6]}

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is redistributed to distinct locations during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA. ^[6]

Interactions

AKAP8 has been demonstrated to interact with:

• Cyclin D3 ^[7]
• DDX5, ^[8]
• MCM2, ^[9]
• MYCBP, ^[10] and
• PRKAR2A. ^{[5] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000105127 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024045 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skalhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Tasken K (Mar 1998). "Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95". Exp Cell Res. 238 (2): 305–16. doi:10.1006/excr.1997.3855. PMID   9473338.
6. "Entrez Gene: AKAP8 A kinase (PRKA) anchor protein 8".
7. Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (Mar 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC   1223988 . PMID   14641107.
8. Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM (May 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. doi: 10.1074/jbc.M101171200 . PMID   11279182.
9. Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (Jul 2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. doi: 10.1074/jbc.M300765200 . PMID   12740381.
10. Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi: 10.1074/jbc.M206387200 . PMID   12414807.
11. Collas P, Le Guellec K, Taskén K (Dec 1999). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC   2168084 . PMID   10601332.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID   9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID   11807172.
• Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC   2168084 . PMID   10601332.
• Steen RL, Cubizolles F, Le Guellec K, Collas P (2000). "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract". J. Cell Biol. 149 (3): 531–6. doi:10.1083/jcb.149.3.531. PMC   2174845 . PMID   10791967.
• Akileswaran L, Taraska JW, Sayer JA, et al. (2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. doi: 10.1074/jbc.M101171200 . PMID   11279182.
• Eide T, Carlson C, Taskén KA, et al. (2002). "Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting". EMBO Rep. 3 (5): 426–32. doi:10.1093/embo-reports/kvf089. PMC   1084102 . PMID   11964380.
• Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (2003). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. doi: 10.1074/jbc.M206387200 . PMID   12414807.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Eide T, Taskén KA, Carlson C, et al. (2003). "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication". J. Biol. Chem. 278 (29): 26750–6. doi: 10.1074/jbc.M300765200 . PMID   12740381.
• Arsenijevic T, Degraef C, Dumont JE, et al. (2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". Biochem. J. 378 (Pt 2): 673–9. doi:10.1042/BJ20031765. PMC   1223988 . PMID   14641107.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Kamada S, Kikkawa U, Tsujimoto Y, Hunter T (2005). "A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like association". Mol. Cell. Biol. 25 (21): 9469–77. doi:10.1128/MCB.25.21.9469-9477.2005. PMC   1265837 . PMID   16227597.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• AKAP8 human gene location in the UCSC Genome Browser .
• AKAP8 human gene details in the UCSC Genome Browser .